Faculty Opinions recommendation of A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi.

2008 ◽  
Author(s):  
C Graham Clark
Keyword(s):  
Encephalitozoon Cuniculi

scholarly journals In Vitro Susceptibilities of the MicrosporidiaEncephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to Albendazole and Its Sulfoxide and Sulfone Metabolites

1998 ◽  
Vol 42 (12) ◽  
pp. 3301-3303 ◽  
Author(s):  
Olivier Ridoux ◽  
Michel Drancourt
Keyword(s):  
Encephalitozoon Cuniculi ◽  
Albendazole Sulfoxide ◽  
Encephalitozoon Intestinalis ◽  
Degree Of Oxidation ◽  
Albendazole Sulfone

ABSTRACT In vitro comparisons demonstrated that the efficacy of albendazole, albendazole-sulfoxide, and albendazole-sulfone against pathogenicEncephalitozoon species was proportional to the degree of oxidation at a concentration of >10−3 μg/ml. Furthermore, at a concentration of <10−2 μg/ml, benzimidazoles were more effective against Encephalitozoon cuniculi and Encephalitozoon hellem than againstEncephalitozoon intestinalis.

Direct agglutination test for Encephalitozoon cuniculi

2006 ◽  
Vol 135 (3-4) ◽  
pp. 235-240 ◽  
Author(s):  
Carly N. Jordan ◽  
Anne M. Zajac ◽  
Karen S. Snowden ◽  
David S. Lindsay
Keyword(s):  
Agglutination Test ◽  
Direct Agglutination Test ◽  
Encephalitozoon Cuniculi

scholarly journals Mammalian Microsporidiosis

2000 ◽  
Vol 37 (2) ◽  
pp. 113-128 ◽  
Author(s):  
K. Wasson ◽  
R. L. Peper
Keyword(s):  
Animal Species ◽  
Comparative Anatomy ◽  
Polar Filament ◽  
Enterocytozoon Bieneusi ◽  
Human Infection ◽  
Opportunistic Pathogens ◽  
Encephalitozoon Cuniculi ◽  
Obligate Intracellular ◽  
Encephalitozoon Intestinalis ◽  
Potential Pathogen

The phylum Microspora contains a diverse group of single-celled, obligate intracellular protozoa sharing a unique organelle, the polar filament, and parasitizing a wide variety of invertebrate and vertebrate animals, including insects, fish, birds, and mammals. Encephalitozoon cuniculi is the classic microsporidial parasite of mammals, and encephalitozoonosis in rabbits and rodents has been and continues to be recognized as a confounding variable in animal-based biomedical research. Although contemporary research colonies are screened for infection with this parasite, E. cuniculi remains a cause of morbidity and mortality in pet and conventionally raised rabbits. In addition, E. cuniculi is a potential pathogen of immature domestic dogs and farm-raised foxes. The recent discovery and identification of Encephalitozoon intestinalis, Encephalitozoon hellem, and Enterocytozoon bieneusi, in addition to E. cuniculi, as opportunistic pathogens of humans have renewed interest in the Microspora. Veterinary pathologists, trained in the comparative anatomy of multiple animal species and infectious disease processes, are in a unique position to contribute to the diagnosis and knowledge of the pathogenesis of these parasitic diseases. This review article covers the life cycle, ultrastructure, and biology of mammalian microsporaidia and the clinical disease and lesions seen in laboratory and domestic animals, particularly as they relate to Encephalitozoon species. Human microsporidial disease and animal models of human infection are also addressed. Often thought of as rabbit pathogens of historical importance, E. cuniculi and the related mammalian microsporidia are emerging as significant opportunistic pathogens of immunocompromised individuals.

scholarly journals Disseminated Microsporidiosis Caused by Encephalitozoon cuniculi III (Dog Type) in an Italian AIDS Patient: a Retrospective Study

2002 ◽  
Vol 15 (5) ◽  
pp. 577-583 ◽  
Author(s):  
Antonella Tosoni ◽  
Manuela Nebuloni ◽  
Angelita Ferri ◽  
Sara Bonetto ◽  
Spinello Antinori ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Encephalitozoon Cuniculi

scholarly journals Infecção experimental pelo Encephalitozoon cuniculi em camundongos imunossuprimidos com dexametasona

2002 ◽  
Vol 36 (5) ◽  
pp. 621-626 ◽  
Author(s):  
Maria Anete Lallo ◽  
Maurício José dos Santos ◽  
Eduardo Fernandes Bondan
Keyword(s):  
Encephalitozoon Cuniculi

OBJETIVO: O microsporídio Encephalitozoon cuniculi tem sido reconhecido como um patógeno oportunista em indivíduos imunossuprimidos, tais como pacientes com Aids. O objetivo do trabalho foi desenvolver animais farmacologicamente imunossuprimidos como modelo da infecção natural pelo E. cuniculi. MÉTODOS: Foram usados grupos distintos de camundongos Balb-C adultos, imunossuprimidos com diferentes doses de dexametasona (Dx, 3 ou 5 mg/kg/dia por via intraperitoneal <FONT FACE=Symbol>¾</FONT> IP) e inoculados com esporos de E. cuniculi por via IP. Também foram usados grupos controle (animais inoculados, mas nãoimunossuprimidos, e animais imunossuprimidos, mas não inoculados). Os esporos de E. cuniculi foram previamente cultivados em células MDCK. Os animais foram sacrificados e submetidos à necropsia aos 7, 14, 21, 28 e 35 dias pós-inoculação. Fragmentos teciduais foram coletados e processados para análise por microscopia de luz, utilizando-se as técnicas de coloração de Gram -chromotrope e de hematoxilina-eosina. RESULTADOS: Em todos os animais imunossuprimidos e inoculados, porém especialmente naqueles que receberam 5 mg/kg/dia de Dx, os achados de necropsia mais proeminentes foram hepato e esplenomegalia. A inoculação experimental resultou em uma infecção disseminada e não-letal, caracterizada por lesões granulomatosas em diversos órgãos (fígado, pulmões, rins, intestino, encéfalo), porém mais notadamente no tecido hepático. Esporos de E. cuniculi foram observados em poucos animais tratados com 5 mg/kg/dia de Dx aos 35 dias pós-infecção. CONCLUSÕES: Microsporidiose em camundongos imunossuprimidos com Dx fornece um modelo útil para estudos da infecção por microsporídios, assemelhando-se àquela naturalmente observada em indivíduos imunodeficientes com Aids.

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