Faculty Opinions recommendation of Long-term darifenacin treatment for overactive bladder in patients aged 65 years and older: analysis of results from a 2-year, open-label extension study.

2007 ◽  
Author(s):  
Rodolfo Testa
Keyword(s):  
Overactive Bladder ◽  
Extension Study ◽  
Open Label ◽  
Open Label Extension ◽  
Analysis Of Results

Long-term darifenacin treatment for overactive bladder in patients aged 65 years and older: analysis of results from a 2-year, open-label extension study

2007 ◽  
Vol 23 (11) ◽  
pp. 2697-2704 ◽  
Author(s):  
Simon Hill ◽  
Mostafa Elhilali ◽  
Richard J Millard ◽  
Peter L Dwyer ◽  
Karine Lheritier ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Extension Study ◽  
Open Label ◽  
Open Label Extension ◽  
Analysis Of Results

Long-term treatment with darifenacin for overactive bladder: results of a 2-year, open-label extension study

2006 ◽  
Vol 98 (5) ◽  
pp. 1025-1032 ◽  
Author(s):  
François Haab ◽  
Jacques Corcos ◽  
Paul Siami ◽  
Karin Glavind ◽  
Peter Dwyer ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Term Treatment ◽  
Extension Study ◽  
Open Label ◽  
Long Term Treatment ◽  
Open Label Extension

Sustained response and long-term safety of eculizumab in paroxysmal nocturnal hemoglobinuria

Blood ◽  
2005 ◽  
Vol 106 (7) ◽  
pp. 2559-2565 ◽  
Author(s):  
Anita Hill ◽  
Peter Hillmen ◽  
Stephen J. Richards ◽  
Dupe Elebute ◽  
Judith C. Marsh ◽  
...  
Keyword(s):  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Extension Study ◽  
Transfusion Rate ◽  
Complement Protein ◽  
Open Label ◽  
Hematologic Disorder ◽  
Humanized Monoclonal Antibody ◽  
Close Relationship ◽  
Open Label Extension

AbstractParoxysmal nocturnal hemoglobinuria (PNH) is a hematologic disorder characterized by clonal expansion of red blood cells (RBCs) lacking the ability to inhibit complement-mediated hemolysis. Eculizumab, a humanized monoclonal antibody that binds the C5 complement protein, blocks serum hemolytic activity. This study evaluated the long-term safety and efficacy of eculizumab in 11 patients with PNH during an open-label extension trial. After completion of an initial 12-week study, all patients chose to participate in the 52-week extension study. Eculizumab, administered at 900 mg every 12 to 14 days, was sufficient to completely and consistently block complement activity in all patients. A dramatic reduction in hemolysis was maintained throughout the study, with a decrease in lactate dehydrogenase (LDH) levels from 3110.7 IU/L before treatment to 622.4 IU/L (P = .002). The proportion of PNH type III RBCs increased from 36.7% at baseline to 58.4% (P = .005). The paroxysm rate of days with gross evidence of hemoglobinuria per patient each month decreased from 3.0 during screening to 0.2 (P < .001) during treatment. The median transfusion rate decreased from 1.8 U per patient each month before eculizumab treatment to 0.3 U per patient each month (P = .001) during treatment. Statistically significant improvements in quality-of-life measures were also maintained during the extension study. Eculizumab continued to be safe and well tolerated, and all patients completed the study. The close relationship between sustained terminal complement inhibition, hemolysis, and symptoms was demonstrated. (Blood. 2005; 106:2559-2565)

scholarly journals Long-term efficacy and safety of once-monthly Risperidone ISM® in the treatment of schizophrenia: Results from a 12-month open-label extension study

2022 ◽  
Vol 239 ◽  
pp. 83-91
Author(s):  
Yuriy Filts ◽  
Robert E. Litman ◽  
Javier Martínez ◽  
Lourdes Anta ◽  
Dieter Naber ◽  
...  
Keyword(s):  
Extension Study ◽  
Efficacy And Safety ◽  
Open Label ◽  
Term Efficacy ◽  
Open Label Extension

Long-Term Effectiveness and Safety of Vedolizumab in Patients with Ulcerative Colitis: 5-Year Cumulative Exposure of Gemini 1 Completers Rolling into the Gemini Open-Label Extension Study

2017 ◽  
Vol 152 (5) ◽  
pp. S602 ◽  
Author(s):  
Edward V. Loftus ◽  
Jean Frederic Colombel ◽  
Brian G. Feagan ◽  
Severine Vermeire ◽  
William J. Sandborn ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cumulative Exposure ◽  
Extension Study ◽  
Open Label ◽  
Open Label Extension
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