Faculty Opinions recommendation of Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons.

2006 ◽  
Author(s):  
Johannes Hell
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Mrna Abundance ◽  
Receptor Mrna

scholarly journals Activity Bidirectionally Regulates AMPA Receptor mRNA Abundance in Dendrites of Hippocampal Neurons

2006 ◽  
Vol 26 (32) ◽  
pp. 8339-8351 ◽  
Author(s):  
S. Y. Grooms ◽  
K.-M. Noh ◽  
R. Regis ◽  
G. J. Bassell ◽  
M. K. Bryan ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Mrna Abundance ◽  
Receptor Mrna

scholarly journals Neuropeptide Y suppresses epileptiform discharges by regulating AMPA receptor GluR2 subunit in rat hippocampal neurons

2017 ◽  
Vol 16 (1) ◽  
pp. 387-395 ◽  
Author(s):  
Wei Bu ◽  
Wen-Qing Zhao ◽  
Wen-Ling Li ◽  
Chang-Zheng Dong ◽  
Zhe Zhang ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Epileptiform Discharges

Gadolinium Reduces AMPA Receptor Desensitization and Deactivation in Hippocampal Neurons

2001 ◽  
Vol 86 (1) ◽  
pp. 173-182 ◽  
Author(s):  
Saobo Lei ◽  
John F. MacDonald
Keyword(s):  
Steady State ◽  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Time Course ◽  
Single Channel ◽  
Trivalent Cation ◽  
Receptor Desensitization ◽  
Whole Cell ◽  
Low Concentrations ◽  
Cultured Hippocampal Neurons

The actions of the trivalent cation Gd3+ on whole cell AMPA receptor-mediated currents were studied in isolated hippocampal neurons, in nucleated or outside-out patches taken from cultured hippocampal neurons, and on miniature excitatory postsynaptic currents (mEPSCs) recorded in cultured hippocampal neurons. Glutamate, AMPA, or kainate was employed to activate AMPA receptors. Applications of relatively low concentrations of Gd3+ (0.1–10 μM) substantially enhanced steady-state whole cell glutamate and kainate-evoked currents without altering peak currents, suggesting that desensitization was reduced. However, higher concentrations (>30 μM) depressed steady-state currents, indicating an underlying inhibition of channel activity. Lower concentrations of Gd3+also increased the potency of peak glutamate-evoked currents without altering that of steady-state currents. An ultrafast perfusion system and nucleated patches were then used to better resolve peak glutamate-evoked currents. Low concentrations of Gd3+ reduced peak currents, enhanced steady-state currents, and slowed the onset of desensitization, providing further evidence that this cation reduces desensitization. In the presence of cyclothiazide, a compound that blocks desensitization, a low concentration Gd3+ inhibited both peak and steady-state currents, indicating that Gd3+ both reduces desensitization and inhibits these currents. Gd3+ reduced the probability of channel opening at the peak of the currents but did not alter the single channel conductance calculated using nonstationary variance analysis. Recovery from desensitization was enhanced, and glutamate-evoked current activation and deactivation were slowed by Gd3+. The Gd3+-induced reduction in desensitization did not require the presence of the GluR2 subunit as this effect was seen in hippocampal neurons from GluR2 null-mutant mice. Gd3+ reduced the time course of decay of mEPSCs perhaps as a consequence of its slowing of AMPA receptor deactivation although an increase in the frequency of mEPSCs also suggested enhanced presynaptic release of transmitter. These results demonstrate that Gd3+ potently reduces AMPA receptor desensitization and mimics a number of the properties of the positive modulators of AMPA receptor desensitization such as cyclothiazide.

scholarly journals Introduction of Enteral Food Increases Plasma GLP-2 and Decreases GLP-2 Receptor mRNA Abundance during Pig Development

2003 ◽  
Vol 133 (6) ◽  
pp. 1781-1786 ◽  
Author(s):  
Yvette M. Petersen ◽  
Bolette Hartmann ◽  
Jens J. Holst ◽  
Isabelle Le Huerou-Luron ◽  
Charlotte R. Bjørnvad ◽  
...  
Keyword(s):  
Mrna Abundance ◽  
Receptor Mrna

Positive Allosteric Modulators of AMPA Receptors Reduce Proton-Induced Receptor Desensitization in Rat Hippocampal Neurons

2001 ◽  
Vol 85 (5) ◽  
pp. 2030-2038 ◽  
Author(s):  
Saobo Lei ◽  
Beverley A. Orser ◽  
Gregory R. L. Thatcher ◽  
James N. Reynolds ◽  
John F. MacDonald
Keyword(s):  
Ampa Receptor ◽  
Ampa Receptors ◽  
Hippocampal Neurons ◽  
Organic Nitrate ◽  
Receptor Desensitization ◽  
Open Probability ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 ◽  
Rate Of Recovery ◽  
Kinetics Of

Whole-cell or outside-out patch recordings were used to investigate the effects of protons and positive modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors on the desensitization of glutamate-evoked AMPA receptor currents in isolated hippocampal CA1 neurons. Protons inhibited glutamate-evoked currents (IC50 of 6.2 pH units) but also enhanced the apparent rate and extent of AMPA receptor desensitization. The proton-induced enhancement of desensitization could not be attributed to a reduction in the rate of recovery from desensitization or to a change in the kinetics of deactivation. Non-stationary variance analysis indicated that protons reduced maximum open probability without changing the conductance of AMPA channels. The positive modulators of AMPA receptor desensitization, cyclothiazide and GT-21-005 (an organic nitrate), reduced the proton sensitivity of AMPA receptor desensitization, which suggests that they interact with protons to diminish desensitization. In contrast, the effects of wheat germ agglutinin and aniracetam on AMPA receptor desensitization were independent of pH. These results demonstrate that a reduction in the proton sensitivity of receptor desensitization contributes to the mechanism of action of some positive modulators of AMPA receptors.

Regulation of AMPA Receptor Recruitment by the Actin Binding Protein Drebrin in Cultured Hippocampal Neurons

2012 ◽  
Vol 1 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Kenichi Kato ◽  
Tomoaki Shirao ◽  
Hiroyuki Yamazaki ◽  
Kazuyuki Imamura ◽  
Yuko Sekino
Keyword(s):  
Ampa Receptor ◽  
Hippocampal Neurons ◽  
Binding Protein ◽  
Actin Binding ◽  
Actin Binding Protein ◽  
Cultured Hippocampal Neurons

Oxytocin effects on ampa receptor mRNA regulation in hippocampus

1996 ◽  
Vol 39 (7) ◽  
pp. 593-594
Author(s):  
M. Karm-Hage ◽  
I. Liberzon ◽  
K.A. Bovenkerk ◽  
E.A. Young ◽  
J.H. Meador-Woodruff
Keyword(s):  
Ampa Receptor ◽  
Mrna Regulation ◽  
Receptor Mrna
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