Faculty Opinions recommendation of Extreme population differences across Neuregulin 1 gene, with implications for association studies.

2005 ◽  
Author(s):  
Victor Reus
Keyword(s):  
Association Studies ◽  
Population Differences ◽  
Neuregulin 1

scholarly journals Extreme population differences across Neuregulin 1 gene, with implications for association studies

2005 ◽  
Vol 11 (1) ◽  
pp. 66-75 ◽  
Author(s):  
M Gardner ◽  
A González-Neira ◽  
O Lao ◽  
F Calafell ◽  
J Bertranpetit ◽  
...  
Keyword(s):  
Association Studies ◽  
Population Differences ◽  
Neuregulin 1

scholarly journals True causal effect size heterogeneity is not required to explain trans-ethnic differences in GWAS signals

2016 ◽  
Author(s):  
Daniela Zanetti ◽  
Michael E. Weale
Keyword(s):  
Ethnic Differences ◽  
Effect Size ◽  
Complex Traits ◽  
Causal Effect ◽  
Association Studies ◽  
African Ancestry ◽  
Causal Variant ◽  
Genome Wide Association Studies ◽  
Population Differences ◽  
Relative Risks

AbstractThrough genome-wide association studies (GWASs), researchers have identified hundreds of genetic variants associated with particular complex traits. Previous studies have compared the pattern of association signals across different populations in real data, and these have detected differences in the strength and sometimes even the direction of GWAS signals. These differences could be due to a combination of (1) lack of power (insufficient sample sizes); (2) minor allele frequency (MAF) differences (again affecting power); (3) linkage disequilibrium (LD) differences (affecting power to ‘tag’ the causal variant); and (4) true differences in causal variant effect sizes (defined by relative risks).In the present work, we sought to assess whether the first three of these reasons are sufficient on their own to explain the observed incidence of trans-ethnic differences in replications of GWAS signals, or whether the fourth reason is also required. We simulated case-control data of European, Asian and African ancestry, drawing on observed MAF and LD patterns seen in the 1000-Genomes reference dataset and assuming the true causal relative risks were the same in all three populations.We found that a combination of Euro-centric SNP selection and between-population differences in LD, accentuated by the lower SNP density typical of older GWAS panels, was sufficient to explain the rate of trans-ethnic differences previously reported, without the need to assume between-population differences in true causal SNP effect size. This suggests a cross-population consistency that has implications for our understanding of the interplay between genetics and environment in the aetiology of complex human diseases.

Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia

2004 ◽  
Vol 366 (2) ◽  
pp. 158-161 ◽  
Author(s):  
Chen-Jee Hong ◽  
Sheue-Jane Huo ◽  
Ding-Lieh Liao ◽  
Kuenlin Lee ◽  
Jia-Yan Wu ◽  
...  
Keyword(s):  
Association Studies ◽  
Case Control ◽  
Neuregulin 1 ◽  
Family Based

Direct evidence for activation of the neuregulin-1/ErbB system in myocardium of dogs with pacing-induced heart failure

2008 ◽  
Vol 7 ◽  
pp. 108-108
Author(s):  
K DOGGEN ◽  
L RAY ◽  
M MATHIEU ◽  
K MCENTEE ◽  
K LEMMENS ◽  
...  
Keyword(s):  
Heart Failure ◽  
Direct Evidence ◽  
Neuregulin 1

Serotonergic Genes and Suicidality

Crisis ◽  
2001 ◽  
Vol 22 (2) ◽  
pp. 54-60 ◽  
Author(s):  
Lisheng Du ◽  
Gabor Faludi ◽  
Miklos Palkovits ◽  
David Bakish ◽  
Pavel D. Hrdina
Keyword(s):  
Suicidal Ideation ◽  
Suicidal Behavior ◽  
Tryptophan Hydroxylase ◽  
Association Studies ◽  
Receptor Gene ◽  
Brain Regions ◽  
Depressive Illness ◽  
Control Group ◽  
Serotonergic Activity ◽  
Completed Suicide

Summary: Several lines of evidence indicate that abnormalities in the functioning of the central serotonergic system are involved in the pathogenesis of depressive illness and suicidal behavior. Studies have shown that the number of brain and platelet serotonin transporter binding sites are reduced in patients with depression and in suicide victims, and that the density of 5-HT2A receptors is increased in brain regions of depressed in suicide victims and in platelets of depressed suicidal patients. Genes that code for proteins, such as tryptophan hydroxylase, 5-HT transporter, and 5-HT2A receptor, involved in regulating serotonergic neurotransmission, have thus been major candidate genes for association studies of suicide and suicidal behavior. Recent studies by our group and by others have shown that genetic variations in the serotonin-system-related genes might be associated with suicidal ideation and completed suicide. We have shown that the 102 C allele in 5-HT2A receptor gene was significantly associated with suicidal ideation (χ2 = 8.5, p < .005) in depressed patients. Patients with a 102 C/C genotype had a significantly higher mean HAMD item #3 score (indication of suicidal ideation) than T/C or T/T genotype patients. Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression and not with depression itself. We also found that the 5-HT transporter gene S/L polymorphism was significantly associated with completed suicide. The frequency of the L/L genotype in depressed suicide victims was almost double of that found in control group (48.6% vs. 26.2%). The odds ratio for the L allele was 2.1 (95% CI 1.2-3.7). The association between polymorphism in serotonergic genes and suicidality supports the hypothesis that genetic factors can modulate suicide risk by influencing serotonergic activity.

Myocardial Expression of Neuregulin-1 and Its Receptor ErbB4 in Patients with Chronic Heart Failure

2016 ◽  
Vol 64 (S 01) ◽  
Author(s):  
A. Beiras-Fernandez ◽  
J. Rothkopf ◽  
S. Kreth ◽  
A. Kornberger ◽  
U. Stock ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Neuregulin 1
Sign in / Sign up

Export Citation Format

Share Document