Faculty Opinions recommendation of RAS is regulated by the let-7 microRNA family.

2005 ◽  
Author(s):  
Ilaria Rebay
Keyword(s):  
Microrna Family

scholarly journals Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0200602 ◽  
Author(s):  
Katja Derkow ◽  
Rosa Rössling ◽  
Carola Schipke ◽  
Christina Krüger ◽  
Jakob Bauer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Microrna Family

scholarly journals The Molecular Basis and Therapeutic Potential of Let-7 MicroRNAs against Colorectal Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Rei Mizuno ◽  
Kenji Kawada ◽  
Yoshiharu Sakai
Keyword(s):  
Colorectal Cancer ◽  
Molecular Basis ◽  
Posttranscriptional Regulation ◽  
Therapeutic Agent ◽  
Therapeutic Potential ◽  
Noncoding Rnas ◽  
Intestinal Tumorigenesis ◽  
C Elegans ◽  
Microrna Family ◽  
Underlying Mechanisms

Although a number of studies have revealed the underlying mechanisms which regulate the development of colorectal cancer (CRC), we have not completely overcome this disease yet. Accumulating evidence has shown that the posttranscriptional regulation by the noncoding RNAs such as microRNAs plays an important role in the development or progression of CRC. Among a number of microRNAs, the let-7 microRNA family that was first discovered in C. elegans and conserved from worms to humans has been linked with the development of many types of cancers including CRC. The expression level of let-7 microRNAs is temporally low during the normal developmental processes, while elevated in the differentiated tissues. The let-7 microRNAs regulate the cell proliferation, cell cycle, apoptosis, metabolism, and stemness. In CRC, expressions of let-7 microRNAs have been reported to be reduced, and so let-7 microRNAs are considered to be a tumor suppressor. In this review, we discuss the mechanisms regulating the let-7 microRNA expression and the downstream targets of let-7 in the context of intestinal tumorigenesis. The application of let-7 mimics is also highlighted as a novel therapeutic agent.

scholarly journals miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro

2019 ◽  
Author(s):  
Roza K. Przanowska ◽  
Ewelina Sobierajska ◽  
Zhangli Su ◽  
Kate Jensen ◽  
Piotr Przanowski ◽  
...  
Keyword(s):  
Muscle Function ◽  
Skeletal Muscle Regeneration ◽  
C2c12 Myoblasts ◽  
Skeletal Myoblasts ◽  
Microrna Targets ◽  
Microrna Family ◽  
Differentiation Pathways

AbstractmiR-206, miR-1a-1 and miR-1a-2 are induced during differentiation of skeletal myoblasts and promote myogenesis in vitro. miR-206 is required for skeletal muscle regeneration in vivo. Although this microRNA family is hypothesized to play an essential role in differentiation, a triple knockout of the three genes has not been done to test this hypothesis. We report that triple KO C2C12 myoblasts generated using CRISPR/Cas9 method differentiate despite the expected de-repression of the microRNA targets. Surprisingly, their mitochondrial function is diminished. Triple KO mice demonstrate partial embryonic lethality, most likely due to the role of miR-1a in cardiac muscle differentiation. Two triple KO mice survive and grow normally to adulthood with smaller myofiber diameter and diminished physical performance. Thus, unlike other microRNAs important in other differentiation pathways, the miR-206 family is not absolutely essential for myogenesis and is instead a modulator of optimal differentiation of skeletal myoblasts.

scholarly journals The miR-30 MicroRNA Family Targets smoothened to Regulate Hedgehog Signalling in Zebrafish Early Muscle Development

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65170 ◽  
Author(s):  
Ami Ketley ◽  
Anne Warren ◽  
Emily Holmes ◽  
Martin Gering ◽  
A. Aziz Aboobaker ◽  
...  
Keyword(s):  
Muscle Development ◽  
Hedgehog Signalling ◽  
Microrna Family

The Role of miR-154 microRNA Family in IPF.

2009 ◽  
Author(s):  
J Milosevic ◽  
KV Pandit ◽  
R Jacobs ◽  
PV Benos ◽  
Z Yakhini ◽  
...  
Keyword(s):  
Microrna Family

scholarly journals Expression profiling across wild and cultivated tomatoes supports the relevance of early miR482/2118 suppression for Phytophthora resistance

2018 ◽  
Vol 285 (1873) ◽  
pp. 20172560 ◽  
Author(s):  
Sophie de Vries ◽  
Andreas Kukuk ◽  
Janina K. von Dahlen ◽  
Anika Schnake ◽  
Thorsten Kloesges ◽  
...  
Keyword(s):  
Expression Profiling ◽  
Rna Silencing ◽  
Pathogen Resistance ◽  
Tomato Species ◽  
Major Class ◽  
Microrna Family ◽  
Specific Pathogen ◽  
Phytophthora Resistance ◽  
Silencing Suppression ◽  
Leucine Rich Repeats

Plants possess a battery of specific pathogen resistance ( R- )genes. Precise R- gene regulation is important in the presence and absence of a pathogen. Recently, a microRNA family, miR482/2118, was shown to regulate the expression of a major class of R- genes , nucleotide-binding site leucine-rich repeats ( NBS-LRRs ). Furthermore, RNA silencing suppressor proteins, secreted by pathogens, prevent the accumulation of miR482/2118, leading to an upregulation of R- genes. Despite this transcriptional release of R -genes, RNA silencing suppressors positively contribute to the virulence of some pathogens . To investigate this paradox, we analysed how the regulation of NBS-LRRs by miR482/2118 has been shaped by the coevolution between Phytophthora infestans and cultivated and wild tomatoes. We used degradome analyses and qRT-PCR to evaluate and quantify the co-expression of miR482/2118 and their NBS-LRR targets. Our data show that miR482/2118-mediated targeting contributes to the regulation of NBS-LRRs in Solanum lycopersicum. Based on miR482/2118 expression profiling in two additional tomato species—with different coevolutionary histories with P. infestans —we hypothesize that pathogen-mediated RNA silencing suppression is most effective in the interaction between S. lycopersicum and P. infestans . Furthermore, an upregulation of miR482/2118 early in the infection may increase susceptibility to P. infestans .

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