Faculty Opinions recommendation of High density lipoproteins facilitate hepatitis C virus entry through the scavenger receptor class B type I.

2005 ◽  
Author(s):  
Jens Bukh
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Scavenger Receptor ◽  
High Density ◽  
High Density Lipoproteins ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B

scholarly journals High Density Lipoproteins Facilitate Hepatitis C Virus Entry through the Scavenger Receptor Class B Type I

2005 ◽  
Vol 280 (9) ◽  
pp. 7793-7799 ◽  
Author(s):  
Cécile Voisset ◽  
Nathalie Callens ◽  
Emmanuelle Blanchard ◽  
Anne Op De Beeck ◽  
Jean Dubuisson ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Scavenger Receptor ◽  
High Density ◽  
High Density Lipoproteins ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B

scholarly journals Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular Determinants

2009 ◽  
Vol 84 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Maria Teresa Catanese ◽  
Helenia Ansuini ◽  
Rita Graziani ◽  
Thierry Huby ◽  
Martine Moreau ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Entry ◽  
Scavenger Receptor ◽  
Specific Protein ◽  
Early Event ◽  
Type I ◽  
Direct Role ◽  
Scavenger Receptor Class ◽  
Class B

ABSTRACT Scavenger receptor class B type I (SR-BI) is an essential receptor for hepatitis C virus (HCV) and a cell surface high-density-lipoprotein (HDL) receptor. The mechanism of SR-BI-mediated HCV entry, however, is not clearly understood, and the specific protein determinants required for the recognition of the virus envelope are not known. HCV infection is strictly linked to lipoprotein metabolism, and HCV virions may initially interact with SR-BI through associated lipoproteins before subsequent direct interactions of the viral glycoproteins with SR-BI occur. The kinetics of inhibition of cell culture-derived HCV (HCVcc) infection with an anti-SR-BI monoclonal antibody imply that the recognition of SR-BI by HCV is an early event of the infection process. Swapping and single-substitution mutants between mouse and human SR-BI sequences showed reduced binding to the recombinant soluble E2 (sE2) envelope glycoprotein, thus suggesting that the SR-BI interaction with the HCV envelope is likely to involve species-specific protein elements. Most importantly, SR-BI mutants defective for sE2 binding, although retaining wild-type activity for receptor oligomerization and binding to the physiological ligand HDL, were impaired in their ability to fully restore HCVcc infectivity when transduced into an SR-BI-knocked-down Huh-7.5 cell line. These findings suggest a specific and direct role for the identified residues in binding HCV and mediating virus entry. Moreover, the observation that different regions of SR-BI are involved in HCV and HDL binding supports the hypothesis that new therapeutic strategies aimed at interfering with virus/SR-BI recognition are feasible.

Scavenger Receptor Class B Type I Mediates Cell Entry of Hepatitis C Virus

2008 ◽  
Vol 36 (6) ◽  
pp. 1319-1325 ◽  
Author(s):  
ZS Jia ◽  
DW Du ◽  
YF Lei ◽  
X Wei ◽  
W Yin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cho Cells ◽  
Hepg2 Cells ◽  
Scavenger Receptor ◽  
Chinese Hamster ◽  
Hcv Infection ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B

This study assessed the functional role of human scavenger receptor class B type I (SR-BI) as a putative hepatitis C virus (HCV) receptor using Chinese hamster ovary (CHO) cells transfected with human SR-BI (CHO–huSR-BI). The expression of SR-BI by primary Tupaia hepatocytes (PTHs), human hepatocarcinoma cell line (HepG2) cells, untransfected CHO cells and CHO–huSR-BI cells was analysed by Western blotting. Receptor competition assays showed that anti-SR-BI antibodies that block the binding of soluble envelope glycoprotein E2 could prevent HCV infection. Pre-incubation of CHO–huSR-BI and HepG2 cells with anti-SR-BI antibodies resulted in marked inhibition of E2 binding. After incubation with HCV RNA-positive serum from a patient with chronic HCV infection, however, HCV infection could not be detected in CHO–huSR-BI cells, but was detected in PTHs. These results demonstrate that, whilst SR-BI represents an important cell surface molecule for HCV infection, the presence of SR-BI alone is insufficient for HCV entry.

Induction of Krüppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I

FEBS Journal ◽  
2010 ◽  
Vol 277 (18) ◽  
pp. 3780-3788 ◽  
Author(s):  
Tao Yang ◽  
Caihong Chen ◽  
Bin Zhang ◽  
He Huang ◽  
Ganqiu Wu ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
High Density ◽  
High Density Lipoproteins ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B

scholarly journals The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination

Hepatology ◽  
2012 ◽  
Vol 57 (2) ◽  
pp. 492-504 ◽  
Author(s):  
Muhammad N. Zahid ◽  
Marine Turek ◽  
Fei Xiao ◽  
Viet Loan Dao Thi ◽  
Maryse Guérin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Scavenger Receptor ◽  
Type I ◽  
Hepatitis C Virus Infection ◽  
Viral Dissemination ◽  
Scavenger Receptor Class ◽  
Class B

scholarly journals The Scavenger Receptor Class B, Type I Is a Primary Determinant of Paraoxonase-1 Association With High-Density Lipoproteins

2010 ◽  
Vol 30 (11) ◽  
pp. 2121-2127 ◽  
Author(s):  
Richard W. James ◽  
Marie-Claude Brulhart-Meynet ◽  
Anurag Kumar Singh ◽  
Brigitte Riederer ◽  
Ursula Seidler ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
High Density ◽  
Paraoxonase 1 ◽  
High Density Lipoproteins ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Primary Determinant

scholarly journals Erratum. High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes 2016;65:3091–3103

Diabetes ◽  
2017 ◽  
Vol 66 (4) ◽  
pp. 1097.2-1097
Author(s):  
Joanne T.M. Tan ◽  
Hamish C.G. Prosser ◽  
Louise L. Dunn ◽  
Laura Z. Vanags ◽  
Anisyah Ridiandries ◽  
...  
Keyword(s):  
Type I Diabetes ◽  
Scavenger Receptor ◽  
High Density ◽  
High Density Lipoproteins ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Impaired Angiogenesis

Scavenger Receptor Class B Type I is a Hepatitis C Virus Receptor on Human Dendritic Cells

2006 ◽  
Vol 44 (01) ◽  
Author(s):  
H Barth ◽  
EK Schnober ◽  
C Neumann-Haefelin ◽  
R Thimme ◽  
HE Blum ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Scavenger Receptor ◽  
Type I ◽  
Virus Receptor ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Human Dendritic Cells
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