Faculty Opinions recommendation of Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.

2005 ◽  
Author(s):  
Karl-Peter Giese
Keyword(s):  
Pyramidal Neurons ◽  
Long Term Potentiation ◽  
Intrinsic Excitability ◽  
Ca1 Pyramidal Neurons ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Activity Dependent

scholarly journals Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Qian Yang ◽  
Geng Zhu ◽  
Dandan Liu ◽  
Jue-Gang Ju ◽  
Zhen-Hua Liao ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Pyramidal Neurons ◽  
Long Term Potentiation ◽  
Ca1 Pyramidal Neurons ◽  
Term Potentiation ◽  
Hippocampal Ca1

The involvement of nonspiking cells in long-term potentiation of synaptic transmission in the hippocampus

1988 ◽  
Vol 66 (6) ◽  
pp. 841-844 ◽  
Author(s):  
B. R. Sastry ◽  
J. W. Goh ◽  
P. B. Y. May ◽  
S. S. Chirwa
Keyword(s):  
Pyramidal Neurons ◽  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Stratum Radiatum ◽  
Ca1 Pyramidal Neurons ◽  
Term Potentiation ◽  
Ca1 Area ◽  
Glial Depolarization ◽  
Stimulation Of

In guinea pig hippocampal slices, stimulation of stratum radiatum during depolarization (with intracellular current injections) of nonspiking cells (presumed to be glia) in the apical dendritic area of CA1 pyramidal neurons resulted in a subsequent long-term potentiation of intracellularly recorded excitatory postsynaptic potentials as well as extracellularly recorded population spikes in the CA1 area. Tetanic stimulation of stratum radiatum resulted in a subsequent prolonged depolarization of the presumed glial cells, and this depolarization was smaller when the tetanus was given during the presence of 2-amino-5-phosphonovalerate or when the slices were exposed to Ca2+-free medium containing Mn2+ and Mg2+. These results suggest that glial depolarization is involved as one of the steps in generating long-term potentiation.

scholarly journals Persistent Synaptic Activity Produces Long-Lasting Enhancement of Endocannabinoid Modulation and Alters Long-Term Synaptic Plasticity

2007 ◽  
Vol 97 (6) ◽  
pp. 4386-4389 ◽  
Author(s):  
Ping Jun Zhu ◽  
David M. Lovinger
Keyword(s):  
Low Frequency ◽  
Long Term Potentiation ◽  
Information Storage ◽  
Synaptic Activity ◽  
Inhibitory Synapses ◽  
Term Potentiation ◽  
Hippocampal Ca1 ◽  
Gabaergic Synapses ◽  
Activity Dependent

Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we show that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatergic synapses. These endocannabinoid-mediated plastic changes could contribute to information storage within the brain.

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