Faculty Opinions recommendation of RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.

2003 ◽  
Author(s):  
Robert Parton
Keyword(s):  
Tyrosine Kinase ◽  
Src Tyrosine Kinase

scholarly journals Evidence for two distinct 60-kilodalton substrates of the SRC tyrosine kinase.

1994 ◽  
Vol 269 (47) ◽  
pp. 29602-29608
Author(s):  
W Ogawa ◽  
Y Hosomi ◽  
K Shii ◽  
R A Roth
Keyword(s):  
Tyrosine Kinase ◽  
Src Tyrosine Kinase

scholarly journals Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik

2012 ◽  
Vol 19 (9) ◽  
pp. 1459-1469 ◽  
Author(s):  
J Lopez ◽  
C Hesling ◽  
J Prudent ◽  
N Popgeorgiev ◽  
R Gadet ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Src Tyrosine Kinase

Src tyrosine kinase promotes survival and resistance to chemotherapeutics in a mouse ovarian cancer cell line

2003 ◽  
Vol 309 (2) ◽  
pp. 377-383 ◽  
Author(s):  
Yolande Pengetnze ◽  
Mary Steed ◽  
Katherine F. Roby ◽  
Paul F. Terranova ◽  
Christopher C. Taylor
Keyword(s):  
Ovarian Cancer ◽  
Tyrosine Kinase ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Src Tyrosine Kinase

Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model

BioFactors ◽  
2018 ◽  
Vol 45 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Burak Oz ◽  
Ahmet Yildirim ◽  
Servet Yolbas ◽  
Zulfinaz Betul Celik ◽  
Ebru Onalan Etem ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Collagen Induced Arthritis ◽  
Src Tyrosine Kinase ◽  
Arthritis Model

Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway

2002 ◽  
Vol 283 (4) ◽  
pp. G893-G899 ◽  
Author(s):  
Monica C. Chen ◽  
Travis E. Solomon ◽  
Eduardo Perez Salazar ◽  
Robert Kui ◽  
Enrique Rozengurt ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Epithelial Cells ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Tyrosine Phosphorylation ◽  
Molecular Mechanisms ◽  
Kinase Inhibitor ◽  
Paracellular Permeability ◽  
Maximal Response ◽  
Src Tyrosine Kinase

Previous studies found that epidermal growth factor (EGF) decreased paracellular permeability in gastric mucosa, but the other physiological regulators and the molecular mechanisms mediating these responses remain undefined. We investigated the role of secretin and Src in regulating paracellular permeability because secretin regulates gastric chief cell function and Src mediates events involving the cytoskeletal-membrane interface, respectively. Confluent monolayers were formed from canine gastric epithelial cells in short-term culture on Transwell filter inserts. Resistance was monitored in the presence of secretin with or without specific kinase inhibitors. Tyrosine phosphorylation of Src at Tyr416 was measured with a site-specific phosphotyrosine antibody. Basolateral, but not apical, secretin at concentrations from 1 to 100 nM dose dependently increased resistance; this response was rapid and sustained over hours. PP2 (10 μM), a selective Src tyrosine kinase inhibitor, but not the inactive isomer PP3, abolished the increase in resistance by secretin but only modestly attenuated apical EGF effects. AG-1478 (100 nM), a specific EGF receptor tyrosine kinase inhibitor, attenuated the resistance increase to EGF but not secretin. Secretin, but not EGF, induced tyrosine phosphorylation of Src at Tyr416 in a dose-dependent fashion, with the maximal response observed at 1 min. PP2, but not PP3, dramatically inhibited this tyrosine phosphorylation. Secretin increases paracellular resistance in gastric mucosa through a Src-mediated pathway, while the effect of EGF is Src independent. Src appears to mediate the physiological effects of this Gs-coupled receptor in primary epithelial cells.

scholarly journals Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling

2006 ◽  
Vol 25 (14) ◽  
pp. 3335-3346 ◽  
Author(s):  
Ingvild Bjellmo Johnsen ◽  
Thuy Thanh Nguyen ◽  
Monika Ringdal ◽  
Anne Merete Tryggestad ◽  
Oddmund Bakke ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Toll Like Receptor ◽  
Antiviral Signaling ◽  
Src Tyrosine Kinase
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