Faculty Opinions recommendation of Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development.

2001 ◽  
Author(s):  
Patrick Tam
Keyword(s):  
Normal Mouse ◽  
Mouse Development ◽  
Cleavage Division

Expression and Localization of Bestrophin during Normal Mouse Development

2003 ◽  
Vol 44 (8) ◽  
pp. 3622 ◽  
Author(s):  
Benjamin Bakall ◽  
Lihua Y. Marmorstein ◽  
George Hoppe ◽  
Neal S. Peachey ◽  
Claes Wadelius ◽  
...  
Keyword(s):  
Normal Mouse ◽  
Mouse Development

gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development

1993 ◽  
Vol 196 (2) ◽  
pp. 91-102 ◽  
Author(s):  
David Walterhouse ◽  
Maqbool Ahmed ◽  
Diane Slusarski ◽  
Julie Kalamaras ◽  
Diane Boucher ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Zinc Finger ◽  
Normal Mouse ◽  
Mouse Development ◽  
Zinc Finger Transcription Factor

scholarly journals Sumo-1 Function Is Dispensable in Normal Mouse Development

2008 ◽  
Vol 28 (17) ◽  
pp. 5381-5390 ◽  
Author(s):  
Fu-Ping Zhang ◽  
Laura Mikkonen ◽  
Jorma Toppari ◽  
Jorma J. Palvimo ◽  
Irma Thesleff ◽  
...  
Keyword(s):  
Normal Mouse ◽  
Wild Type Mouse ◽  
Wild Type ◽  
Mouse Development ◽  
Palate Development ◽  
Mouse Embryo Fibroblasts ◽  
Wild Type Mefs ◽  
And Function ◽  
Old Mice

ABSTRACT To elucidate SUMO-1 functions in vivo, we targeted by homologous recombination the last three exons of the murine Sumo-1 gene. Sumo-1 mRNA abundance was reduced to one-half in heterozygotes and was undetectable in Sumo-1 −/− mice, and SUMO-1-conjugated RanGAP1 was detectable in wild-type mouse embryo fibroblasts (MEFs) but not in Sumo-1 −/− MEFs, indicating that gene targeting yielded Sumo-1-null mice. Sumo-1 mRNA is expressed in all tissues of wild-type mice, and its abundance is highest in the testis, brain, lungs, and spleen. Sumo-2 and Sumo-3 mRNAs are also expressed in all tissues, but their abundance was not upregulated in Sumo-1-null mice. The development and function of testis are normal in the absence of Sumo-1, and Sumo-1 − / − mice of both sexes are viable and fertile. In contrast to a previous report (F. S. Alkuraya et al., Science 313:1751, 2006), we did not observe embryonic or early postnatal demise of Sumo-1-targeted mice; genotypes of embryos and 21-day-old mice were of predicted Mendelian ratios, and there was no defect in lip and palate development in Sumo-1 +/− or Sumo-1 −/− embryos. The ability of Sumo-1 −/− MEFs to differentiate into adipocyte was not different from that of wild-type MEFs. Collectively, our results support the notion that most, if not all, SUMO-1 functions are compensated for in vivo by SUMO-2 and SUMO-3.

c-Jun is essential for normal mouse development and hepatogenesis

Nature ◽  
1993 ◽  
Vol 365 (6442) ◽  
pp. 179-181 ◽  
Author(s):  
Frank Hilberg ◽  
Adriano Aguzzi ◽  
Norma Howells ◽  
Erwin F. Wagner
Keyword(s):  
Normal Mouse ◽  
Mouse Development

scholarly journals Blastomeres arising from the first cleavage division have distinguishable fates in normal mouse development

Development ◽  
2001 ◽  
Vol 128 (19) ◽  
pp. 3739-3748 ◽  
Author(s):  
Karolina Piotrowska ◽  
Florence Wianny ◽  
Roger A. Pedersen ◽  
Magdalena Zernicka-Goetz
Keyword(s):  
Inner Cell Mass ◽  
Angular Displacement ◽  
Cell Mass ◽  
Boundary Region ◽  
Lineage Tracing ◽  
Mouse Development ◽  
Cleavage Division ◽  
Cell Stage ◽  
Early Embryos ◽  
Cell Mouse Embryo

Two independent studies have recently suggested similar models in which the embryonic and abembryonic parts of the mouse blastocyst become separated already by the first cleavage division. However, no lineage tracing studies carried out so far on early embryos provide the support for such a hypothesis. Thus, to re-examine the fate of blastomeres of the two-cell mouse embryo, we have undertaken lineage tracing studies using a non-perturbing method. We show that two-cell stage blastomeres have a strong tendency to develop into cells that comprise either the embryonic or the abembryonic parts of the blastocyst. Moreover, the two-cell stage blastomere that is first to divide will preferentially contribute its progeny to the embryonic part. Nevertheless, we find that the blastocyst embryonic-abembryonic axis is not perfectly orthogonal to the first cleavage plane, but often shows some angular displacement from it. Consequently, there is a boundary zone adjacent to the interior margin of the blastocoel that is populated by cells derived from both earlier and later dividing blastomeres. The majority of cells that inhabit this boundary region are, however, derived from the later dividing two-cell stage blastomere that contributes predominantly to the abembryonic part of the blastocyst. Thus, at the two-cell stage it is already possible to predict which cell will contribute a greater proportion of its progeny to the abembryonic part of the blastocyst (region including the blastocyst cavity) and which to the embryonic part (region containing the inner cell mass) that will give rise to the embryo proper.

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