Faculty Opinions recommendation of Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis.

2001 ◽  
Author(s):  
Chaya Kalcheim
Keyword(s):  
Cell Division ◽  
Neural Crest ◽  
Lateral Inhibition ◽  
Neural Crest Cells ◽  
Fate Determination ◽  
Asymmetrical Cell Division

Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis

Development ◽  
2000 ◽  
Vol 127 (13) ◽  
pp. 2811-2821 ◽  
Author(s):  
Y. Wakamatsu ◽  
T.M. Maynard ◽  
J.A. Weston
Keyword(s):  
Cell Division ◽  
Neural Crest ◽  
Glial Cells ◽  
Dorsal Root Ganglia ◽  
Lateral Inhibition ◽  
Dorsal Root ◽  
Neural Crest Cells ◽  
Environmental Cues ◽  
Fate Determination

Avian trunk neural crest cells give rise to a variety of cell types including neurons and satellite glial cells in peripheral ganglia. It is widely assumed that crest cell fate is regulated by environmental cues from surrounding embryonic tissues. However, it is not clear how such environmental cues could cause both neurons and glial cells to differentiate from crest-derived precursors in the same ganglionic locations. To elucidate this issue, we have examined expression and function of components of the NOTCH signaling pathway in early crest cells and in avian dorsal root ganglia. We have found that Delta1, which encodes a NOTCH ligand, is expressed in early crest-derived neuronal cells, and that NOTCH1 activation in crest cells prevents neuronal differentiation and permits glial differentiation in vitro. We also found that NUMB, a NOTCH antagonist, is asymmetrically segregated when some undifferentiated crest-derived cells in nascent dorsal root ganglia undergo mitosis. We conclude that neuron-glia fate determination of crest cells is regulated, at least in part, by NOTCH-mediated lateral inhibition among crest-derived cells, and by asymmetric cell division.

Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system

2014 ◽  
Vol 26 (4) ◽  
pp. 673-682 ◽  
Author(s):  
Maulilio John Kipanyula ◽  
Wahabu Hamisi Kimaro ◽  
Faustin N. Yepnjio ◽  
Yousef H. Aldebasi ◽  
Mohammed Farahna ◽  
...  
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Signaling Pathways ◽  
Peripheral Nervous System ◽  
Neural Crest Cells ◽  
Fate Determination

Induction of melanocyte precursors from neural crest cells surrounding the neural tube-like structures developed in vitro using mouse ES cell culture

2007 ◽  
Vol 27 (1) ◽  
pp. 45-52
Author(s):  
Koh-ichi Atoh ◽  
Manae S. Kurokawa ◽  
Hideshi Yoshikawa ◽  
Chieko Masuda ◽  
Erika Takada ◽  
...  
Keyword(s):  
Cell Culture ◽  
Neural Crest ◽  
Neural Tube ◽  
Neural Crest Cells ◽  
Es Cell ◽  
Mouse Es Cell
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