STUDY THE STATUS USING IMMUNOSUPRESSANTS, SIDE EFFECTS OF IMMUNOSUPRESSANTS AND COMPLICATIONS ON RENAL TRANSPLATATION PATIENTS

2015 ◽  
pp. 39-44
Author(s):  
Tam Vo ◽  
Thi Hong Van Le ◽  
Thi Loc Nguyen
Keyword(s):  
Renal Transplantation ◽  
Side Effects ◽  
Life Quality ◽  
Key Words Renal Transplantation ◽  
Cross Sectional ◽  
Urinary Infections ◽  
Study Results ◽  
The Status ◽  
Centre Hospital ◽  
Stage Renal Disease

Renal transplantation is the most effective therapy in treatment the end stage renal disease. Donated kidney can be transplanted from living donors or brain dead donors renal transplantation reduces the mortality and life quality versus hemodialysis. HLA gene is the most basic examination in renal transplantation. Objectives: to study the status of using the immunosupressants, side effects of immunosuppressants and complications on renal transplantation patients. Materials and Methods: 66 patients at Hue Centre Hospital from 11/2013 - 9/2014 . A Cross-sectional and prospective study. Results and conclusions: 3 patients had acute renal rejection and 4 patients had chronic renal rejection. The complications in the groups transphlanted over 1 years were diabietes, diarrhea, varicella, thrombopenia. Hyperuricemia was 39.4%, drugs hepatitis was 12.1%. After renal transplantation, were 13.6% had urinary infections, no case of heart failure was domanted. Key words: renal transplantation, immunosuppressants, complications.

STUDY THE DYSLIPIDEMIA AND THE EFFECTIVENESS OF TREATMENT IN PATIENT AFTER RENAL TRANSPLANTATION AT HUE CENTRAL HOSPITAL

2016 ◽  
pp. 58-65
Author(s):  
Tam Vo ◽  
Thi Thuy Linh Nguyen ◽  
Thi Loc Nguyen ◽  
Thanh Minh Nguyen
Keyword(s):  
Kidney Transplantation ◽  
Renal Transplantation ◽  
Hdl Cholesterol ◽  
Immunosuppressive Drugs ◽  
Key Words Renal Transplantation ◽  
Central Hospital ◽  
Related Factors ◽  
Cross Sectional ◽  
Remarkable Effect ◽  
Study Results

Objectives: Survey proportion of dyslipidemia and related factors in after kidney transplantation. Assess the efficancy and side effects of atorvastatin in hyperlipidemia after renal transplantation. Materials and Methods: 43 patients received a kidney transplantation at Hue central Hospital from 06/2013-08/2015.And 26 hyperlipidemia renal transplant recipents was administered with atorvastatin 10mg/day for a period of 2 months base on guideline treatment of NCEC 1991 (National Cholesterol Education Council). A Cross-sectional and prospective study. Results: new-onset dyslipidemia incidence after renal transplantation was 97.7%. Dyslipidemiatreatement base on recommend NCECwas 60.5%.The regimen 1(Neoral+ Cellcept+Prednisolon) and 2 (Prograf+ Cellcept+Prednisolon) have similar effect on change serum lipid before and after transplantation 1 month (p<0.05).On average, serum total cholesterol and serum LDL cholesterol and triglyceride significantly decreased after atorvastatin therapy (p<0.05). Whereas, serum HDL cholesterol also decreased. Renal function, creatinin clearance, transamina, creatinin phosphokinase, CRP, fasting glucose, urine protein without significant changes during the period on atorvastatin. Adverse effects were reported in three cases (2 case increase transamin and 1 case increase creanin phosphokinase). But there was no evidence of myopathy, including myalgia. All events were mild and treatment did not need to be discontinued in any of the case. Elevated transamina and CK spontaneous resolution, even the Atorvastatin is continued. Conclusion: Dyslipidemia met with high rates after transplant and showed no difference in the regimens using immunosuppressive drugs cause this disorder. Treatment with atorvastatin 10 mg / day has remarkable effect of dyslipidemia in patients after renal transplantation. Key words: renal transplantation, immunosuppressive drugs, dyslipidemia.

scholarly journals Calcium Metabolism following Renal Transplantation

1994 ◽  
Vol 31 (2) ◽  
pp. 125-128 ◽  
Author(s):  
Anne M Straffen ◽  
DJS Carmichael ◽  
Angela Fairney ◽  
B Hulme ◽  
M Snell
Keyword(s):  
Renal Transplantation ◽  
Calcium Homeostasis ◽  
End Stage Renal Disease ◽  
Post Transplantation ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Transplant Patients ◽  
The Status ◽  
Stage Renal Disease ◽  
End Stage

Abnormalities of calcium homeostasis are a recognized feature of end-stage renal disease. The treatment of choice is renal transplantation, but this does not always result in normalization of the biochemical profile. Persistent hypercalcaemia is well documented and our study was undertaken to investigate the status of the calcium regulating hormones in renal patients post-transplantation. Serum calcium, parathyroid hormone, 1,25-dihydroxyvitamin D (1,25(OH)2D) and osteocalcin concentrations were measured in post-transplant patients. Twenty per cent of the patients had subnormal 1,25(OH)2D concentrations while 55% had biochemical evidence of hyperparathyroidism but only 5% were hypercalcaemic. Time elapsed since transplantation was not correlated with any of the analytes investigated and there was no relationship between persistent impairment of renal function and abnormalities of calcium homeostasis.

scholarly journals Geographic and Seasonal Variation of Vitamin D: A Retrospective Study in Two Centers of Nepal

2020 ◽  
Vol 18 (1) ◽  
pp. 103-107
Author(s):  
Arun Sedhain ◽  
Gandhi R Bhattarai ◽  
Sanjaya Raya Yadav ◽  
Bhupendra Raj Pandey ◽  
Thakur Prasad Pant
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Winter Season ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Age Group ◽  
Cross Sectional ◽  
Study Results ◽  
The Status

Background: Vitamin D deficiency is a common problem in many countries throughout the world. This study aimed at understanding the status of vitamin D deficiency in relation to age, gender, geography and season among relatively bigger numbers of population residing in central and western regions of Nepal.Methods: This retrospective cross-sectional study was carried out by reviewing the records of vitamin D tests in two centers of Nepal- namely united reference laboratories at Pokhara and Chitwan Medical College at Chitwan. A total of 3320 individuals who were tested for clinical suspicion of vitamin D deficiency over a period of one year were included in the study. Results: Mean vitamin D level was 18.7 ng/mL. Majority of subjects tested for vitamin D were females (71.36 %) with female to male ratio of 2.49:1. Hypovitaminosis D (? 30 ng/mL) was found in 84.5% subjects and was moderate to severely deficit (<10 ng/mL) in 25.9% of subjects. Status of hypovitaminosis D was found to be less in ?50 years (79.9%) than the younger subjects (89.9% in ?18 years and 87.0% in 19-49 years age group). Vitamin D deficiency was found lower in hills districts (80.8% vs 89.7% in the plains), which was found to be more pronounced during winter through summer seasons as compared to fall season.Conclusions: Population residing in plain areas and summer, spring and winter season are found to have increased problem of Hypovitaminosis D. It is also found to be common among younger children and female of reproductive age group. We have also found out the increased problem of hypovitaminosis D among population residing in the plain areas than in the hills especially in the summer, spring and winter season.Keywords: Geographic variation; hypovitaminosis D; Nepal

scholarly journals Awareness, Attitude, and Current Practices Toward Influenza Vaccination Among Physicians in India: A Multicenter, Cross-Sectional Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Agam Vora ◽  
Ashfaque Shaikh
Keyword(s):  
Side Effects ◽  
High Risk ◽  
Influenza Vaccination ◽  
Practice Patterns ◽  
Risk Groups ◽  
Influenza Vaccines ◽  
Physician Specialty ◽  
Cross Sectional ◽  
Study Results ◽  
Current Practices

Background: Although annual influenza vaccination is recommended for healthcare providers (HCPs), vaccination rate among HCPs in India is generally low. This cross-sectional survey was conducted to evaluate physicians' awareness, attitude, and current practices toward influenza vaccination in high-risk groups in India.Methods: The survey was performed in June–July 2020, wherein consulting physicians, pulmonologists, diabetologists, obstetricians/gynecologists, or cardiologists across 14 cities completed a 39-item questionnaire consisting of 3 sections, one each on awareness, attitude, and practice patterns. Descriptive statistics were used to summarize the study results. Statistical analysis was performed for comparison of subgroups by physician specialty, city of practice (metro/non-metro), and zone of practice (north/south/east/west). Level of statistical significance was set at p &lt; 0.05.Results: In all, 780 physicians completed the survey. Of these, 3.97, 53.08, and 42.95% had high, medium, and low level of awareness about influenza/influenza vaccination, respectively. Statistically significant (p &lt; 0.05) between-group differences were found by physician specialty and zone of practice. In terms of attitude toward vaccination of high-risk group subjects, only 0.9% physicians were “extremely concerned,” while the majority (92.56%) were “quite concerned” and 6.54% were a “little concerned,” with no reported significant differences between different subgroups. With regard to practice patterns, 82.82% of physicians offered influenza vaccines to their patients, 32.69% vaccinated 10–25% of patients per month, and 38.85% required and offered the vaccine to their office staff. Physicians' reasons for not prescribing influenza vaccines to patients included fear of side effects (16.54%), cost (15.64%), lack of awareness about availability (15.38%), absence of belief that it is beneficial (14.36%), history of side effects (13.46%), and patients' fear of needles (11.28%).Conclusion: These findings suggest the need to implement educational strategies among physicians to enhance their awareness about influenza vaccination and improve their attitudes and current practices toward influenza vaccination especially in high-risk groups in India.

MO864PATIENT MEDICATION ADHERENCE ON HEMODIALYSIS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Marwa Omrane ◽  
Amel Babchia ◽  
Raja Jaballah ◽  
Afef Mahersia ◽  
Olfa Saidane
Keyword(s):  
Side Effects ◽  
Cross Sectional Study ◽  
Chronic Hemodialysis ◽  
Therapeutic Education ◽  
Maintenance Hemodialysis ◽  
Adherence To Treatment ◽  
Cross Sectional ◽  
Adherence Assessment ◽  
The Mean ◽  
Stage Renal Disease

Abstract Background and Aims Non-adherence to treatment is a major problem in patients with end stage renal disease and contributes to the significant increase in morbidity, mortality and health costs. Method The objective of this work was to assess adherence to treatment prescriptions for hemodialysis patients and to identify the predictive factors of poor compliance. This is a cross-sectional study of 59 patients on chronic hemodialysis. Adherence to treatment was evaluated by the adherence assessment test. Results The mean age of our patients was 51.8 years, with an M/F sex ratio of 1.26. The socio-economic level was considered low in 83% of cases. The mean duration of hemodialysis was 81.6 months [6 months-252 months]. Causal nephropathy was dominated by vascular nephropathy (13 cases). Forty-two patients had high blood pressure. A total of 23.9% of patients were good observers, 59.5% had minimal compliance problems, and 16.7% were poor observers. Statistical analysis has shown that poor adherence to treatment is associated with male gender, low socioeconomic and intellectual level, the presence of comorbidities, increased medication, number of medications taken per day, and less knowledge of the pathology and risks as side effects of drugs. Conclusion Treatment adherence is unsatisfactory in our population of patients on maintenance hemodialysis. Therapeutic education targeting the expected benefit of the treatments, their mode of action, their side effects as well as a simplification of the intake would improve long-term adherence in patients.

scholarly journals Frequency of anemia in patients with increased level of parathyroid hormone among patients on maintenance hemodialysis.

2020 ◽  
Vol 27 (06) ◽  
pp. 1255-1258
Author(s):  
Saad Muzaffar Azeem ◽  
Anita Haroon ◽  
Ishtiaque Alam ◽  
Sadia Azeem ◽  
Mahrukh Sultana ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Maintenance Hemodialysis ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Study Results ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage

Objectives: One of the most frequently occurring complication of end stage renal disease is anemia. It can be defined as decrease in red blood cells with hemoglobin concentration less than 12 g/dl in women and less than 13 g/dl in men. Parathyroid hormone levels are also raised among patients with end stage renal disease to maintain serum calcium levels. The objective of this study is to evaluate the degree of anemia in patients with end stage renal disease currently on maintenance hemodialysis and have raised PTH levels. Study Design: Cross-sectional study. Setting: Kidney Center, Karachi. Period: November 2015 to July 2016. Material & Method: Patients undergoing maintenance hemodialysis during the study duration with PTH levels greater than 300 ng/L were included in the study. Patients with other co-morbid conditions like chronic liver disease and hypersplenism were excluded from the study. Results: The total number of patients on maintenance hemodialysis in the kidney center that matched our inclusion criteria was 110. Amongst them there were 47.3% (n=52) males and 52.7% (n=58) females. The mean age of patients in our study is 50.15 ± 12.92 years. The mean PTH level of patients was found to be 642 ± 405.9U. Since all the participants of the study are on maintenance dialysis, the mean duration of hemodialysis was found to be 4.2 ± 3.19 months. The mean hemoglobin level of patients was found to be 9.75 ± 1.47 g/dl. Conclusion: Patients with hyperparathyroidism and undergoing maintenance hemodialysis frequently develops anemia. Many factors account for this including raised PTH levels causing bone marrow fibrosis, decreased production of erythropoietin and resistance of produced erythropoietin are some factors responsible for the anemia.

scholarly journals The Relationship Between Dialysis Adequacy And Fatigue In Patients On Maintenance Hemodialysis

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Sri Suparti ◽  
Sodikin Sodikin ◽  
Endiyono Endiyono
Keyword(s):  
Life Quality ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
P Value ◽  
Dialysis Adequacy ◽  
Cross Sectional ◽  
Severe Fatigue ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage

Fatigue and inadequacy dialysis are common problem in hemodialysis patients. The dialysis inadequacy can cause an increased progression of impaired renal function, as well as the increased morbidity and mortality, and declining productivity of hemodialysis patients. Fatigue prevalence ranged from 44,7- 97% from mild to severe. Fatigue is a common complaint of hemodialysis patients that can lower physical function and life quality. To determine the correlation between adequacy and the fatigue level of the patients with End Stage Renal Disease (ESRD) undergoing hemodialysis. This study used a descriptive analytic and cross sectional approach involving 75 respondents and the FACIT-G Questionnaire was used to collect the data. The inclusion criteria are male and female patients aged 18 -70, undergoing hemodialysis for more than 3 months with a frequency of 2 times at least 4 hours, composmentis patients. The adequacy hemodialysis was assessed using the Kt/V formula. All data were collected during the session of hemodialysis. Pearson Product moment test wes used to analyze the data. The mean dialysis adequacy was 1.43±0.380, 57(76%) only 13 (17.3%) patients had adequate dialysis (minimum laboratory standard Kt / v = 1.8) and inadequate were 62 (82.7%) patients. The mean of fatigue was 20.07 and 62 (82.7%) respondents experienced severe fatigue. There was no significant correlation between adequacy and the fatigue level of the patients with ESRD undergoing hemodialysis with p value 0.504 (α> 0.05). Mostly patients had inadequate dialysis, both adequate and inadequate dialysis patients had experience fatigue from mild to severe. Multiple individuale and personnel factors affect dialysis adequacy directly or conversely.

scholarly journals Global Impact of Obesity and Diabetes on the Increase Incidence and Prevalence of Chronic Kidney disease (CKD) and End Stage Renal Disease (ESRD): A Systematic Review

2021 ◽  
Author(s):  
Asmatullah kakar ◽  
Niamatullah Kakar ◽  
Anne-Claire Durand ◽  
Yosra Mouelhi ◽  
Stephanie Gentile
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplantation ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Case Control ◽  
Cross Sectional ◽  
Obesity And Diabetes ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Abstract Background: Obesity and diabetes are the main causes of chronic kidney disease (CKD) and end stage renal disease (ESRD). The objective of this study was to analyze the impact of obesity and diabetes on CKD and ESRD incidence and prevalence. Methods: A comprehensive literature search was conducted from 2001 to 2018. 494 articles were retrieved via PubMed and 125 articles through Google scholar and reference list of the selected articles. Among which thirty (30) studies met our inclusion criteria consisting of 17 cohorts, 11 cross-sectional, and 2 case-control studies.Results: Majority of the studies indicated direct relationship between body mass index (BMI) and ESRD risk. Notably, the association of obesity and diabetes potentially increases the incidence and prevalence of CKD and ESRD. Results from the cohort, case-control and cross-sectional studies pointed out a positive association between obesity, diabetes and risks for renal disease outcomes. Even though many complications may occur, renal transplantation (RT) is still the preferred renal replacement therapy (RRT) advised in multiple studies for diabetic ESRD patients. Renal transplantation was associated with better quality of life and survival advantage than dialysis. Interestingly, overweight and obese ESRD patients on dialysis had a significant survival advantage in comparison to lean body weight patients. Conclusion: Taken together, obesity and diabetes are significantly associated with the increasing incidence and prevalence of CKD and ESRD. Regulation of Weight and diabetes are highly recommended in obese and diabetic patients to prevent the subsequent renal disease. Previous reviews have discussed the relationship between obesity and ESRD or diabetes and ESRD separately. However, importantly, this review gives an insight on the association between obesity, diabetes and CKD/ ESRD.

Assessment of The Immediate Side Effects of Covid-19 Vaccination Among The People of Pakistan

2021 ◽  
Vol 15 (10) ◽  
pp. 3076-3079
Author(s):  
Ibtesam-E- Fajar ◽  
Hina Aslam ◽  
Nimra Ijaz ◽  
Daniyal Ahmed ◽  
Amna Sarfraz ◽  
...  
Keyword(s):  
Side Effects ◽  
Analysis Data ◽  
Cross Sectional Study ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Post Vaccination ◽  
The People ◽  
Study Results ◽  
Study Methodology ◽  
And Gender

The Covid-19 pandemic has wreaked havoc throughout the world, with 150 million cases to date and over 3 million lives claimed worldwide Objectives: To assess the immediate side effects of Covid-19 vaccination among the people of Pakistan Study Design: Randomized, descriptive cross-sectional study Methodology: Present study was carried out using an online questionnaire by enrolling 17040 subjects. Inclusion/Exclusion criteria: All citizens of Pakistan over the age of 12, who were eligible for the COVID-19 vaccination were enrolled. Statistical analysis: Data was analyzed by SPSS software, version 25 in terms of frequencies and percentages. Results: In present study, results showed that 76% subjects were vaccinated. Among them 64% received Sinopharm, 30% Sinovac, 0.7% Pfizer, 0.5% Astrazeneca, 2.8% Moderna, 0.8% Cansino, 0.3% PakVac and 0.1% Sputnik V. Most participants (66%) suffered no symptoms post vaccination. Only 15% developed fever, 7% dizziness, 5% vomiting, 4% pain at injection site, 2% headache and 1% fatigue. After vaccination, 1% had a re-infection and 99% so far have not caught Covid-19. Among all participants, 87% found the vaccine safe, 7% were neutral and 5% found it unsafe. Conclusion: We concluded that most Pakistanis have received the Chinese vaccine i.e. Sinopharm. Majority individuals have experienced either no to mild or few moderate type of adverse effects following immunization irrespective of the age and gender that can be easily managed at home. Key Words: COVID-19, Vaccination, Awareness and Adverse Effec

STUDY ON THE STATUS OF LOWER GENITAL TRACT INFECTIONS AMONG MINORITY ETHNIC ADOLESCENT GIRLS IN A LUOI DISTRICT, THUA THIEN HUE PROVINCE

2018 ◽  
pp. 210-217
Author(s):  
Nguyen Dieu Trang Dao ◽  
Thi Bich Ngoc Phan ◽  
Vu Quoc Huy Nguyen
Keyword(s):  
Adolescent Girls ◽  
Genital Tract ◽  
Cross Sectional Study ◽  
Genital Tract Infection ◽  
Cross Sectional ◽  
Lower Genital Tract ◽  
Study Results ◽  
The Status ◽  
Genital Tract Infections ◽  
Tract Infections

Objectives: To describe the knowledges, attitudes, practices of preventing lower genital tract infections among adolescent girls in A Luoi district, Thua Thien Hue province and identify the percentage lower genital tract infections among adolescent girls. Methods: A cross-sectional study design was conducted in A Luoi district, Thua Thien Hue province. All 960 adolescent girls between 10 – 19 years old of 8 communes in A Luoi district participated in the study. Results: The percentage of adolescents who do not know about symptom of lower genital tract infections were 71.6%. The percentage of adolescents who know itchy symptom were 21.3%. The percentage of adolescents who do not know the factors to cause disease were 51.9%. 34.1% adolescents who know poor menstrual hygien, 31.9% know poor hygien daily. - The percentage of adolescents who do not know the methods to prevent lower genital tract infections were 42.2%. The percentage of adolescents who know to go to health center when they have symptoms were 76.1%, however still have 31% adolescents do not know how will they do when they have symptoms. The percentage of adolescents who know there is need to education for them to prevent lower genital tract infections. 87.1% adolescents use fresh water to wash and hygien daily. 98.4% adolescents do genital hygien. The percentage of lower genital tract infections in adolescents was 2.2%. Conclusion: The knowledge of lower genital tract infection among adolescent girls are not good. The percentage of lower genital tract infections in adolescents was 2.2%. Key words: lower genital tract infections, A Luoi district, Thua Thien Hue province

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