ANTIBIOTIC-RESISTANCE OF HELICOBACTER PYLORI: EPIDEMIOLOGY DIAGNOSIS AND TREATMENT

2012 ◽  
pp. 5-15
Author(s):  
Ngoc Quy Hue Dang ◽  
Van Huy Tran
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Treatment Regimen ◽  
Antibiotic Susceptibility ◽  
Susceptibility Testing ◽  
Antibiotic Susceptibility Testing ◽  
Ulcer Disease

Successful eradicative treatment of H.pylori will reduce the recurrence rate of peptic ulcer disease and the risk of gastric cancer. In our country, the indication of antibiotics for both H.pylori-induced and non-H.pylori-induced diseases has been so available that it has increased H.pylori antibiotic resistance which decreased the efficacy of H.pylori treatment. Some national researches have shown that the rate of H.pylori resistance to Clarithromycin is higher than 20%. For H.pylori-infected patients in whom two empirical regimens fail to eradicate H.pylori, it is necessary to perform culture and antibiogram so that doctors will choose which treatment regimen is suitable for them. Among the H.pylori antibiotic susceptibility testing, the Epsilometer test is both less effort and accurate. H.pylori treatment should be not only standardized and updated according to Maastricht Consensus IV-2012 but also strengthened the management of key antibiotics in H.pylori treatment.

The Effect of Eradicating Helicobacter Pylori on the Development of Gastric Cancer in Patients with Peptic Ulcer Disease

2005 ◽  
Vol 100 (5) ◽  
pp. 1037-1042 ◽  
Author(s):  
Susumu Take ◽  
Motowo Mizuno ◽  
Kuniharu Ishiki ◽  
Yasuhiro Nagahara ◽  
Tomowo Yoshida ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Ulcer Disease ◽  
Development Of Gastric Cancer

scholarly journals The Human Gastric Pathogen Helicobacter pylori and Its Association with Gastric Cancer and Ulcer Disease

Ulcers ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-23 ◽  
Author(s):  
Bianca Bauer ◽  
Thomas F. Meyer
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Strain Differences ◽  
Protective Effects ◽  
Ulcer Disease ◽  
Prophylactic Measures ◽  
H Pylori

With the momentous discovery in the 1980's that a bacterium, Helicobacter pylori, can cause peptic ulcer disease and gastric cancer, antibiotic therapies and prophylactic measures have been successful, only in part, in reducing the global burden of these diseases. To date, ~700,000 deaths worldwide are still attributable annually to gastric cancer alone. Here, we review H. pylori's contribution to the epidemiology and histopathology of both gastric cancer and peptic ulcer disease. Furthermore, we examine the host-pathogen relationship and H. pylori biology in context of these diseases, focusing on strain differences, virulence factors (CagA and VacA), immune activation and the challenges posed by resistance to existing therapies. We consider also the important role of host-genetic variants, for example, in inflammatory response genes, in determining infection outcome and the role of H. pylori in other pathologies—some accepted, for example, MALT lymphoma, and others more controversial, for example, idiopathic thrombocytic purpura. More recently, intriguing suggestions that H. pylori has protective effects in GERD and autoimmune diseases, such as asthma, have gained momentum. Therefore, we consider the basis for these suggestions and discuss the potential impact for future therapeutic rationales.

Helicobacter pylori in Gastric Cancer and Peptic Ulcer Disease in a Colombian Population. Strain Heterogeneity and Antibody Profiles

Helicobacter ◽  
2001 ◽  
Vol 6 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Diana M. Cittelly Pineros ◽  
Sandra C. Henao Riveros ◽  
Julian D. Martinez Marin ◽  
Oliveros Ricardo ◽  
Oscar Orozco Diaz
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Ulcer Disease

scholarly journals Proinflammatory cytokines and thrombomodulin in patients with peptic ulcer disease and gastric cancer, infected with Helicobacter pylori

2011 ◽  
Vol 54 (1) ◽  
pp. 103 ◽  
Author(s):  
Mahsa Molaei ◽  
Reza Mashayekhi ◽  
Homayoun Zojaji ◽  
MohammadAmin Pourhoseingholi ◽  
Tina Shooshtarizadeh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Proinflammatory Cytokines ◽  
Ulcer Disease
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