LONG - TERM RESULTS FROM CURABLE GASTRECTOMY AND D2, D3 LYMPHADENECTOMY IN GASTRIC CANCER TREATMENT

2012 ◽  
pp. 80-85
Author(s):  
Manh Ha Le ◽  
Quang Bo Nguyen
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Tnm Classification ◽  
Subtotal Gastrectomy ◽  
Long Term Results ◽  
D3 Lymphadenectomy ◽  
Third Stage ◽  
Keywords Gastric Cancer ◽  
Centre Hospital

Objectives: Evaluation of pathological characteristics, motality rate and five-year survival rate from curable gastrectomy and D2, D3 lymphadenectomy in gastric cancer at Hue Centre Hospital. Materials and methods: Consist of 119 patients underwent curable gastrectomy and D2, D3 lymphadenectomy from May 2005 to May 2012. Results: Age: average 56.2 ± 11.8 (19-81), male/female 1.83/1. Distal subtotal gastrectomy 88.24%, total gastrectomy 7.56%, proximal subtotal gastrectomy 4.2% Lymphadenectomy: D2 62.18%, D3 37.82%. TNM classification: first stage 4.20%, second stage 29.41%, third stage 61.34% và fourth stage 5.04%. Intraoperative splenic rupture was the most common 5.88%, overall five-year survival rate 28.8%, overall D2 five-year survival rate 47.9%; overall D3 five-year survival rate 63.1% (not significant with p = 0.1137) and non relatively operative motality. Conclusion: Curable gastrectomy and D2, D3 lymphadenectomy in gastric cancer is safety, five-year survival rate is long-term, and oncologically effective procedure. Keywords: Gastric cancer, Gastrectomy, D2, D3 Lymphadenectomy. Key words: Gastric cancer, Gastrectomy, D2, D3 Lymphadenectomy

PROSPECTIVE NON-RANDOMIZED CASE-CONTROL STUDY: IMMEDIATE RESULTS OF RADICAL LAPAROSCOPIC INTERVENTIONS FOR GASTRIC CANCER, THE EXPERIENCE OF A SINGLE CENTER

2017 ◽  
Vol 63 (2) ◽  
pp. 247-255
Author(s):  
Aleksey Karachun ◽  
Yuriy Pelipas ◽  
Pavel Sapronov ◽  
O. Kozlov ◽  
D. Asadchaya
Keyword(s):  
Gastric Cancer ◽  
Tnm Classification ◽  
Long Term Results ◽  
Control Group ◽  
R0 Resection ◽  
7Th Edition ◽  
Results Of Treatment ◽  
Oncology Center

The aim of this study was to define safety and oncological adequacy of radical laparoscopic interventions in gastric cancer (GC) in the conditions of a specialized oncology center. Materials and methods. The study included 193 (108 men and 85 women) with a histologically verified gastric adenocarcinoma of varying degrees of differentiation or cricoid-cell carcinoma with stage T1b-T4a cN0-N1 according to the UICC / TNM classification (7th edition). The study was prospective. The main group (laparoscopic interventions) included 81 patients: 54 underwent distal subtotal resections of the stomach (DSRS) and 27 underwent gastrectomies (GE); 101 patients (66 DSRSs and 35 GEs) contained the control group (open interventions). Separate group of 11 patients were with a conversion access. Results. The average duration of the laparoscopic DSRS was 209.6 ± 50.4 minutes, the open DSRS - 168.9 ± 44.1 minutes (p <0.05). The mean duration of laparoscopic GE was 241.7 ± 60.3 min, while the open GE was 185.1 ± 48.9 min (p <0.05). The average volume of intraoperative blood loss for laparoscopic DSRS was 100 ± 65.4 ml, with open DSRS - 217.4 ± 102.5 ml (p <0.05) and for laparoscopic and open GE it was 105.5 ± 45.2 ml and 247.1 ± 87.4 ml, respectively (p <0.05). The average number of removed lymph nodes in laparoscopic DSRS was 24,7 ± 5,1, with open DSRS - 25,4 ± 6,7 (p> 0,05), while in laparoscopic and open GE it was 25,1 ± 6, 4 and 26.8 ± 5.3, respectively (p> 0.05). In all cases of laparoscopic interventions R0 resection was performed. In the structure of postoperative complications the specific gravity of severe complications (IIIb - V degree according to the classification of Clavien-Dindo) in the subgroup of laparoscopic DSRS was 5.6%, in the subgroup of open DSRS - 6% (p> 0.05), and in subgroups of laparoscopic and open GE - 11.1% and 8.6%, respectively (p> 0.05). Postoperative lethality in the group of laparoscopic interventions was 1.2%, in the open surgery group - 2.9% (p> 0.05). The analysis of training curves in the performance of laparoscopic interventions demonstrated that the experience of 30 laparoscopic DSRSs and 15 laparoscopic GEs did not allow promoting an access to the plateau but it demonstrated the trend in reducing the duration of operations when accumulating experience. Conclusions. Radical laparoscopic operations for stomach cancer are safe and oncologically adequate. The absence of long-term results of treatment dictates the necessity of continuing the study.

scholarly journals Long-Term Survival of Two Patients with Liver Metastases from Advanced Gastric Cancer Treated with Radiofrequency Ablation and Chemotherapy

2021 ◽  
pp. 67-72
Author(s):  
Sung Jin Oh
Keyword(s):  
Gastric Cancer ◽  
Radiofrequency Ablation ◽  
Liver Metastases ◽  
Advanced Gastric Cancer ◽  
Systemic Chemotherapy ◽  
Subtotal Gastrectomy ◽  
Hepatic Metastases ◽  
Term Survival ◽  
Long Term Survival

Liver metastasis from gastric cancer has a very poor prognosis. Herein, we present two cases of liver metastases (synchronous and metachronous) from advanced gastric cancer. In the first case, the patient underwent radical subtotal gastrectomy. Liver metastases occurred 6 months after surgery while the patient was receiving adjuvant chemotherapy, but two hepatic tumors were successfully removed by radiofrequency ablation (RFA). In the second case, liver metastases occurred 15 months after surgery for gastric cancer. The patient also received RFA for one hepatic tumor, and other suspicious metastatic tumors were treated with systemic chemotherapy. Although these case presentations are limited for the efficacy of RFA treatment with systemic chemotherapy for hepatic metastases from gastric cancer, our findings showed long-term survival (overall survival for 108 and 67 months, respectively) of the affected patients, without recurrence. Therefore, we suggest that RFA treatment with systemic chemotherapy could be an effective alternative treatment modality for hepatic metastases from gastric cancer.

scholarly journals Minimum 10-Year Clinical Outcome of Lateral Collagen Meniscal Implants for the Replacement of Partial Lateral Meniscal Defects: Further Results From a Prospective Multicenter Study

2021 ◽  
Vol 9 (5) ◽  
pp. 232596712199491
Author(s):  
Alberto Grassi ◽  
Gian Andrea Lucidi ◽  
Giuseppe Filardo ◽  
Piero Agostinone ◽  
Luca Macchiarola ◽  
...  
Keyword(s):  
Survival Rate ◽  
Case Series ◽  
Final Analysis ◽  
Activity Level ◽  
Long Term Results ◽  
Level Of Evidence ◽  
Unicompartmental Knee Arthroplasties ◽  
Tegner Score

Background: The collagen meniscal implant (CMI) is a biologic scaffold aimed at replacing partial meniscal defects. The long-term results of lateral meniscal replacement have never been investigated. Purpose: To document the clinical outcomes and failures of lateral CMI implantation for partial lateral meniscal defect at a minimum 10-year follow-up. Study Design: Case series; Level of evidence, 4, Methods: This study included 24 consecutive patients who underwent lateral CMI implantation for partial lateral meniscal defects between April 2006 and September 2009 and who were part of a previous study with a 2-year follow-up. Outcome measures at the latest follow-up included the Lysholm score, Knee injury and Osteoarthritis Outcome Score, visual analog scale (VAS) for pain, Tegner activity level, and EuroQol 5-Dimensions score. Data regarding complications and failures were collected, and patients were asked about their satisfaction with the procedure. Results: Included in the final analysis were 19 patients (16 male, 3 female) with a mean age at surgery of 37.1 ± 12.6 years and a mean follow-up of 12.4 ± 1.5 years (range, 10-14 years). Five failures (26%) were reported: 1 CMI removal because of implant breakage and 4 joint replacements (2 unicompartmental knee arthroplasties and 2 total knee arthroplasties). The implant survival rate was 96% at 2 years, 85% at 5 years, 85% at 10 years, 77% at 12 years, and 64% at 14 years. Lysholm scores at the final follow-up were rated as “excellent” in 36% (5 of 14 nonfailures), “good” in 43% (6 of 14), and “fair” in 21% (3 of 14). The VAS score was 3.1 ± 3.1, with only 16% (3 of 19 patients) reporting that they were pain-free; the median Tegner score was 3 (interquartile range, 2-5). All clinical scores decreased from the 2-year follow-up; however, with the exception of the Tegner score, they remained significantly higher compared with the preoperative status. Overall, 79% of patients were willing to undergo the same procedure. Conclusion: Lateral CMI implantation for partial lateral meniscal defects provided good long-term results, with a 10-year survival rate of 85% and a 14-year survival rate of 64%. At the final follow-up, 58% of the patients had “good” or “excellent” Lysholm scores. However, there was a general decrease in outcome scores between the short- and the long-term follow-up.

scholarly journals Impact of the Number of Dissected Lymph Nodes on Survival for Gastric Cancer after Distal Subtotal Gastrectomy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Chang-Ming Huang ◽  
Jian-Xian Lin ◽  
Chao-Hui Zheng ◽  
Ping Li ◽  
Jian-Wei Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Lymph Nodes ◽  
Distal Gastrectomy ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Prognostic Impact ◽  
Term Survival

Objectives. To investigate the prognostic impact of the number of dissected lymph nodes (LNs) in gastric cancer after curative distal gastrectomy.Methods. The survival of 634 patients who underwent curative distal gastrectomy from 1995 to 2004 was retrieved. Long-term surgical outcomes and associations between the number of dissected LNs and the 5-year survival rate were investigated.Results. The number of dissected LNs was one of the most important prognostic indicators. Among patients with comparable T category, the larger the number of dissected LNs was, the better the survival would be (). The linear regression showed that a significant survival improvement based on increasing retrieved LNs for stage II, III and IV (). A cut-point analysis yields the greatest variance of survival rate difference at the levels of 15 LNs (stage I), 25 LNs (stage II) and 30 LNs (stage III).Conclusion. The number of dissected LNs is an independent prognostic factor for gastric cancer. To improve the long-term survival of patients with gastric cancer, removing at least 15 LNs for stage I, 25 LNs for stage II, and 30 LNs for stage III patients during curative distal gastrectomy is recommended.

Long-term Results of Chemotherapy in 106 Cases of Lymphosarcoma and Reticulum Cell Sarcoma

1968 ◽  
Vol 54 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Sergio Di Pietro
Keyword(s):  
Survival Rate ◽  
Alkylating Agents ◽  
Clinical Stage ◽  
Long Term Results ◽  
Reticulum Cell ◽  
Reticulum Cell Sarcoma ◽  
Term Survival ◽  
Cell Sarcoma ◽  
Pre Treatment

The survival rate of 106 cases of advanced lymphosarcoma and reticulum cell sarcoma that had received chemotherapy, with or without radiotherapy, between 1951 and 1962 is reported. The course of both diseases was initially highly malignant, with a median survival of 20 months for lymphosarcoma and 6 months for reticulum cell sarcoma. Cases surviving for over 3 years, however, have a good chance of long survival. Male sex and an age of under 40 (there were no cases of under 13 in our series) seem to be favorable prognostic factors. A long pre-treatment interval is favorable for lymphosarcoma and adverse for reticulum cell sarcoma. The clinical stage (3 or 4 according to the classification of Banfi et al.) does not significantly affect the prognosis of lymphosarcoma whereas in reticulum cell sarcoma survival is strongly correlated with clinical stage. Chemotherapy (with alkylating agents) yielded a 5-year survival rate of 20.8% in lymphosarcoma; with radiotherapy the rate rose to 32.3%. In reticulum cell sarcoma the 5-year survival rate was 20% for chemotherapy alone and 14.2% for chemotherapy in association with radiotherapy. Our data seem to confirm the usefulness of chemotherapy, with or without radiotherapy, in diffuse forms of lymphosarcoma and reticulum cell sarcoma, especially with regard to long-term survival.

scholarly journals Immediate and Long-Term Results of the Spleen-Preserved Operations in the Surgical Treatment of Gastric Cancer

2020 ◽  
Vol 13 (3) ◽  
pp. 227-232
Author(s):  
Marina I. Rogozianskaia ◽  
Alexander Nikolayevich Redkin ◽  
Ivan Petrovich Moshurov
Keyword(s):  
Gastric Cancer ◽  
Surgical Treatment ◽  
Total Gastrectomy ◽  
The Body ◽  
Long Term Results ◽  
D2 Lymphadenectomy ◽  
Spleen Preserving ◽  
Cardiac Region ◽  
Clinically Significant

ntroduction. Currently, total gastrectomy with D2 lymphadenectomy is the standard surgical treatment for proximal gastric cancer at the resectable stages (I-III). The issue of advisability of splenectomy as a component of lymphadenectomy remains a controversial one, especially when the tumor is localized in the region of the body or cardiac region of the stomach.The aim of the study was to compare immediate and long-term outcomes, including the quality of life, between spleen preserving and spleen removing surgeries.Methods. The study included 363 patients with gastric cancer II-III stages, localized in the upper and/or the middle third of the stomach, who underwent surgery at the Voronezh Regional Clinical Oncology Hospital and the Voronezh Clinical Hospital of the Russian Railway-Medicine in 2015-2017. All patients were conditionally divided into 2 groups for comparative retrospective analysis. All patients of the first (experimental or spleen-preserved) group (144 patients) were performed R0 total gastrectomy with D2 lymphadenectomy, including splenic hilar nodes (№ 10,11) removal without splenectomy. Patients of the second (control or splenectomy) group (219 patients) were performed R0 total gastrectomy with D2 lymphadenectomy and prophylactic splenectomy (for splenic hilar nodes removal).Results. The average duration of the operation and the volume of blood loss did not differ in both groups. The incidence of early postoperative surgical complications was lower in the spleen-preserved group. Splenectomy was associated with more severe complications of class 4 and 5 according to the Clavien-Dindo classification. Conclusion. Parameters of the 1- and 3-year overall survival rate did not differ in both groups. The results of the GSRS questionnaire were similar in both groups, excluding reflux-esophageal symptoms scale. The reflux scale demonstrated a statistically and clinically significant advantage of spleen preservation.

scholarly journals Factors influencing the postoperative long-term results of the patients with gastric cancer spreading into the subserosal layer.

1990 ◽  
Vol 23 (8) ◽  
pp. 2039-2044 ◽  
Author(s):  
Hiroshi Habu ◽  
Masashi Kono ◽  
Masao Tani ◽  
Toru Honda ◽  
Fumio Kondo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Long Term Results ◽  
Factors Influencing

Long-Term Results After Intraoperative Radiation Therapy for Gastric Cancer

2008 ◽  
Vol 70 (3) ◽  
pp. 715-721 ◽  
Author(s):  
Oliver Drognitz ◽  
Karl Henne ◽  
Christian Weissenberger ◽  
Gregor Bruggmoser ◽  
Heike Göbel ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Radiation Therapy ◽  
Long Term Results ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation
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