Vacuum cleaners and dust extractors providing equipment protection level Dc for the collection of combustible dusts � Particular requirements

2019 ◽  
Keyword(s):  
Protection Level

scholarly journals FRI0458 EFFICACY AND SAFETY OF PCV13 VACCINATION IN JIA PATIENTS WITH SYSTEMIC MANIFESTATIONS ON TOCILIZUMAB AND CANAKINUMAB TREATMENT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 826.1-827
Author(s):  
D. Vankova ◽  
E. Alexeeva ◽  
T. Dvoryakovskaya ◽  
K. Isaeva ◽  
A. Chomakhidze ◽  
...  
Keyword(s):  
Respiratory Infections ◽  
Clinical Effectiveness ◽  
Immunosuppressive Drugs ◽  
Acute Stage ◽  
Acute Respiratory Infections ◽  
Efficacy And Safety ◽  
Vaccine Response ◽  
Protection Level ◽  
Acute Group ◽  
Increased Risk

Background:The need for continuous use of immunosuppressive drugs leads to increased risk of developing infectious diseases in children with juvenile idiopathic arthritis with systemic manifestation (sJIA). Questions about choosing the optimal vaccination time and the effect of different classes of therapy on vaccination effectiveness are still open.Objectives:To study clinical and laboratory effectiveness of PCV13-vaccination in children with sJIA on tocilizumab (TOC) and canakinumab (CAN) treatment depending on disease activity stage.Methods:Prospective cohort study included 2 groups of sJIA patients: in stable remission (Remission group, n=53) receiving CAN (n=10) or TOC (n=43) treatment, and in acute stage of disease (Acute group, n=25) which started to received CAN (n=7) or TOC (n=18) either before vaccination (Acute Treated Before subgroup, n=17) or after vaccination (Acute Treated After subgroup, n=8). 0.5 ml of the 13-valent PCV was administered once subcutaneously. Efficacy was evaluated by achieving of protection level of anti-pneumococcal antibodies after 4 weeks and by clinical indicators after 6 month follow-up: frequency of acute respiratory infections, frequency of antibiotics treatment courses, frequency of temporary withdrawal of biologics treatment due to severe infections. Frequency of events were counted per patients-years.Results:Four weeks after vaccination, protection level of anti-pneumococcal antibodies was achieved by for 36 (67.9%) patients in Remission group, 16 (64%) patients in Acute group (intergroup p=0.932), and in 8 (47.06%) patients in Acute Treated Before subgroup and in 8 (100%) patients in Acute Treated After subgroup (intersubgroup p=0.022). PCV13 have shown high clinical effectiveness in both Remission group and Acute group. Reducing of acute respiratory infections frequency was as follows: from 4.57 to 2.15 episodes per patient-year in Remission group (p<0.001) and from 4.32 to 1.28 per patient-year in Acute group (p<0.001).Duration of antibiotics treatment reduced from 2.31 to 0.81 weeks per 1 patient-year in Remission group (p<0.001) from 1.97 to 0.74 in Acute group (p<0.001). Among patients who were previously treated with biologics, frequency of therapy withdrawal reduced from 4.34 to 2.42 per patient-year in Remission group (p<0.001) and from 3.53 to 1.18 in Acute Treated Before subgroup (p=0.002). The incidence of reactions to vaccination of PCV13 (local hyperemia, pain, subfebrile temperature) was similar in groups (22 (41.5%) for Remission group and 7 (28%) for Acute group, p= 0.319).Conclusion:Vaccination with the 13-valent PCV has demonstrated high clinical efficacy and safety in children with sJIA both in the acute stage of the disease and during remission. Vaccination of patients in acute stage of sJIA before treatment has advantages over vaccination during remission or after prolonged immunosuppressive therapy in terms of achieving an adequate vaccine response.Disclosure of Interests:Dariya Vankova: None declared, Ekaterina Alexeeva Grant/research support from: Roche, Pfizer, Centocor, Novartis, Speakers bureau: Roche, Novartis, Pfizer., Tatyana Dvoryakovskaya: None declared, Ksenia Isaeva: None declared, Aleksandra Chomakhidze: None declared, Rina Denisova: None declared, Anna Mamutova: None declared, Anna Fetisova: None declared, Marina Gautier: None declared, Elizaveta Krekhova: None declared, Meyri Shingarova: None declared, Ivan Kriulin: None declared, Anastasiya Kontorovich: None declared, Olga Galkina: None declared, Tatyana Radygina: None declared, Irina Zubkova: None declared, Natalia Tkachenko: None declared, Yanina Orlova: None declared, Mariya Kurdup: None declared, Anna Ismailova: None declared, Alina Alshevskaya: None declared, Andrey Moskalev: None declared, Olga Lomakina: None declared

scholarly journals Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues

2021 ◽  
Vol 89 (2) ◽  
pp. 22
Author(s):  
Mariia Mishchenko ◽  
Sergiy Shtrygol’ ◽  
Andrii Lozynskyi ◽  
Semen Khomyak ◽  
Volodymyr Novikov ◽  
...  
Keyword(s):  
Drug Design ◽  
Anticonvulsant Activity ◽  
Inflammatory Activity ◽  
Significant Protection ◽  
Protection Level ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Target Agent

Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the contemporary search and design of novel anticonvulsants. In the present paper, evaluation of the anticonvulsant activity of the potential NSAID dual COX-2/5-LOX inhibitor darbufelone methanesulfonate using an scPTZ model in mice in dose 100 mg/kg is reported. Darbufelone possesses anticonvulsant properties in the scPTZ model and presents interest for in-depth studies as a possible anticonvulsant multi-target agent with anti-inflammatory activity. The series of 4-thiazolidinone derivatives have been synthesized following the analogue-based drug design and hybrid-pharmacophore approach using a darbufelone matrix. The synthesized derivatives showed a significant protection level for animals in the scPTZ model and are promising compounds for the design of potential anticonvulsants with satisfactory drug-like parameters.

Sacrificial Protection Efficiency Calculations Based on the Results of Stochastically Simulating the Parameters

2021 ◽  
Vol 410 ◽  
pp. 566-571
Author(s):  
Svetlana S. Vinogradova ◽  
Ramilya F. Tazieva ◽  
Anna N. Akhmetova
Keyword(s):  
Operating Conditions ◽  
Oil Refining ◽  
Environmental Aspects ◽  
Protection Level ◽  
Protection Efficiency ◽  
Internal Surfaces ◽  
Protection Systems ◽  
Active Protection ◽  
Refining Processes ◽  
Sacrificial Protection

Unique corrosion conditions in oil refining processes lead to the necessity of using passive and active protection systems, aimed at preventing from damages and ensuring the correct operating conditions of machines. To prevent from the development of corrosion processes on the internal surfaces of horizontal settlers, sacrificial protection is used. Before installing such a protection, they usually calculate the number of protectors to be installed in parallel. Some inputs are stochastic by their nature, which should be considered in assessing the risk of non-achieving the required protection level. The probabilistic model proposed to calculate the parameters of sacrificial tank protection that allows performing an exploratory design based on considering various environmental aspects to decide on the efficiency of sacrificial protection and to assess the achievement of the required protection level.

A new technique for SBAS availability improvement

2012 ◽  
Vol 4 (2) ◽  
pp. 217-221 ◽  
Author(s):  
Boriana Vassileva ◽  
Boris Vassilev
Keyword(s):  
Performance Indicators ◽  
Key Performance Indicators ◽  
New Technique ◽  
Worst Case ◽  
Protection Level ◽  
A New Technique

To protect a worst-case user, Satellite-Based Augmentation System (SBAS) transmits inflated integrity information for protection level computation. In this work, a novel user-based technique for autonomous protection level computation is proposed. Its quality is examined over Key Performance Indicators tests for integrity and availability using real European Geostationary Navigation Overlay Service (EGNOS) data. The accomplished experiments confirm that this technique allows significant availability improvement without breaches of the integrity.

scholarly journals About Requirements to Protection of Equipment from Explosion during Gas-Rescuing Work

10.12737/1576 ◽  
2013 ◽  
Vol 2 (5) ◽  
pp. 31-34
Author(s):  
Богач ◽  
V. Bogach ◽  
Никулин ◽  
V. Nikulin ◽  
Потапкин ◽  
...  
Keyword(s):  
Analytical Control ◽  
Control Data ◽  
Protection Level ◽  
Class Definition ◽  
Explosion Protection ◽  
Accident Conditions

The problem of explosive zones’ class definition during gas-rescuing work, as well as requirements related to applied equipment explosion protection have been considered in this paper. It is established that explosive zones in accident conditions belong to class 0 or 1. In the absence of data on an accident source and explosive substances’ leakage nature it is necessary to accept 0 class of an explosive zone and apply the equipment conforming to requirements of special explosion protection during gas-rescuing work. Liquidation of accident consequences after elimination of continuous leak sources can be made with use of explosionproof equipment according to 1 level. The equipment of increased explosion reliability isn´t applied during gas-rescuing work in conditions of explosive mixes formation. It is recommended to accept 2 class related to zones of placement of gas-rescuing works’ command point and gas-rescuing base (inside these zones’ limits the equipment of increased explosion reliability (2Ех) or with IP 54 cover protection level should be used) in case of their location at a distance less than 5 m from external borders of 1 class zone. The recommended sizes related to explosive zones of various classes have been specified subject to existence or absence of gas-analytical control data related to a content of explosive vapors and gases in the atmosphere.

scholarly journals Audio steganography based on least significant bits algorithm with 4D grid multi-wing hyper-chaotic system

2022 ◽  
Vol 12 (1) ◽  
pp. 320
Author(s):  
Hussein Abdulameer Abdulkadhim ◽  
Jinan Nsaif Shehab
Keyword(s):  
Mean Square Error ◽  
Chaotic System ◽  
Signal To Noise Ratio ◽  
Secret Message ◽  
Security Level ◽  
Mean Square ◽  
Signal To Noise ◽  
Protection Level ◽  
Voice Message ◽  
Least Significant Bits

Although variety in hiding methods used to protect data and information transmitted via channels but still need more robustness and difficulty to improve protection level of the secret messages from hacking or attacking. Moreover, hiding several medias in one media to reduce the transmission time and band of channel is the important task and define as a gain channel. This calls to find other ways to be more complexity in detecting the secret message. Therefore, this paper proposes cryptography/steganography method to hide an audio/voice message (secret message) in two different cover medias: audio and video. This method is use least significant bits (LSB) algorithm combined with 4D grid multi-wing hyper-chaotic (GMWH) system. Shuffling of an audio using key generated by GMWH system and then hiding message using LSB algorithm will provide more difficulty of extracting the original audio by hackers or attackers. According to analyses of obtained results in the receiver using peak signal-to-noise ratio (PSNR)/mean square error (MSE) and sensitivity of encryption key, the proposed method has more security level and robustness. Finally, this work will provide extra security to the mixture base of crypto-steganographic methods.

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