Traditional Chinese medicine. Panax notoginseng seeds and seedlings

2017 ◽  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Panax Notoginseng

scholarly journals High-Sensitivity Determination of Nutrient Elements in Panax notoginseng by Laser-induced Breakdown Spectroscopy and Chemometric Methods

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1525 ◽  
Author(s):  
Tingting Shen ◽  
Weijiao Li ◽  
Xi Zhang ◽  
Wenwen Kong ◽  
Fei Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Least Squares ◽  
Panax Notoginseng ◽  
High Accuracy ◽  
Laser Induced Breakdown Spectroscopy ◽  
Quantitative Detection ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

High-accuracy and fast detection of nutritive elements in traditional Chinese medicine Panax notoginseng (PN) is beneficial for providing useful assessment of the healthy alimentation and pharmaceutical value of PN herbs. Laser-induced breakdown spectroscopy (LIBS) was applied for high-accuracy and fast quantitative detection of six nutritive elements in PN samples from eight producing areas. More than 20,000 LIBS spectral variables were obtained to show elemental differences in PN samples. Univariate and multivariate calibrations were used to analyze the quantitative relationship between spectral variables and elements. Multivariate calibration based on full spectra and selected variables by the least absolute shrinkage and selection operator (Lasso) weights was used to compare the prediction ability of the partial least-squares regression (PLS), least-squares support vector machines (LS-SVM), and Lasso models. More than 90 emission lines for elements in PN were found and located. Univariate analysis was negatively interfered by matrix effects. For potassium, calcium, magnesium, zinc, and boron, LS-SVM models based on the selected variables obtained the best prediction performance with Rp values of 0.9546, 0.9176, 0.9412, 0.9665, and 0.9569 and root mean squared error of prediction (RMSEP) of 0.7704 mg/g, 0.0712 mg/g, 0.1000 mg/g, 0.0012 mg/g, and 0.0008 mg/g, respectively. For iron, the Lasso model based on full spectra obtained the best result with an Rp value of 0.9348 and RMSEP of 0.0726 mg/g. The results indicated that the LIBS technique coupled with proper multivariate chemometrics could be an accurate and fast method in the determination of PN nutritive elements for traditional Chinese medicine management and pharmaceutical analysis.

scholarly journals Efficacy and Mechanism of Panax Notoginseng in the Secondary Prevention for Stroke Patients with "Antiplatelet Drug Resistance"

2021 ◽  
Author(s):  
Jie Chen ◽  
Hui Wang ◽  
Jie Yuan ◽  
Bing Xiao ◽  
Bo Lu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Secondary Prevention ◽  
Panax Notoginseng ◽  
Aspirin Resistance ◽  
Antiplatelet Drugs ◽  
Control Group ◽  
Cerebral Stroke ◽  
Enteric Coated ◽  
Experimental Group

Abstract Background Cerebral stroke is common and associated with high rates of mortality, disability, and recurrence while the chance of complete recovery is low. It adversely affects human physical and mental health and represents the leading cause of death in China. Aspirin is the cornerstone of secondary prevention of cerebral stroke. However, recurrence of stroke cannot be completely prevented by regular oral administration of aspirin due to aspirin resistance, which is an independent risk factor for stroke recurrence. In this instance, several strategies have been taken, including dose incrementation, frequency increaseof drug administration, combination with other antiplatelet drugs, or replacing it with new antiplatelet drugs. However, these measures have led to several other undesirable outcomes, including gastrointestinal tract stimulation, increased risk of bleeding, higher cost, and poor patient compliance to treatment.let aggregation, but its efficacy and mechanism in the secondary prevention Numerous studies have confirmed that Panax notoginseng has the effect of anti-plateof cerebral stroke among patients with aspirin resistance have not been ascertained. Method/Design: This is a two-center, triple-blinded, randomized, controlled, and optimal efficiency trial. A total of 120 patients aged 45–65 years old with semi-resistance to antiplatelet drugs treated in the secondary prevention clinics for cerebral stroke in the Shaanxi Traditional Chinese Medicine Hospital and Xi'an Hospital of Traditional Chinese Medicine from October 2020 to June 2022 will be recruited. Patients are randomly divided into the experimental group and control group at the ratio of 1:1, with 60 cases in each group. The blood pressure, blood glucose, and blood lipid are controlled within the normal range as the basic standards of treatment. The experimental group is given aspirin enteric coated tablets 100 mg/day + Panax Notoginseng Powder (3 g/day, oral administrationafter dissolved), while the control group is given aspirin enteric coated tablets 100 mg/day + placebo (Panax Notoginseng Powder 0.03 g + malt powder/day, oral administration after dissolved). Measurements on the platelet aggregation rate, thromboxane A2 (TXA2), prostacyclin (PGI2), adenosine diphosphate (ADP), and changes of the coagulation index of the two groups are performed on the day-14 and day-30. The efficacy, mechanism, and safety of Panax notoginseng in the treatment of patients with aspirin resistance will be evaluated. The data are analyzed and the mean and confidence interval (CI) of 95% level are calculated by the SPSS 21.0 software. The intention-to-treat (ITT) analysis is used to account for the missing data or dropouts. Descriptive analyses are performed on the baseline population data. Repeated ANOVA (general linear model) is used to compare the differences ofkey indicators (platelet aggregation rate, thromboxane A2, prostacyclin, ADP) between the two groups.For the secondary indicators (coagulation function), two independent samples t-test and Wilcoxon rank-sum test are used. P < 0.05 is considered a statistically significant difference between the two groups. Conclusion This study aims is to explore the efficacy and mechanism of Panax notoginseng in the secondary prevention for stroke patients with aspirin resistance. The results will provide evidence-based practice for traditional Chinese medicine, and also shed light on how it may influence the secondary prevention of cerebral stroke. Trial registration: The trial has been registered with the Chinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx,) on 24th October 2020, with the registration number ChiCTR2000037833.

scholarly journals Sequence Characteristics of Dammarenediol Synthase in Medicinal Plant Panax notoginseng

2018 ◽  
Vol 6 (01) ◽  
pp. 16-21
Author(s):  
Li Gun
Keyword(s):  
Chinese Medicine ◽  
Secondary Structure ◽  
Traditional Chinese Medicine ◽  
Medicinal Plant ◽  
Tertiary Structure ◽  
Panax Notoginseng ◽  
Transmembrane Region ◽  
Medicinal Properties ◽  
Dammarenediol Synthase ◽  
Sequence Characteristics

Panax notoginseng is a commonly used herb in Traditional Chinese Medicine. It is a traditional herb plant of for manufacturing compound Danshen dripping pills, Yunnanbaiyao, et al. Dammarenediol synthase is one of its important ingredients. Some sequence characteristics, such as theoretical isoelectric point, hydrophobicity, molecular properties, transmembrane region, secondary structure and tertiary structure, of dammarenediol synthase in Panax notoginseng are studied in this paper. All results of the study would be benefit for further study on the medicinal properties of Panax notoginseng.

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