Concrete aggregates from natural sources

1954 ◽  
Keyword(s):  
Natural Sources ◽  
Concrete Aggregates

Green Concrete made with Recycled Concrete Aggregates: Fresh and Hardened Properties

2018 ◽  
Author(s):  
Driton R. Kryeziu ◽  
Armend Muja ◽  
Fisnik Kadiu ◽  
Visar Krelani ◽  
Besian Sinani ◽  
...  
Keyword(s):  
Recycled Concrete ◽  
Green Concrete ◽  
Concrete Aggregates ◽  
Recycled Concrete Aggregates ◽  
Hardened Properties

Design, 22-step synthesis, and evaluation of highly potent D-ring modified and linker-equipped analogs of spongistatin 1

2018 ◽  
Author(s):  
James Leighton ◽  
Linda M. Suen ◽  
Makeda A. Tekle-Smith ◽  
Kevin S. Williamson ◽  
Joshua R. Infantine ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Functional Group ◽  
Human Cancer ◽  
Natural Sources ◽  
Spongistatin 1 ◽  
Human Cancer Cell Lines ◽  
Drug Conjugates ◽  
Attractive Candidate ◽  
Complex Fragment ◽  
Antibody Drug

With an average GI50 value against the NCI panel of 60 human cancer cell lines of 0.12 nM, spongistatin 1 is among the most potent anti-proliferative agents ever discovered rendering it an attractive candidate for development as a payload for antibody-drug conjugates and other targeted delivery approaches. It is unavailable from natural sources and its size and complex stereostructure render chemical synthesis highly time- and resource-intensive, however, and its development requires more efficient and step-economical synthetic access. Using novel and uniquely enabling direct complex fragment coupling alkallyl- and crotylsilylation reactions, we have developed a 22-step synthesis of a rationally designed D-ring modified analog of spongistatin 1 that is equipotent with the natural product, and have used that synthesis to establish that the C(15) acetate may be replaced with a linker functional group-bearing ester with only minimal reductions in potency.<br><div><br></div>

TECHNICAL SOLUTIONS TO IMPROVE PERFORMANCE OF THE RECYCLED CEMENT CONCRETE AGGREGATES FOR DURABLE ROAD PAVEMENTS

2013 ◽  
Vol 12 (3) ◽  
pp. 595-602 ◽  
Author(s):  
Nicolae Taranu ◽  
Marius Muscalu ◽  
Radu Andrei ◽  
Irina Lungu ◽  
Mihai Budescu ◽  
...  
Keyword(s):  
Cement Concrete ◽  
Improve Performance ◽  
Concrete Aggregates ◽  
Technical Solutions
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