scholarly journals Gastrointestinal perforation: relation to corticosteroid use and COPD – a case report

2016 ◽  
Vol 6 (4) ◽  
pp. 32129
Author(s):  
Michael H.K. Nguyen ◽  
Krista M. Isaac ◽  
Rebecca Dougherty
Keyword(s):  
Case Report ◽  
Gastrointestinal Perforation

scholarly journals Cecal Perforation in a COVID-19 Patient Treated with Tocilizumab: A Case Report

2021 ◽  
pp. 1-3
Author(s):  
Victor Dominguez Prieto ◽  
Victor Dominguez Prieto ◽  
Cecilia Meliga ◽  
Sara Rosenstone ◽  
Siyuan Qian Zhang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Immune Response ◽  
Case Report ◽  
Treatment Option ◽  
Interleukin 6 ◽  
Antiviral Drugs ◽  
Gastrointestinal Perforation ◽  
Lung Damage ◽  
Cecal Perforation ◽  
Interleukin 6 Receptor

Tocilizumab is a monoclonal antibody against the interleukin-6 receptor. Gastrointestinal perforation has been associated with Tocilizumab treatment. In the absence of specific antiviral drugs, Tocilizumab is currently being used as a treatment option in patients with severe COVID-19 pneumonia. This is being based on the implication of interleukin-6 in the aberrant host immune response that characterizes the disease and initiates patients' lung damage. Herein we present the case of a cecal perforation in a patient treated with Tocilizumab for COVID-19. In such context, we expect that there may be an increase in the incidence of gastrointestinal perforation related to Tocilizumab.

Gastrointestinal perforation following dabrafenib and trametinib administration in non-small cell lung carcinoma with BRAF V600E mutation: a case report and literature review

2021 ◽  
Author(s):  
Yuri Shimada ◽  
Yuki Sato ◽  
Ryo Tachikawa ◽  
Shigeo Hara ◽  
Keisuke Tomii
Keyword(s):  
Lung Cancer ◽  
Case Report ◽  
Small Cell Lung Cancer ◽  
Intestinal Perforation ◽  
Small Cell ◽  
Braf V600e Mutation ◽  
Gastrointestinal Perforation ◽  
Braf V600e ◽  
Small Cell Lung ◽  
Small Intestinal

Abstract Gastrointestinal perforation related to mitogen-activated protein kinase kinase (MEK) inhibitors has been reported previously; however, there has been no case report of such a condition in patients with non-small cell lung cancer (NSCLC). Herein, we report a case of small intestinal perforation secondary to dabrafenib and trametinib administration, but not related to tumor regression. A 62-year-old man with non-small cell lung cancer harboring BRAF V600E mutation was treated with dabrafenib and trametinib. Four months after the initiation of treatment, a small intestinal perforation was diagnosed. Dabrafenib and trametinib rechallenge was performed after gastrointestinal perforation. The patient responded well to therapy and did not experience recurrence of gastrointestinal perforation. To the best of our knowledge, this is the first report of gastrointestinal perforation in a patient with NSCLC treated with a MEK inhibitor. The mechanism and risk factors of trametinib-induced perforation are currently unknown. Physicians should be aware of such severe gastrointestinal side effects of trametinib.

scholarly journals Surgical management of gastrointestinal perforation by ingested chicken bone: A case report

2018 ◽  
Vol 4 (4) ◽  
Author(s):  
Hanzhang Dong ◽  
Xuhui Chen ◽  
Yanfei Jiang ◽  
YHao Chen ◽  
Mingyi Wu ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Management ◽  
Gastrointestinal Perforation ◽  
Chicken Bone

GASTROINTESTINAL LESIONS IN ACUTE BULBAR POLIOMYELITIS

PEDIATRICS ◽  
1951 ◽  
Vol 7 (3) ◽  
pp. 415-421
Author(s):  
CHARLES D. COOK ◽  
JOHN R. HARTMANN ◽  
STANLEY J. SARNOFF ◽  
WILLIAM BERENBERG
Keyword(s):  
Case Report ◽  
Gastrointestinal Perforation ◽  
Blood Transfusions ◽  
Gastrointestinal Complications ◽  
Detailed Case ◽  
Intestinal Hemorrhage ◽  
Gastrointestinal Lesions ◽  
The One ◽  
Detailed Case Report

Five patients with severe bulbar poliomyelitis complicated by gastrointestinal perforation and/or hemorrhage are presented. A detailed case report is given in the one patient who recovered. The electrophrenic respirator was instrumental in maintaining this patient's respiration and massive blood transfusions in preventing shock from intestinal hemorrhage. The gastrointestinal complications of bulbar poliomyelitis appear to be more frequent than previously realized. A relationship between midbrain damage and gastrointestinal lesions, as emphasized by Cushing, occurring during the course of acute bulbar poliomyelitis, is postulated.

scholarly journals Granulomatosis with Polyangiitis Complicated with Gastrointestinal Perforation: A Case Report and Review of Literature

2017 ◽  
Vol 40 (5) ◽  
pp. 382-386 ◽  
Author(s):  
Takao KIBOSHI ◽  
Kentaro ISODA ◽  
Koichi FURUKAWA ◽  
Tomoyuki WAKAHARA ◽  
Kenichiro OTANI ◽  
...  
Keyword(s):  
Case Report ◽  
Granulomatosis With Polyangiitis ◽  
Gastrointestinal Perforation ◽  
Review Of Literature
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