scholarly journals Effects of the 5-HT2A Antagonist Sarpogrelate on Walking Ability in Patients with Intermittent Claudication as Measured Using the Walking Impairment Questionnaire

2008 ◽  
Vol 1 (2) ◽  
pp. 102-110 ◽  
Author(s):  
Hiroshi Matsuo ◽  
Hiroshi Shigematsu
Keyword(s):  
Intermittent Claudication ◽  
Walking Ability

scholarly journals Motivating Structured walking Activity in people with Intermittent Claudication (MOSAIC): protocol for a randomised controlled trial of a physiotherapist-led, behavioural change intervention versus usual care in adults with intermittent claudication

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030002 ◽  
Author(s):  
Lindsay Bearne ◽  
Melissa Galea Holmes ◽  
Julie Bieles ◽  
Saskia Eddy ◽  
Graham Fisher ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Usual Care ◽  
Intermittent Claudication ◽  
Controlled Trial ◽  
Behavioural Change ◽  
Walking Distance ◽  
Walking Ability ◽  
Walking Activity ◽  
Walking Exercise ◽  
Randomised Controlled

IntroductionWalking exercise is a recommended but underused treatment for intermittent claudication caused by peripheral arterial disease (PAD). Addressing the factors that influence walking exercise may increase patient uptake of and adherence to recommended walking. The primary aim of this randomised controlled trial (RCT) is to evaluate the efficacy of a physiotherapist-led behavioural change intervention on walking ability in adults with intermittent claudication (MOtivating Structured walking Activity in people with Intermittent Claudication (MOSAIC)) in comparison with usual care.Methods and analysisThe MOSAIC trial is a two-arm, parallel-group, single-blind RCT. 192 adults will be recruited from six National Health Service Hospital Trusts. Inclusion criteria are: aged ≥50 years, PAD (Ankle Brachial Pressure Index ≤0.90, radiographic evidence or clinician report) and intermittent claudication (San Diego Claudication Questionnaire), being able and willing to participate and provide informed consent. The primary outcome is walking ability (6 min walking distance) at 3 months. Outcomes will be obtained at baseline, 3 and 6 months by an assessor blind to group allocation. Participants will be individually randomised (n=96/group, stratified by centre) to receive either MOSAIC or usual care by an independent randomisation service. Estimates of treatment effects will use an intention-to-treat framework implemented using multiple regression adjusted for baseline values and centre.Ethics and disseminationThis trial has full ethical approval (London—Bloomsbury Research Ethics Committee (17/LO/0568)). It will be disseminated via patient forums, peer-reviewed publications and conference presentations.Trial registration numberISRCTN14501418

Co-variation between walking ability and circulatory alterations in patients with intermittent claudication

1992 ◽  
Vol 6 (6) ◽  
pp. 642-646 ◽  
Author(s):  
Berndt Arfvidsson ◽  
Ake Wennmalm ◽  
Johan Gelin ◽  
Ann-Gret Dahllöf ◽  
Birgitta Hällgren ◽  
...  
Keyword(s):  
Intermittent Claudication ◽  
Walking Ability

387 EFFECT OF RAMIPRIL THERAPY ON WALKING ABILITY AND QUALITY OF LIFE IN PATIENTS WITH INTERMITTENT CLAUDICATION

2012 ◽  
Vol 30 ◽  
pp. e114
Author(s):  
Anna Ahimastos ◽  
Philip Walker ◽  
Christopher Askew ◽  
Anthony Leicht ◽  
Elise Pappas ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Intermittent Claudication ◽  
Walking Ability

scholarly journals Assessment of Walking Ability in Patients with Intermittent Claudication Using a Smartphone Accelerometer

2021 ◽  
Vol 4 (2) ◽  
pp. 35
Author(s):  
Mark Greveling ◽  
Maaike De Bondt ◽  
Feike Weijzen ◽  
Robert Geelkerken ◽  
Mark Vlutters ◽  
...  
Keyword(s):  
Intermittent Claudication ◽  
Walking Ability

Walking ability and ankle systolic pressures: Observations in patients with intermittent claudication in a short-term walking exercise program

1989 ◽  
Vol 10 (6) ◽  
pp. 0642-0649 ◽  
Author(s):  
Stefan A. Carter ◽  
Eugene R. Hamel ◽  
Judith M. Paterson ◽  
Christopher J. Snow ◽  
David Mymin
Keyword(s):  
Intermittent Claudication ◽  
Exercise Program ◽  
Walking Ability ◽  
Short Term ◽  
Walking Exercise

scholarly journals Impairment of microcirculation and energy metabolism in intermittent claudication: beneficial effects of exercise training

2016 ◽  
Vol 72 (3) ◽  
Author(s):  
Eugenio Laurenzano ◽  
Lucrezia Spadera ◽  
Mario De Laurentis ◽  
Gregorio Brevetti
Keyword(s):  
Skeletal Muscle ◽  
Energy Metabolism ◽  
Exercise Training ◽  
Intermittent Claudication ◽  
Large Body ◽  
Arterial Disease ◽  
Walking Ability ◽  
Beneficial Effects ◽  
Relevant Role ◽  
Peripheral Arterial

Although in peripheral arterial disease (PAD) the primary determinant of inadequate blood supply to the affected limb during exercise is a flow-limiting lesion of a conduit artery, there is a large body of evidence that impairment of microcirculation and skeletal muscle energy metabolism play a relevant role in the reduced working ability of affected individuals. This review was conceived to cast some light on this topic, paying special attention to the functional benefits of exercise training (ET) in the treatment of claudicant patients. In PAD, the ischemia induced by maximal exercise increases oxidative stress, inflammation and endothelial dysfunction. Perturbation of the endothelial homeostasis results in increased adhesiveness of leukocytes and platelets, and in reduced vasodilator capability. These events, expression of the interplay between inflammation and endothelium, provoke an obstacle in the microcirculation with a reduction in the nutritive blood flow, leading to acidosis and impaired energy metabolism in skeletal muscle, with consequent reduced exercise tolerance. ET counteracts these effects by improving walking ability and quality of life in patients with intermittent claudication, thus representing the gold standard in the treatment of PAD.

Treadmill versus Shuttle Walk Tests of Walking Ability in Intermittent Claudication

2004 ◽  
Vol 36 (11) ◽  
pp. 1835-1840 ◽  
Author(s):  
IRENA ZWIERSKA ◽  
SHAH NAWAZ ◽  
RICHARD D. WALKER ◽  
RICHARD F. M. WOOD ◽  
A GRAHAM POCKLEY ◽  
...  
Keyword(s):  
Intermittent Claudication ◽  
Walking Ability ◽  
Walk Tests

Vascular Reactivity Is Impaired and Associated With Walking Ability in Patients With Intermittent Claudication

Angiology ◽  
2014 ◽  
Vol 66 (7) ◽  
pp. 680-686 ◽  
Author(s):  
Rita de Cassia Gengo e Silva ◽  
Nelson Wolosker ◽  
Juan Carlos Yugar-Toledo ◽  
Fernanda Marciano Consolim-Colombo
Keyword(s):  
Intermittent Claudication ◽  
Vascular Reactivity ◽  
Walking Ability
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