scholarly journals Nasal Cavity Metastasis From Colorectal Cancer Represents End-Stage Disease and Should Be Palliated

2020 ◽  
Vol 36 (2) ◽  
pp. 119-121
Author(s):  
Stephen Hwang ◽  
Dedrick Kok Hong Chan ◽  
Fredrik Petersson ◽  
Ker-Kan Tan
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Nasal Cavity ◽  
Metastatic Disease ◽  
Previous History ◽  
Nasal Sinus ◽  
Stage Disease ◽  
History Of ◽  
End Stage ◽  
High Index Of Suspicion

Nasal metastases from colorectal cancer is rare. The presentation of nasal metastases is often very similar to primary nasal sinus adenocarcinoma. A high index of suspicion is required, especially in patients who have had a previous history of colorectal carcinoma. Histology is ultimately required for diagnosis. We describe 2 cases of nasal metastases from colorectal carcinoma, and discuss the presentation, diagnosis and management of the case. Such metastatic disease ultimately represents end-stage malignancy, and patients should be palliated.

scholarly journals Atypical case of mucous membrane pemphigoid in a 26-year-old man

2018 ◽  
pp. bcr-2018-225872
Author(s):  
Deepak Sambhara ◽  
Ji Hyae Lee ◽  
Seth M Pantanelli
Keyword(s):  
Mucous Membrane ◽  
Previous History ◽  
Immunohistochemical Analysis ◽  
Mucous Membrane Pemphigoid ◽  
Epithelial Basement Membrane ◽  
The Face ◽  
History Of ◽  
The One ◽  
The Right ◽  
High Index Of Suspicion

A 26-year-old Caucasian man with no previous history of chemical injury presenting with an inability to open his right eye was investigated for mucous membrane pemphigoid and treated. Examination was notable for symblepharon of the right eye and impetigo-like lesions on the face and neck. A biopsy with immunohistochemical analysis was significant for linear deposits of C3 and immunoglobulin G at the level of the epithelial basement membrane, confirming the diagnosis of mucous membrane pemphigoid. Although mucous membrane pemphigoid classically presents bilaterally in women in the sixth and seventh decades of life, our patient was a young man with unilateral cicatrising conjunctivitis who may have been easily misdiagnosed without a high index of suspicion. A biopsy is required in cases of cicatrising conjunctivitis so that even atypical cases such as the one presented herein can be appropriately managed.

scholarly journals Recurrent Massive Epistaxis from an Anomalous Posterior Ethmoid Artery

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Marco Giuseppe Greco ◽  
Francesco Mattioli ◽  
Maria Paola Alberici ◽  
Livio Presutti
Keyword(s):  
Surgical Treatment ◽  
Nasal Cavity ◽  
Previous History ◽  
Bleeding Management ◽  
Left Posterior ◽  
History Of ◽  
Ethmoidal Artery ◽  
To Come ◽  
And Control

A 50-year-old man, with no previous history of epistaxis, was hospitalized at our facility for left recurrent posterior epistaxis. The patient underwent surgical treatment three times and only the operator’s experience and radiological support (cranial angiography) allowed us to control the epistaxis and stop the bleeding. The difficult bleeding management and control was attributed to an abnormal course of the left posterior ethmoidal artery. When bleeding seems to come from the roof of the nasal cavity, it is important to identify the ethmoid arteries always bearing in mind the possible existence of anomalous courses.

Moderating Effect of Physical Activity in Prevention of Colorectal and Breast Cancer by Mediterranean Diet in Females of Pakistan

2021 ◽  
Vol 15 (6) ◽  
pp. 1614-1616
Author(s):  
Ubaidullah . ◽  
Huma Tahir ◽  
Liaqat Ali ◽  
Muhammad Tahir ◽  
Zarak Khan
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Colorectal Cancer ◽  
Cancer Prevention ◽  
Mediterranean Diet ◽  
Previous History ◽  
Physical Activities ◽  
Daily Routine ◽  
History Of ◽  
Dietary Plan

Objective: The aim and purpose of the study are to determine how cancer can be prevented by maintaining a good dietary plan and physical activity. To discuss the relationship between diet and cancer prevention, guidelines, and evidence-based strategies to reduce the cancer risk (Jennifer, Karen and Wendy 2016). Cancer prevention food plan should consist of all the right amounts of macronutrients and micronutrients. Dietary guidelines can be adapted to promote health and preventing diet-related chronic diseases—a population that hasa good dietary plan, less prone to the risk of cancer. Study Design:. A cross-sectional study Place and Duration:This study was conducted at Holy Family Hospital and Wapda Hospital of Rawalpindi for duration of six months i.e from June 2020 to December 2020. Methods: Research was conducted on a sample of 58 females. Patients were aged between 18-75 years. Patients’ detailed demographics age,residency and body mass index were recorded after taking informed written consent. Previous history of breast and colorectal cancer were recorded among patients. Consumption and awareness of mediterranean diet among females were assessed. Effectiveness and recommendation of this diet were also observed. Complete data was analyzed by SPSS 24.0 version. Results:Most of the patients 35 (60.34%) were aged between 18-24 years, 12 (20.7%) were between 25-34 years of age and the rest were 11 (18.97%) >35 years of age. Mean age of the patients were 28.74±10.54 years with mean BMI 24.08±9.45 kg/m2. 41(70.7%) was not aware from mediterranean diet and regular take of this diet was found in 15 (25.9%) cases. Physical activities were found among 47 (63.%) cases. Previous history of colorectal cancer was found in 4 (6.9%) cases and breast cancer was found in 26 (44.8%) cases. 42 (72.41%) patients were agree to recommend this diet after read this useful benefits. Conclusion:We concludedin this study that the use of mediterranean diet in daily routine was useful and effective in prevention of breast and colorectal cancer. It can also be prevented by physical activities in daily work. Keywords: Colorectal cancer, breast cancer, physical activity, Mediterranean diet

scholarly journals Importance of Family History of Colorectal Carcinoma In Situ Versus Invasive Colorectal Cancer: A Nationwide Cohort Study

2021 ◽  
pp. 1-6
Author(s):  
Yu Tian ◽  
Elham Kharazmi ◽  
Hermann Brenner ◽  
Xing Xu ◽  
Kristina Sundquist ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Colorectal Carcinoma ◽  
Carcinoma In Situ ◽  
Cumulative Risk ◽  
First Degree Relatives ◽  
Younger Age ◽  
Increased Risk ◽  
History Of

Background: The aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature. Patients and Methods: We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-degree relatives. Family history was defined as a dynamic (time-dependent) variable allowing for changes during the follow-up period from 1958 to 2015. Of 12,829,251 individuals with available genealogical data, 173,796 were diagnosed with CRC and 40,558 with CCIS. Results: The lifetime (0–79 years) cumulative risk of CRC in first-degree relatives of patients with CCIS was 6.5%, which represents a 1.6-fold (95% CI, 1.5–1.7; n=752) increased risk. A similarly increased lifetime cumulative risk (6.7%) was found among first-degree relatives of patients with CRC (SIR, 1.6; 95% CI, 1.6–1.7; n=6,965). An increased risk of CRC was also found in half-siblings of patients with CCIS (SIR, 1.9; 95% CI, 1.1–3.0; n=18) and also in half-siblings of patients with CRC (SIR, 1.7; 95% CI, 1.3–2.1; n=78). Moreover, the increased risk of CRC was higher for younger age at diagnosis of CCIS in the affected first-degree relative and for younger age at diagnosis of CRC in the index person. Conclusions: Results of this study show that first-degree relatives and half-siblings of patients with CCIS have an increased risk of CRC, which is comparable in magnitude to the risk of those with a family history of invasive CRC. These findings extend available evidence on familial risk of CRC and may help to refine guidelines and recommendations for CRC screening.

scholarly journals Case of Metastatic Malignant Melanoma Simulating Granuloma Annulare

2021 ◽  
Vol 5 (3) ◽  
pp. 289-292
Author(s):  
Haley Danielle Heibel ◽  
Parneet Dhaliwal ◽  
Etan Marks ◽  
Clay J. Cockerell
Keyword(s):  
Malignant Melanoma ◽  
Metastatic Melanoma ◽  
Immunohistochemical Staining ◽  
Previous History ◽  
Metastatic Malignant Melanoma ◽  
Granuloma Annulare ◽  
Diagnostic Challenge ◽  
Clinical Presentations ◽  
History Of ◽  
High Index Of Suspicion

Malignant melanoma and particularly metastatic melanoma represent a diagnostic challenge due to the wide variety of histologic patterns, resemblance to benign entities, and extensive range of clinical presentations.  A high index of suspicion for melanoma is important for accurate diagnosis, especially when there is a previous history of malignancy.  Here, we present a patient with a history of melanoma and locally metastatic melanoma, who subsequently developed a nodule on his right forearm near the site of his previous melanoma excision.  Histologically, the melanoma appeared as granuloma annulare (GA) with benign cytologic features, but was identified as metastatic melanoma using SOX-10 immunohistochemical staining.  Other malignancies, including lymphomas, leukemias, sarcomas, and cutaneous metastases of internal malignancies, have mimicked GA and interstitial granulomatous processes.  Therefore, further immunohistochemical staining should be performed to assess for metastatic disease in the setting of a histological pattern that resembles a benign granulomatous process in a patient with a history of malignancy, including malignant melanoma.

Novel Biomarker-Targeted Therapies for Metastatic Colorectal Cancer

2021 ◽  
Author(s):  
Shimoli V. Barot ◽  
Suneel D. Kamath
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Metastatic Disease ◽  
Targeted Therapies ◽  
Early Stage ◽  
Growth Factor Receptor ◽  
Precision Oncology ◽  
Dynamic Heterogeneity ◽  
Early Stage Disease ◽  
Stage Disease

AbstractColorectal cancer (CRC) is one of the most common and fatal malignancies worldwide. Screening, surgery, and adjuvant therapy have proved efficacious in improving outcomes for early-stage disease. Despite decades of research efforts, cytotoxic chemotherapy has been the mainstay of treatment for metastatic disease and the prognosis remains unsatisfactory. Compelling evidence suggests that a fundamental reason for the limited success is the cancer's inherent dynamic heterogeneity, which is more predominant in late-stage disease. As our understanding of this molecular blueprint of CRC has evolved, a new avenue of targeted therapies has emerged. Beginning with epidermal growth factor receptor and vascular endothelial growth factor inhibitors, numerous targeted agents have been developed and investigated in large, multicenter, prospective clinical trials. Testing for mutations in RAS (KRAS and NRAS), BRAF, and HER2 and for mismatch repair/microsatellite instability and NTRK fusions has now been incorporated in the management guidelines, with additional biomarkers rapidly surfacing. As we enter the latest paradigm of precision oncology in CRC, this article will provide an overview of the different molecular subsets of CRC and the current biomarker-targeted therapies in the management of metastatic disease.

scholarly journals Breast Cancer Profile among Patients with a History of Chemoprevention

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Freya R. Schnabel ◽  
Sarah Pivo ◽  
Jennifer Chun ◽  
Shira Schwartz ◽  
Ana Paula Refinetti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Previous History ◽  
Prevention Strategies ◽  
Stage Disease ◽  
Prior Use ◽  
History Of ◽  
Timing Of Initiation

Purpose. This study identifies women with breast cancer who utilized chemoprevention agents prior to diagnosis and describes their patterns of disease.Methods. Our database was queried retrospectively for patients with breast cancer who reported prior use of chemoprevention. Patients were divided into primary (no history of breast cancer) and secondary (previous history of breast cancer) groups and compared to patients who never took chemoprevention.Results. 135 (6%) of 2430 women used chemoprevention. In the primary chemoprevention group (n= 18, 1%), 39% had completed >5 years of treatment, and fully 50% were on treatment at time of diagnosis. These patients were overwhelmingly diagnosed with ER/PR positive cancers (88%/65%) and were diagnosed with equal percentages (44%) of IDC and DCIS. 117 (87%) used secondary chemoprevention. Patients in this group were diagnosed with earlier stage disease and had lower rates of ER/PR-positivity (73%/65%) than the nonchemoprevention group (84%/72%). In the secondary group, 24% were on chemoprevention at time of diagnosis; 73% had completed >5 years of treatment.Conclusions. The majority of patients who used primary chemoprevention had not completed treatment prior to diagnosis, suggesting that the timing of initiation and compliance to prevention strategies are important in defining the pattern of disease in these patients.

scholarly journals Thumb metastases in a patient with colorectal cancer

2007 ◽  
Vol 15 (3-4) ◽  
pp. 97-98 ◽  
Author(s):  
Ivan Nikolic ◽  
Aleksandar Patrnogic ◽  
Bratislav Stojiljkovic ◽  
Bogdan Bogdanovic ◽  
Biljana Kukic
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Disease ◽  
Proximal Phalanx ◽  
Lumbar Vertebra ◽  
Palliative Radiotherapy ◽  
Metastatic Colorectal Carcinoma ◽  
Primary Surgery ◽  
History Of ◽  
Histopathologic Analysis ◽  
Hand Radiography

Bone metastases from colorectal cancer are not common and most frequently are manifesting in late history of metastatic disease. We present a 67-old man who had first symptoms of metastatic disease manifested with edema and decreased mobility of thumb of right hand. Radiography showed complete osteolysis of proximal phalanx of thumb, which appeared 30 months after primary surgery for colorectal cancer. Histopathologic analysis of amputated thumb confirmed diagnosis of metastatic colorectal carcinoma and excluded osteolysis of other reasons. Metastatic changes in the first and second lumbar vertebra, which were treated with palliative radiotherapy, were confirmed by additional diagnostics.

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