Enabling Technologies for Medicinal Chemistry and Synthesis: I. Cannabinoids; II. Illudalic Acid; III. Microwave Chemistry

2021 ◽  
Author(s):  
Harvey Fulo
Keyword(s):  
Medicinal Chemistry ◽  
Microwave Chemistry ◽  
Enabling Technologies

Green Enabling Technologies for Competitive Synthesis of Pharmaceutical Lead Compounds

2020 ◽  
Vol 26 (44) ◽  
pp. 5700-5712
Author(s):  
Silvia Tagliapietra ◽  
Arianna Binello ◽  
Fabio Bucciol ◽  
Vladimir Trukhan ◽  
Mariachiara Colia ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Process Intensification ◽  
Flow Chemistry ◽  
Reaction Rates ◽  
Chemical Library ◽  
Production Chain ◽  
Enabling Technologies ◽  
Slow Kinetics ◽  
Drug Synthesis ◽  
Pharmaceutical Production

Combinations of different technologies are at the heart of the development and implementation of new, innovative processes and approaches for Industry 4.0 in the field of medicinal chemistry and drug discovery. Process intensification and advances in high-throughput synthetic techniques can dramatically improve reaction rates in processes for which slow kinetics represents a bottleneck. Easier access to target-based chemical library collections offers wider access to new leads for drug development. Green enabling technologies are a reliable ally for the design of environmentally friendly synthetic processes and more highly competitive pharmaceutical production. Mechanochemistry, microwaves, ultrasound and flow chemistry are mature techniques that can boast drug synthesis when properly integrated into the production chain. In this review, we selected examples from the literature of the last five years related to medicinal chemistry.

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