scholarly journals Novel 3D Ultrasound Elastography Techniques for In Vivo Breast Tumor Imaging and Nonlinear Characterization

2013 ◽  
Author(s):  
Ahmed A. Hameed Sayed
Keyword(s):  
Breast Tumor ◽  
Tumor Imaging ◽  
3D Ultrasound ◽  
Ultrasound Elastography ◽  
Nonlinear Characterization

scholarly journals Nonlinear characterization of breast cancer using multi-compression 3D ultrasound elastography in vivo

Ultrasonics ◽  
2013 ◽  
Vol 53 (5) ◽  
pp. 979-991 ◽  
Author(s):  
Ahmed Sayed ◽  
Ginger Layne ◽  
Jame Abraham ◽  
Osama Mukdadi
Keyword(s):  
Breast Cancer ◽  
3D Ultrasound ◽  
Ultrasound Elastography ◽  
Nonlinear Characterization

3D Ultrasound Elastographic Imaging and Characterization of Breast Cancer In Vivo

2012 ◽  
Author(s):  
Ahmed Sayed ◽  
Ginger Layne ◽  
Jame Abraham ◽  
Osama Mukdadi
Keyword(s):  
Breast Cancer ◽  
Soft Tissue ◽  
Dimensional Space ◽  
Strain Difference ◽  
Invasive Procedure ◽  
3D Ultrasound ◽  
Ultrasound Elastography ◽  
Surrounding Soft Tissue ◽  
Classification Parameter

Breast cancer has a high mortality rate and caused about 13.7% of all cancer types deaths in women. Mammography imaging, having a good sensitivity to cancer, is used along with biopsy in a routinely manner, to differentiate between malignant and benign masses. Biopsy is an invasive procedure, and to reduce the necessity for performing it, ultrasound elastography was proposed. Elastography is a potential imaging technique to characterize breast masses, and to differentiate malignant from benign lesions, based on imaging estimated tissue strains under compression. This can result in lowering the number of unnecessary biopsies. Using 3D elastography, lesion relative stiffness with the surrounding soft tissue is estimated at different compression levels, and used as a classification parameter to judge the malignancy of the lesion. In addition, elastography provided a means of emphasizing the strain difference of the lesion from the surrounding soft tissue, which can be used as an additional classification parameter. A pilot study on volunteered patients was performed, and results were compared with biopsy diagnosis as a reference. Initial elastography results showed good agreement with biopsy outcomes. Moreover, we constructed different strain elastograms including first principal, maximum shear and von Mises strains. Those new types of elastographic volumes incorporated the normal axial and shear strains together, which provided better distinction of the hard lesion from the soft tissue. In summary, the proposed elastographic techniques can be used as a noninvasive quantitative characterization tool for breast cancer, with the capability of visualizing and separating the masses in three dimensional space.

A selenium-containing selective histone deacetylase 6 inhibitor for targeted in vivo breast tumor imaging and therapy

2019 ◽  
Vol 7 (22) ◽  
pp. 3528-3536 ◽  
Author(s):  
Chu Tang ◽  
Yang Du ◽  
Qian Liang ◽  
Zhen Cheng ◽  
Jie Tian
Keyword(s):  
Breast Cancer ◽  
Histone Deacetylase ◽  
Treatment Efficacy ◽  
Breast Tumor ◽  
Tumor Imaging ◽  
Selective Inhibitor ◽  
Biodistribution Study ◽  
Histone Deacetylase 6 ◽  
Antitumor Effects

We have developed a HDAC6-selective inhibitor, SelSA, which can be utilized as a target for the detection and treatment of ERα(+) breast cancer and TNBC. The biodistribution study showed that SelSA can specifically target the breast tumor and display potent antitumor effects in vivo. This result will help to better improve the treatment efficacy against breast cancer.

Diagnosis of Breast Tumor Using 2D and 3D Ultrasound Images

2011 ◽  
Author(s):  
Yougun Han ◽  
Dong-Woo Kim ◽  
Boxin Zhao ◽  
H. J. Kwon
Keyword(s):  
Breast Tumor ◽  
3D Ultrasound ◽  
The Body ◽  
Ultrasound Images ◽  
Smoothing Algorithm ◽  
New Information ◽  
Gradient Based ◽  
In Vivo Diagnosis ◽  
2D And 3D

DIC and DVC algorithms combined with smoothing algorithm were applied to ultrasound B mode images to generate 2D and 3D elastograms. The DIC based elastograms have better accuracy than conventional time-gradient based elastograms, and can estimate the size and the relative elastic modulus of the inclusion with a reasonable accurately. The study shows the potential to apply DIC and DVC based elastograms to the in-vivo diagnosis of pathological tissue within the body, and to provide new information that is related to tissue structure and/or pathology.

Oxohexestrol derivatives labeled with fluorine-18. Synthesis, receptor binding and in vivo distribution of two non-steroidal estrogens as potential breast tumor imaging agents

1994 ◽  
Vol 21 (1) ◽  
pp. 25-39 ◽  
Author(s):  
Kathryn E. Bergmann ◽  
Scott W. Landvatter ◽  
Pamela G. Rocque ◽  
Kathryn E. Carlson ◽  
Michael J. Welch ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Breast Tumor ◽  
Tumor Imaging ◽  
Imaging Agents ◽  
In Vivo Distribution

Patients with fever of unknown origin (FUO): diagnosis by nuclear medicine imaging

2001 ◽  
Vol 40 (03) ◽  
pp. 59-70 ◽  
Author(s):  
W. Becker ◽  
J. Meiler
Keyword(s):  
Nuclear Medicine ◽  
Fever Of Unknown Origin ◽  
Tumor Imaging ◽  
White Blood Cells ◽  
Unknown Origin ◽  
Final Diagnosis ◽  
Recurrent Fever ◽  
Nuclear Medicine Imaging

SummaryFever of unknown origin (FUO) in immunocompetent and non neutropenic patients is defined as recurrent fever of 38,3° C or greater, lasting 2-3 weeks or longer, and undiagnosed after 1 week of appropriate evaluation. The underlying diseases of FUO are numerous and infection accounts for only 20-40% of them. The majority of FUO-patients have autoimmunity and collagen vascular disease and neoplasm, which are responsible for about 50-60% of all cases. In this respect FOU in its classical definition is clearly separated from postoperative and neutropenic fever where inflammation and infection are more common. Although methods that use in-vitro or in-vivo labeled white blood cells (WBCs) have a high diagnostic accuracy in the detection and exclusion of granulocytic pathology, they are only of limited value in FUO-patients in establishing the final diagnosis due to the low prevalence of purulent processes in this collective. WBCs are more suited in evaluation of the focus in occult sepsis. Ga-67 citrate is the only commercially available gamma emitter which images acute, chronic, granulomatous and autoimmune inflammation and also various malignant diseases. Therefore Ga-67 citrate is currently considered to be the tracer of choice in the diagnostic work-up of FUO. The number of Ga-67-scans contributing to the final diagnosis was found to be higher outside Germany than it has been reported for labeled WBCs. F-l 8-2’-deoxy-2-fluoro-D-glucose (FDG) has been used extensively for tumor imaging with PET. Inflammatory processes accumulate the tracer by similar mechanisms. First results of FDG imaging demonstrated, that FDG may be superior to other nuclear medicine imaging modalities which may be explained by the preferable tracer kinetics of the small F-l 8-FDG molecule and by a better spatial resolution of coincidence imaging in comparison to a conventional gamma camera.

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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