scholarly journals Acute and Repeated Effects of Synthetic Cannabinoid Agonism and Cannabinoid Receptor 1 Positive Allosteric Modulation

2019 ◽  
Author(s):  
Kristen R. Trexler
Keyword(s):  
Cannabinoid Receptor ◽  
Allosteric Modulation ◽  
Synthetic Cannabinoid ◽  
Cannabinoid Receptor 1

scholarly journals Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism

2020 ◽  
Author(s):  
Sergei Gavryushov ◽  
Anton Bashilov ◽  
Konstantin Cherashev-Tumanov ◽  
Nikolay Kuzmich ◽  
Tatyana Burykina ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Cannabinoid Receptor ◽  
Theoretical Models ◽  
Allosteric Modulation ◽  
Synthetic Cannabinoid ◽  
Receptor Agonists ◽  
Ligand Interactions ◽  
Synthetic Cannabinoid Receptor Agonists ◽  
Dynamics Simulations ◽  
Agonist Ligands

The manuscript of a paper entitled "Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism". The work describes computer simulations of activation of the Cannabinoid Receptor I at binding of its agonist ligands. The molecular mechanism of the receptor-ligand interactions and receptor's activation is explored. The study includes theoretical models construction, intense molecular dynamics simulations, comparison with experimentally-known data. Some conclusions allow for better understanding of G-protein-copupled receptor mechanism of transmembrane allosteric modulation.

scholarly journals Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism

2020 ◽  
Author(s):  
Sergei Gavryushov ◽  
Anton Bashilov ◽  
Konstantin Cherashev-Tumanov ◽  
Nikolay Kuzmich ◽  
Tatyana Burykina ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Cannabinoid Receptor ◽  
Theoretical Models ◽  
Allosteric Modulation ◽  
Synthetic Cannabinoid ◽  
Receptor Agonists ◽  
Ligand Interactions ◽  
Synthetic Cannabinoid Receptor Agonists ◽  
Dynamics Simulations ◽  
Agonist Ligands

The manuscript of a paper entitled "Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism". The work describes computer simulations of activation of the Cannabinoid Receptor I at binding of its agonist ligands. The molecular mechanism of the receptor-ligand interactions and receptor's activation is explored. The study includes theoretical models construction, intense molecular dynamics simulations, comparison with experimentally-known data. Some conclusions allow for better understanding of G-protein-copupled receptor mechanism of transmembrane allosteric modulation.

Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis

2020 ◽  
Vol 29 (7) ◽  
pp. 616-622 ◽  
Author(s):  
Attila Oláh ◽  
Majid Alam ◽  
Jérémy Chéret ◽  
Nikolett Gréta Kis ◽  
Zoltán Hegyi ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cannabinoid Receptor ◽  
Human Epidermis ◽  
Cannabinoid Receptor 1 ◽  
Mitochondrial Energy Metabolism
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