scholarly journals Development of improved T cell receptor beta variable gene identification technology and its application post hematopoietic stem cell transplantation

2005 ◽  
Author(s):  
Jamie Leigh Brewer
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Gene Identification ◽  
Hematopoietic Stem ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Receptor Beta

Evaluating the link between T cell receptor beta variable gene polymorphism and immune mediated adverse events during checkpoint blockade immunotherapy.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e15002-e15002 ◽  
Author(s):  
Timothy Looney ◽  
Elizabeth Linch ◽  
Geoffrey Lowman ◽  
Lauren Miller ◽  
Jianping Zheng ◽  
...  
Keyword(s):  
T Cell ◽  
Adverse Events ◽  
Gene Polymorphism ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Immune Mediated ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Receptor Beta

scholarly journals Haplotype Analysis of the TRB Locus by TCRB Repertoire Sequencing

2018 ◽  
Author(s):  
Timothy J Looney ◽  
Dzifa Y Duose ◽  
Geoffrey Lowman ◽  
Elizabeth Linch ◽  
Joud Hajjar ◽  
...  
Keyword(s):  
T Cell Receptor ◽  
Haplotype Analysis ◽  
Cell Receptor ◽  
Repetitive Nature ◽  
Repertoire Sequencing ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Tcrb Locus ◽  
Receptor Beta

AbstractPolymorphism within the T cell receptor beta variable gene (TRBV) has been implicated in autoimmune disease and immuneCrelated adverse events (IRAEs) during immunotherapy. Previous efforts to evaluate TRBV polymorphism by whole genome sequencing (WGS) have been hampered by the repetitive nature of the TCRB locus. We present a novel longCamplicon TCRB repertoire sequencing approach to evaluate TRBV polymorphism from peripheral blood, which we use to identify TRBV allele haplotypes in 81 Caucasians.

scholarly journals Effect of Triptolide on T-Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen-Induced Arthritis

2012 ◽  
Vol 295 (6) ◽  
pp. 922-927 ◽  
Author(s):  
Jixi Wang ◽  
Aibing Wang ◽  
Heqing Zeng ◽  
Lantao Liu ◽  
Wenhao Jiang ◽  
...  
Keyword(s):  
T Cell ◽  
Mrna Expression ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Collagen Induced Arthritis ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Beta Variable ◽  
Receptor Beta ◽  
Gene Mrna

Narrowing of T‐cell receptor beta variable repertoire during symptomatic herpesvirus infection in transplant patients

2009 ◽  
Vol 88 (2) ◽  
pp. 125-135 ◽  
Author(s):  
Katherine K Wynn ◽  
Tania Crough ◽  
Scott Campbell ◽  
Keith McNeil ◽  
Andrew Galbraith ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Herpesvirus Infection ◽  
Transplant Patients ◽  
T Cell Receptor Beta ◽  
Beta Variable ◽  
Receptor Beta

scholarly journals Genetic T-cell receptor diversity at 1 year following allogeneic hematopoietic stem cell transplantation

Leukemia ◽  
2019 ◽  
Vol 34 (5) ◽  
pp. 1422-1432 ◽  
Author(s):  
Stéphane Buhler ◽  
Florence Bettens ◽  
Carole Dantin ◽  
Sylvie Ferrari-Lacraz ◽  
Marc Ansari ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Hematopoietic Stem

Expression Profile and Clonality of T-Cell Receptor Beta Variable Genes in Normal Human Endometrium

2006 ◽  
Vol 55 (5) ◽  
pp. 349-359 ◽  
Author(s):  
Pouneh Dokouhaki ◽  
Rosa Moghadam ◽  
Firoozeh Akbariasbagh ◽  
Amirhassan Zarnani ◽  
Marefat Ghaffari Novin ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Expression Profile ◽  
Cell Receptor ◽  
Human Endometrium ◽  
T Cell Receptor Beta ◽  
Normal Human ◽  
Beta Variable ◽  
Receptor Beta ◽  
Variable Genes

The Human T cell Receptor Beta Variable (TRBV) Genes

2000 ◽  
Vol 17 (1) ◽  
pp. 42-54 ◽  
Author(s):  
Géraldine Folch ◽  
Marie-Paule Lefranc
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Beta Variable ◽  
Receptor Beta

Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients

Blood ◽  
2005 ◽  
Vol 105 (2) ◽  
pp. 886-893 ◽  
Author(s):  
Xiaohua Chen ◽  
Raymond Barfield ◽  
Ely Benaim ◽  
Wing Leung ◽  
James Knowles ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
T Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Hematopoietic Stem ◽  
Thymic Function ◽  
T Cell Reconstitution

Abstract The extent and rapidity with which T cells are regenerated from graft-derived precursor cells directly influences the incidence of infection and the T-cell–based graft-versus-tumor effect. Measurement of T-cell receptor excision circles (TRECs) in peripheral blood is a means of quantifying recent thymic T-cell production and has been used after transplantation in many studies to estimate thymus-dependent T-cell reconstitution. We hypothesized that the quality of thymic function before transplantation affects thymus-dependent T-cell reconstitution after transplantation. We used real-time polymerase chain reaction (PCR) to quantify signal-joint TRECs (sjTRECs) before and after transplantation. T-cell reconstitution was evaluated by T-cell receptor β (TCRβ) CDR3 size spectratyping. We tested 77 healthy sibling donors and 244 samples from 26 pediatric recipients of allogeneic hematopoietic stem cell transplantation (AHSCT). Blood from the healthy donors contained 1200 to 155 000 sjTREC copies/mL blood. Patients who had greater than 1200 copies/mL blood before transplantation showed early recovery of sjTREC numbers and TCRβ repertoire diversity. In contrast, patients who had fewer than 1200 copies/mL blood before transplantation demonstrated significantly slower restoration of thymus-dependent T cells. We conclude that the rate of reconstitution of thymus-dependent T cells is dependent on the competence of thymic function in the recipients before transplantation. Therefore, pretransplantation measurement of sjTREC may provide an important tool for predicting thymus-dependent T-cell reconstitution after transplantation.

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