scholarly journals Metallothionein isoform 3 expression in human bladder urothelium

2003 ◽  
Author(s):  
Seongmi Park
Keyword(s):  
Human Bladder ◽  
Bladder Urothelium ◽  
Metallothionein Isoform 3

306 Immunohistochemical evidence of vanilloid receptor 1 (VR1) in normal human bladder urothelium

2004 ◽  
Vol 3 (2) ◽  
pp. 79 ◽  
Author(s):  
M. Lazzeri ◽  
D. Turini ◽  
P. Beneforti ◽  
M. Spinelli ◽  
S. Malaguti ◽  
...  
Keyword(s):  
Vanilloid Receptor ◽  
Human Bladder ◽  
Bladder Urothelium ◽  
Vanilloid Receptor 1 ◽  
Normal Human ◽  
Immunohistochemical Evidence

scholarly journals WS1-4-4 Anticholinergic Drugs can Suppress Non-neuronal ATP Release from Human Bladder Urothelium(Urodynamic, Prostate and Urethra)

2008 ◽  
Vol 99 (2) ◽  
pp. 151
Author(s):  
Masaki Yoshida ◽  
Koichi Masunaga ◽  
Yoshihiro Maeda ◽  
You Satoji ◽  
Takashi Nagata ◽  
...  
Keyword(s):  
Atp Release ◽  
Anticholinergic Drugs ◽  
Human Bladder ◽  
Bladder Urothelium

989: Anticholinergic Drugs Can Suppress Non-Neuronal ATP Release from Human Bladder Urothelium

2007 ◽  
Vol 177 (4S) ◽  
pp. 327-327 ◽  
Author(s):  
Masaki Yoshida ◽  
Koichi Masunaga ◽  
Yoshihiro Maeda ◽  
You Satoji ◽  
Kenshi Matsumoto ◽  
...  
Keyword(s):  
Atp Release ◽  
Anticholinergic Drugs ◽  
Human Bladder ◽  
Bladder Urothelium

Non-neuronal cholinergic system in human bladder urothelium

Urology ◽  
2006 ◽  
Vol 67 (2) ◽  
pp. 425-430 ◽  
Author(s):  
Masaki Yoshida ◽  
Akito Inadome ◽  
Yoshihiro Maeda ◽  
You Satoji ◽  
Koichi Masunaga ◽  
...  
Keyword(s):  
Cholinergic System ◽  
Human Bladder ◽  
Bladder Urothelium

1736: P2X2 and P2X3 Receptor Expression in the Human Bladder Urothelium and Changes in Interstitial Cystitis

2004 ◽  
Vol 171 (4S) ◽  
pp. 459-459
Author(s):  
Heidi Tempest ◽  
Alistair K. Dixon ◽  
Lynda A. Sellers ◽  
William H. Turner ◽  
Douglas R. Ferguson
Keyword(s):  
Interstitial Cystitis ◽  
Receptor Expression ◽  
P2x3 Receptor ◽  
Human Bladder ◽  
Bladder Urothelium

Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment

2010 ◽  
Vol 299 (6) ◽  
pp. F1245-F1256 ◽  
Author(s):  
Marcia R. Saban ◽  
Thomas J. Sferra ◽  
Carole A. Davis ◽  
Cindy Simpson ◽  
Arielle Allen ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Inflammatory Responses ◽  
Lymphatic Vessels ◽  
Inflammatory Cells ◽  
Bladder Cancer Cell Line ◽  
Vegf Receptors ◽  
Human Bladder ◽  
Bladder Urothelium ◽  
Bladder Inflammation

Recent findings indicate that VEGF receptors and coreceptors (neuropilins; NRP) are expressed on nonendothelial cells in human bladder urothelium, in one human bladder cancer cell line (J82), and in the mouse bladder urothelium. In addition, VEGFR1, VEGFR2, NRP1, and NRP2 expressions were upregulated in animal models of chronic bladder inflammation induced by four weekly instillations of protease-activated receptors (PAR)-activating peptides or bacillus Calmette-Guérin (BCG) into the mouse bladder. Here, we used four weekly instillations of BCG as a model for chronic bladder inflammation to further investigate whether VEGF receptors and NRPs play a role in the migration of inflammatory cells and inflammation-induced lymphangiogenesis and angiogenesis. For this purpose, we used neutralizing antibodies that were engineered to specifically block the binding of VEGF to NRP (anti-NRP1B) and the binding of semaphorins to NRP (anti-NRP1A). C57BL/6 mice received intraperitoneal injections of PBS, anti-NRP1A- or anti-NRP1B-neutralizing antibodies and then were challenged chronically with intravesical PBS or BCG. At the end of chronic challenge period, a fluorescent internalizable tracer, scVEGF/Cy5.5, was administered to all mice and near-infrared fluorescence images were obtained in vivo and in real time. BCG increased the overall accumulation of scVEGF/Cy5.5 in the urinary bladder urothelium and inflammatory cells. In addition, BCG increased the density of blood and lymphatic vessels concomitantly with an upregulation of NRP2 expression in lymphatic vessels. Treatment of the mice with NRP1-neutralizing antibodies dramatically reduced scVEGF/Cy5.5 uptake, polymorphonuclear (myeloperoxidase-positive cells) and dendritic cell (CD11c-positive cells) infiltration, and decreased the overall density of BCG-induced blood and lymphatic vessels. These results implicate NRPs as critical in vivo regulators of the vascular and inflammatory responses to the intravesical administration of BCG.

P2X2 and P2X3 receptor expression in human bladder urothelium and changes in interstitial cystitis

2004 ◽  
Vol 93 (9) ◽  
pp. 1344-1348 ◽  
Author(s):  
H.V. Tempest ◽  
A.K. Dixon ◽  
W.H. Turner ◽  
S. Elneil ◽  
L.A. Sellers ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Receptor Expression ◽  
P2x3 Receptor ◽  
Human Bladder ◽  
Bladder Urothelium
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