scholarly journals Investigations of Pro- and Anti-Apoptotic Factors Affecting African Swine Fever Virus Replication and Pathogenesis

Viruses ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 241 ◽  
Author(s):  
Linda Dixon ◽  
Pedro Sánchez-Cordón ◽  
Inmaculada Galindo ◽  
Covadonga Alonso
Keyword(s):  
Virus Replication ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Factors Affecting ◽  
Apoptotic Factors

scholarly journals Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence and virulence from attenuated BeninΔDP148R

2021 ◽  
Author(s):  
Vlad Petrovan ◽  
Anusyah Rathakrishnan ◽  
Muneeb Islam ◽  
Lynnette Goatley ◽  
Katy Moffat ◽  
...  
Keyword(s):  
Virus Replication ◽  
Vaccine Development ◽  
African Swine Fever Virus ◽  
Clinical Signs ◽  
African Swine Fever ◽  
Viral Persistence ◽  
Fever Virus ◽  
Post Immunization

The limited knowledge on the role of many of the approximately 170 proteins encoded by African swine fever virus restricts progress towards vaccine development. In this study we investigated the effect of deleting combinations of different genes from a previously attenuated virus, BeninΔDP148R on: virus replication in macrophages, virus persistence and clinical signs post immunization, and induction of protection against challenge. Deletion of either EP402R or EP153R genes individually or in combination from BeninΔDP148R did not reduce virus replication in vitro. However, deletion of EP402R dramatically reduced viral persistence in vivo, whilst maintaining high levels of protection against challenge. The additional deletion of EP153R (BeninΔDP148RΔEP153RΔEP402R) further attenuated the virus and no viremia or clinical signs were observed post immunization. This was associated with decreased protection and detection of moderate levels of challenge virus in blood. Interestingly, the deletion of EP153R alone from BeninΔDP148R did not result in further virus attenuation and a slight increase in virus genome copies in blood was observed at different times post immunization when compared with BeninΔDP148R. These results show that EP402R and EP153R have a synergistic role in promoting viremia, however EP153R alone does not seem to have a major impact on virus levels in blood.

scholarly journals Efficient inhibition of African swine fever virus replication by CRISPR/Cas9 targeting of the viral p30 gene (CP204L)

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Alexandra Hübner ◽  
Bjoern Petersen ◽  
Günther M. Keil ◽  
Heiner Niemann ◽  
Thomas C. Mettenleiter ◽  
...  
Keyword(s):  
Virus Replication ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus

African swine fever virus replication events and cell nucleus: New insights and perspectives

2019 ◽  
Vol 270 ◽  
pp. 197667 ◽  
Author(s):  
Margarida Simões ◽  
Ferdinando B. Freitas ◽  
Alexandre Leitão ◽  
Carlos Martins ◽  
Fernando Ferreira
Keyword(s):  
Virus Replication ◽  
Cell Nucleus ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus

scholarly journals Redistribution of Endosomal Membranes to the African Swine Fever Virus Replication Site

Viruses ◽  
2017 ◽  
Vol 9 (6) ◽  
pp. 133 ◽  
Author(s):  
Miguel Cuesta-Geijo ◽  
Lucía Barrado-Gil ◽  
Inmaculada Galindo ◽  
Raquel Muñoz-Moreno ◽  
Covadonga Alonso
Keyword(s):  
Virus Replication ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Endosomal Membranes ◽  
Replication Site

scholarly journals No evidence of African swine fever virus replication in hard ticks

2014 ◽  
Vol 5 (5) ◽  
pp. 582-589 ◽  
Author(s):  
Helena C. de Carvalho Ferreira ◽  
Sara Tudela Zúquete ◽  
Michiel Wijnveld ◽  
Eefke Weesendorp ◽  
Frans Jongejan ◽  
...  
Keyword(s):  
Virus Replication ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Hard Ticks

scholarly journals The CD2v protein enhances African swine fever virus replication in the tick vector, Ornithodoros erraticus

Virology ◽  
2009 ◽  
Vol 393 (2) ◽  
pp. 319-328 ◽  
Author(s):  
Rebecca J. Rowlands ◽  
Margarida M. Duarte ◽  
Fernando Boinas ◽  
Geoff Hutchings ◽  
Linda K. Dixon
Keyword(s):  
Virus Replication ◽  
African Swine Fever Virus ◽  
African Swine Fever ◽  
Fever Virus ◽  
Tick Vector
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