scholarly journals Gene Regulation and Quality Control in Murine Polyomavirus Infection

Viruses ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 284 ◽  
Author(s):  
Gordon Carmichael
Keyword(s):  
Quality Control ◽  
Gene Regulation ◽  
Murine Polyomavirus

NMD-Based Gene Regulation—A Strategy for Fitness Enhancement in Plants?

2019 ◽  
Vol 60 (9) ◽  
pp. 1953-1960 ◽  
Author(s):  
Misato Ohtani ◽  
Andreas Wachter
Keyword(s):  
Quality Control ◽  
Gene Regulation ◽  
Current Knowledge ◽  
Qualitative And Quantitative ◽  
Rna Quality ◽  
Quantitative Level ◽  
Splicing Variants ◽  
Rna Quality Control ◽  
Nonsense Mediated Mrna Decay ◽  
Environmental Responses

Abstract Post-transcriptional RNA quality control is a vital issue for all eukaryotes to secure accurate gene expression, both on a qualitative and quantitative level. Among the different mechanisms, nonsense-mediated mRNA decay (NMD) is an essential surveillance system that triggers degradation of both aberrant and physiological transcripts. By targeting a substantial fraction of all transcripts for degradation, including many alternative splicing variants, NMD has a major impact on shaping transcriptomes. Recent progress on the transcriptome-wide profiling and physiological analyses of NMD-deficient plant mutants revealed crucial roles for NMD in gene regulation and environmental responses. In this review, we will briefly summarize our current knowledge of the recognition and degradation of NMD targets, followed by an account of NMD’s regulation and physiological functions. We will specifically discuss plant-specific aspects of RNA quality control and its functional contribution to the fitness and environmental responses of plants.

scholarly journals The Giant Protein Titin: A Regulatory Node That Integrates Myocyte Signaling Pathways

2011 ◽  
Vol 286 (12) ◽  
pp. 9905-9912 ◽  
Author(s):  
Martina Krüger ◽  
Wolfgang A. Linke
Keyword(s):  
Quality Control ◽  
Gene Regulation ◽  
Signaling Pathways ◽  
Human Body ◽  
Protein Quality ◽  
Protein Quality Control ◽  
Muscle Cells ◽  
Scaffold Protein

Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly. However, recent evidence has established another important role for titin: that of a regulatory node integrating, and perhaps coordinating, diverse signaling pathways, particularly in cardiomyocytes. We review key findings within this emerging field, including those related to phosphorylation of the titin springs, and also discuss how titin participates in hypertrophic gene regulation and protein quality control.

Health communication ethics and CDC quality-control guidelines for information

2003 ◽  
Vol 118 (3) ◽  
pp. 193-196 ◽  
Author(s):  
Jeffrey W McKenna ◽  
Terry F Pechacek ◽  
Donna F Stroup
Keyword(s):  
Quality Control ◽  
Health Communication ◽  
Communication Ethics

Quality control and the medical record

1971 ◽  
Vol 127 (1) ◽  
pp. 101-105 ◽  
Author(s):  
L. L. Weed
Keyword(s):  
Quality Control ◽  
Medical Record
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