scholarly journals Spinal Cord Ventral Horns and Lymphoid Organ Involvement in Powassan Virus Infection in a Mouse Model

Viruses ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 220 ◽  
Author(s):  
Rodrigo Santos ◽  
Meghan Hermance ◽  
Benjamin Gelman ◽  
Saravanan Thangamani
Keyword(s):  
Spinal Cord ◽  
Virus Infection ◽  
Mouse Model ◽  
Lymphoid Organ ◽  
Organ Involvement ◽  
Powassan Virus

California serogroup and Powassan virus infection of cats

1987 ◽  
Vol 33 (8) ◽  
pp. 693-697 ◽  
Author(s):  
D. P. Keane ◽  
J. Parent ◽  
P. B. Little
Keyword(s):  
Spinal Cord ◽  
Virus Infection ◽  
Hemagglutination Inhibition ◽  
Snowshoe Hare ◽  
Powassan Virus ◽  
California Serogroup ◽  
The Brain

One hundred and seventy five sera from cats in Ontario, Canada, were tested for hemagglutination inhibition (HI) antibodies to three arboviruses; namely, Powassan (POW) of the Flavivirus serogroup, and Snowshoe hare (SSH) and Jamestown Canyon (JC) viruses of the California (CAL) serogroup. All sera were negative for antibodies to POW virus. Twelve cats possessed CAL serogroup antibodies including 3 with antibodies to SSH alone, 6 with antibodies to JC alone, and 3 with antibodies to both SSH and JC antigens. POW virus was inoculated into seven cats, one intracerebrally and six intravenously. Neurologic signs were not detected in any of the cats. Histologic lesions of a nonsuppurative encephalitis and encephalomyelitis were observed in the intracerebrally inoculated cat and in one of the intravenously inoculated cats, respectively. POW virus was not isolated from the brain or spinal cord of either of these two cats. HI antibodies were detected in the sera of all inoculated animals. HI antibodies were not detected in the CSF of any animal.

Mouse Model of Dengue Virus Infection with Serotypes 1 and 2 Clinical Isolates

BIO-PROTOCOL ◽  
2016 ◽  
Vol 6 (23) ◽  
Author(s):  
Satoru Watanabe ◽  
Kitti Wing Chan ◽  
Subhash Vasudevan
Keyword(s):  
Virus Infection ◽  
Mouse Model ◽  
Dengue Virus ◽  
Clinical Isolates ◽  
Dengue Virus Infection

scholarly journals Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: Implications for CNS complications

Glia ◽  
2021 ◽  
Author(s):  
Verena Schultz ◽  
Jennifer A. Barrie ◽  
Claire L. Donald ◽  
Colin L. Crawford ◽  
Margaret Mullin ◽  
...  
Keyword(s):  
Virus Infection ◽  
Mouse Model ◽  
Zika Virus ◽  
Perinatal Exposure ◽  
Zika Virus Infection

scholarly journals GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Natsuko Ohashi ◽  
Tomoya Terashima ◽  
Miwako Katagi ◽  
Yuki Nakae ◽  
Junko Okano ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Gene Therapy ◽  
Bone Marrow ◽  
Mouse Model ◽  
Lentiviral Vector ◽  
White Blood Cells ◽  
Glutamate Toxicity ◽  
Pathological Lesion ◽  
Arginase 1 ◽  
Therapy Strategy

AbstractAmyotrophic lateral sclerosis (ALS) is an intractable neurodegenerative disease. CD68-positive bone marrow (BM)-derived cells (BMDCs) accumulate in the pathological lesion in the SOD1(G93A) ALS mouse model after BM transplantation (BMT). Therefore, we investigated whether BMDCs can be applied as gene carriers for cell-based gene therapy by employing the accumulation of BMDCs. In ALS mice, YFP reporter signals were observed in 12–14% of white blood cells (WBCs) and in the spinal cord via transplantation of BM after lentiviral vector (LV) infection. After confirmation of gene transduction by LV with the CD68 promoter in 4–7% of WBCs and in the spinal cord of ALS mice, BM cells were infected with LVs expressing glutamate transporter (GLT) 1 that protects neurons from glutamate toxicity, driven by the CD68 promoter, which were transplanted into ALS mice. The treated mice showed improvement of motor behaviors and prolonged survival. Additionally, interleukin (IL)-1β was significantly suppressed, and IL-4, arginase 1, and FIZZ were significantly increased in the mice. These results suggested that GLT1 expression by BMDCs improved the spinal cord environment. Therefore, our gene therapy strategy may be applied to treat neurodegenerative diseases such as ALS in which BMDCs accumulate in the pathological lesion by BMT.

scholarly journals Permanent diaphragmatic deficits and spontaneous respiratory plasticity in a mouse model of incomplete cervical spinal cord injury

2021 ◽  
Vol 284 ◽  
pp. 103568
Author(s):  
Pauline Michel-Flutot ◽  
Arnaud Mansart ◽  
Therese B. Deramaudt ◽  
Isley Jesus ◽  
Kun-Ze Lee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mouse Model ◽  
Cervical Spinal Cord ◽  
Cervical Spinal Cord Injury ◽  
Cord Injury ◽  
Respiratory Plasticity

scholarly journals Development of a Novel Mouse Model for Dengue Virus Infection

Virology ◽  
1999 ◽  
Vol 263 (1) ◽  
pp. 70-77 ◽  
Author(s):  
J. An ◽  
J. Kimura-Kuroda ◽  
Y. Hirabayashi ◽  
K. Yasui
Keyword(s):  
Virus Infection ◽  
Mouse Model ◽  
Dengue Virus ◽  
Dengue Virus Infection
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