scholarly journals Intranasal Immunization with Influenza Virus-Like Particles Containing Membrane-Anchored Cholera Toxin B or Ricin Toxin B Enhances Adaptive Immune Responses and Protection against an Antigenically Distinct Virus

Viruses ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 115 ◽  
Author(s):  
Xianliang Ji ◽  
Zhiguang Ren ◽  
Na Xu ◽  
Lingnan Meng ◽  
Zhijun Yu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Immune Responses ◽  
Cholera Toxin ◽  
Adaptive Immune Responses ◽  
Toxin B ◽  
Virus Like Particles ◽  
Ricin Toxin ◽  
Cholera Toxin B ◽  
Adaptive Immune ◽  
Distinct Virus

scholarly journals Virus-Like Particles Are a Superior Platform for Presenting M2e Epitopes to Prime Humoral and Cellular Immunity against Influenza Virus

Vaccines ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 66 ◽  
Author(s):  
Ki-Hye Kim ◽  
Young-Man Kwon ◽  
Young-Tae Lee ◽  
Min-Chul Kim ◽  
Hye Hwang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Influenza Virus ◽  
Immune Responses ◽  
Cross Protection ◽  
Effective Vaccine ◽  
Vaccine Platform ◽  
Adaptive Immune Responses ◽  
Virus Like Particles ◽  
Adaptive Immune ◽  
Antigenic Properties

Influenza virus M2 protein has a highly conserved ectodomain (M2e) as a cross-protective antigenic target. We investigated the antigenic and immunogenic properties of tandem repeat M2e (5xM2e) proteins and virus-like particles (5xM2e VLP) to better understand how VLP and protein platform vaccines induce innate and protective adaptive immune responses. Despite the high antigenic properties of 5xM2e proteins, the 5xM2e VLP was superior to 5xM2e proteins in inducing IgG2a isotype antibodies, T cell responses, plasma cells and germinal center B cells as well as in conferring cross protection. Mice primed with 5xM2e VLP were found to be highly responsive to 5xM2e protein boost, overcoming the low immunogenicity and protective efficacy of 5xM2e proteins. Immunogenic differences between VLPs and proteins in priming immune responses might be due to an intrinsic ability of 5xM2e VLP to stimulate dendritic cells secreting T helper type 1 (Th1) cytokines. We also found that 5xM2e VLP was effective in inducing inflammatory cytokines and chemokines, and in recruiting macrophages, monocytes, neutrophils, and CD11b+ dendritic cells at the injection site. Therefore, this study provides evidence that 5xM2e VLP is an effective vaccine platform, inducing cross-protection by stimulating innate and adaptive immune responses.

scholarly journals Dendritic Cells in Innate and Adaptive Immune Responses against Influenza Virus

Viruses ◽  
2009 ◽  
Vol 1 (3) ◽  
pp. 1022-1034 ◽  
Author(s):  
Artur Summerfield ◽  
Kenneth McCullough
Keyword(s):  
Dendritic Cells ◽  
Influenza Virus ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune

Immunological tools for the assessment of both humoral and cellular immune responses in Foxes (Vulpes vulpes) using ovalbumin and cholera toxin B as an antigenic model

Vaccine ◽  
2004 ◽  
Vol 22 (31-32) ◽  
pp. 4163-4172 ◽  
Author(s):  
Magali Rolland-Turner ◽  
Guillaume Farre ◽  
Delphine Muller ◽  
Nelly Rouet ◽  
Franck Boue
Keyword(s):  
Immune Responses ◽  
Cholera Toxin ◽  
Vulpes Vulpes ◽  
Toxin B ◽  
Cholera Toxin B ◽  
Cellular Immune Responses ◽  
Cellular Immune

Use of a genetic cholera toxin B subunit/allergen fusion molecule as mucosal delivery system with immunosuppressive activity against Th2 immune responses

Vaccine ◽  
2007 ◽  
Vol 25 (50) ◽  
pp. 8395-8404 ◽  
Author(s):  
Merima Bublin ◽  
Elisabeth Hoflehner ◽  
Birgit Wagner ◽  
Christian Radauer ◽  
Stefan Wagner ◽  
...  
Keyword(s):  
Immune Responses ◽  
Cholera Toxin ◽  
Delivery System ◽  
Cholera Toxin B Subunit ◽  
Immunosuppressive Activity ◽  
Toxin B ◽  
Cholera Toxin B ◽  
B Subunit ◽  
Mucosal Delivery

scholarly journals Local and Systemic Immune Responses to Rectal Administration of Recombinant Cholera Toxin B Subunit in Humans

2001 ◽  
Vol 69 (6) ◽  
pp. 4125-4128 ◽  
Author(s):  
Marianne Jertborn ◽  
Inger Nordström ◽  
Anders Kilander ◽  
Cecil Czerkinsky ◽  
Jan Holmgren
Keyword(s):  
Immune Responses ◽  
Cholera Toxin ◽  
Immunoglobulin A ◽  
Rectal Administration ◽  
Antibody Responses ◽  
Cholera Toxin B Subunit ◽  
Toxin B ◽  
Cholera Toxin B ◽  
B Subunit ◽  
Antibody Secreting Cells

ABSTRACT The induction of immune responses to rectally administered recombinant cholera toxin B subunit (CTB) in humans was studied. Three immunizations induced high levels of CTB-specific antibody-secreting cells, particular of the immunoglobulin A isotype, in both rectum and peripheral blood. Antitoxin antibody responses in rectal secretions and serum were also found.

scholarly journals Generation of Adaptive Immune Responses Following Influenza Virus Challenge is Not Compromised by Pre-Treatment with the TLR-2 Agonist Pam2Cys

2015 ◽  
Vol 6 ◽  
Author(s):  
Edin Jessica Mifsud ◽  
Amabel C. L. Tan ◽  
Lorena Elizabeth Brown ◽  
Brendon Yew Loong Chua ◽  
David C. Jackson
Keyword(s):  
Influenza Virus ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Virus Challenge ◽  
Adaptive Immune ◽  
Pre Treatment
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