scholarly journals Mutation Distribution in the NSP4 Protein in Rotaviruses Isolated from Mexican Children with Moderate to Severe Gastroenteritis

Viruses ◽  
2013 ◽  
Vol 5 (3) ◽  
pp. 792-805 ◽  
Author(s):  
Guadalupe González-Ochoa ◽  
Griselda Menchaca ◽  
Carlos Hernández ◽  
Cristina Rodríguez ◽  
Reyes Tamez ◽  
...  
Keyword(s):  
Mexican Children ◽  
Severe Gastroenteritis ◽  
Nsp4 Protein ◽  
Mutation Distribution

Attenuation of a human rotavirus vaccine candidate did not correlate with mutations in the NSP4 protein gene.

1997 ◽  
Vol 71 (8) ◽  
pp. 6267-6270 ◽  
Author(s):  
R L Ward ◽  
B B Mason ◽  
D I Bernstein ◽  
D S Sander ◽  
V E Smith ◽  
...  
Keyword(s):  
Protein Gene ◽  
Vaccine Candidate ◽  
Rotavirus Vaccine ◽  
Human Rotavirus ◽  
Nsp4 Protein

scholarly journals Glutamine: Beneficial to prevent oral mucositis in Mexican children with acute lymphoblastic leukemia?

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Miriam R. Caselin-García ◽  
Katja Stein ◽  
Miguel R. Kumazawa-Ichikawa ◽  
Oscar González-Ramella ◽  
Edgar M. Vásquez-Garibay ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Oral Mucositis ◽  
Lymphoblastic Leukemia ◽  
Mexican Children

scholarly journals Association of Genetic Polymorphisms and Serum Levels of IL-6 and IL-8 with the Prognosis in Children with Neuroblastoma

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 529
Author(s):  
Silvia Selene Moreno-Guerrero ◽  
Arturo Ramírez-Pacheco ◽  
Luz María Rocha-Ramírez ◽  
Gabriela Hernández-Pliego ◽  
Pilar Eguía-Aguilar ◽  
...  
Keyword(s):  
Overall Survival ◽  
Genetic Polymorphisms ◽  
Poor Prognosis ◽  
Serum Levels ◽  
Control Group ◽  
Mexican Children ◽  
Genotype Frequencies ◽  
Pcr Rflp ◽  
The Impact ◽  
Circulating Levels

There is evidence that high circulating levels of IL-6 and IL-8 are markers of a poor prognosis in various types of cancer, including NB. The participation of these cytokines in the tumor microenvironment has been described to promote progression and metastasis. Our objective was to evaluate the prognostic role of genetic polymorphisms and serum levels of IL-6 and IL-8 in a cohort of Mexican pediatric patients with NB. The detection of the SNPs rs1800795 IL-6 and rs4073 and rs2227306 IL-8 was carried out by PCR-RFLP and the levels of cytokines were determined by the ELISA method. We found elevated circulating levels of IL-8 and IL-6 in NB patients compared to the control group. The genotype frequencies of the rs1800795 IL-6 and rs4073 IL-8 variants were different between the patients with NB and the control group. Likewise, the survival analysis showed that the GG genotypes of rs1800795 IL-6 (p = 0.014) and AA genotypes of rs4073 IL-8 (p = 0.002), as well as high levels of IL-6 (p = 0.009) and IL-8 (p = 0.046), were associated with lower overall survival. We confirmed the impact on an adverse prognosis in a multivariate model. This study suggests that the SNPs rs1800795 IL-6 and rs4073 IL-8 and their serum levels could be promising biomarkers of a poor prognosis, associated with overall survival, metastasis, and a high risk in Mexican children with NB.

scholarly journals Time series analysis of the relationship between diarrhea in children and Rota 2 vaccine in the Fanteakwa District of the eastern region of Ghana

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
James Atampiiga Avoka ◽  
Elvis J. Dun-Dery ◽  
Issah Seidu ◽  
Armel N. E. Abou ◽  
Paul Twene ◽  
...  
Keyword(s):  
Pearson Correlation ◽  
Developed Countries ◽  
Seasonal Effects ◽  
Eastern Region ◽  
Least Developed Countries ◽  
R Software ◽  
Significant Difference ◽  
Severe Gastroenteritis ◽  
Access To Medical Care ◽  
The Relationship

Abstract Background Rotavirus is considered the main causal factor of severe gastroenteritis among infants and children globally. The association with severe rotavirus infection is mostly worse among the least developed countries, mainly due to inadequate access to medical care and poverty. This study was conducted to determine the seasonal effects in respect of diarrhea cases in children, the association between diarrhea cases and Rota2 vaccine in the Fanteakwa District of the Eastern Region of Ghana. Methods The study compares monthly diarrhea cases against children vaccinated with Rota2 extracted from DHIMS2 spanning May 2012 to December 2017 in Fanteakwa District. A univariate association between diarrhea cases and children vaccinated with Rota 2 was conducted using the R-software version 3.4.4 with the use of forecast, tseries and TSAPred. Pearson Correlation coefficient was also computed between monthly diarrhea cases and Rota 2 as well as lagged values of Rota 2 and Diarrhea cases. Results The study shows that February recorded the highest average number of diarrhea cases (172) over the period 2012 to 2017 with a standard deviation of 59. However, a one-way analysis of variance shows a significant difference amongst the monthly averages with an F-statistic of 0.042 and P-value of 0.064. It is observed that the correlations between each of the Rota2 doses and the lagged cases are positive, showing higher Rota2 doses a month ago ((Xt − 1),0.346 to0.735), two months ago ((Xt − 2),0.383 to 0.746), three months ago ((Xt − 3), 0.330 to 0.737) and four months ago ((Xt − 4), 0.236 to 0.723) are associated with lower diarrhea cases. The results also show that an increase in the previous two month’s Rota2 figures by 100 is associated with a significant decrease in the currently expected diarrhea cases by approximately 36. Conclusion Seasonal variations exist in the occurrence of diarrhea in children, with January recording the highest number of diarrhea cases (172). There is a relationship between episodes of diarrhea in children and Rota2 (p-value = 0.064); thus, the more children are vaccinated with Rota2, the less diarrhea cases are recorded. Diarrhea cases in Fanteakwa district are generally low, except 2013 and 2016 where the cases are higher than the rest of the other years.

scholarly journals Self-Reported Dental Caries by Mexican Elementary and Middle-School Schoolchildren in the Context of Socioeconomic Indicators: A National Ecological Study

Children ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 289
Author(s):  
Juan Fernando Casanova-Rosado ◽  
Alejandro José Casanova-Rosado ◽  
Mirna Minaya-Sánchez ◽  
Juan Alejandro Casanova-Sarmiento ◽  
José Luis Robles-Minaya ◽  
...  
Keyword(s):  
Middle School ◽  
Dental Caries ◽  
School Health ◽  
Ecological Study ◽  
Self Report ◽  
Socioeconomic Indicators ◽  
National Surveys ◽  
Socioeconomic Variables ◽  
Food Purchases ◽  
Mexican Children

The objective of the present research was to quantify the association between dental caries self-report and socioeconomic indicators in Mexican children. An ecological study included a self-report of dental caries in schoolchildren enrolled in public elementary and middle schools derived from the National School Health Survey. A total of 73,560 schoolchildren (representing 19,745,366 students) aged 5 to 16 years were included. Socioeconomic variables included were scales depicting physical characteristics of housing, purchasing power, etc. used in national surveys in Mexico to measure deprivation, poverty, and income inequality in official data. Data were analyzed in Stata using Spearman’s correlation test. For the most part, no association (p > 0.05) was found between caries self-report, socioeconomic variables, or the Gini index. However, caries self-report in elementary schoolchildren and total (elementary + middle-school) schoolchildren groups was positively correlated (p < 0.05) with two poverty variables: extreme poverty by income (value of personal food purchases per month) and poverty by income (value of personal food and non-food purchases per month). National data for dental caries self-report were associated—at the ecological level—with a few socioeconomic indicators but not with most of the usual and customary indicators used in national surveys in Mexico.

scholarly journals Clinical features of gastroenteritis during a large waterborne Campylobacter outbreak in Askøy, Norway

Infection ◽  
2021 ◽  
Author(s):  
Knut Erik Emberland ◽  
K.-A. Wensaas ◽  
S. Litleskare ◽  
A. Iversen ◽  
K. Hanevik ◽  
...  
Keyword(s):  
Clinical Features ◽  
Joint Pain ◽  
Text Message ◽  
Warning System ◽  
Acute Illness ◽  
Common Symptom ◽  
Web Based ◽  
Severe Gastroenteritis ◽  
Bloody Stools ◽  
Self Administered Questionnaire

Abstract Purpose Outbreaks of Campylobacter infection are common, but studies exploring the clinical features of acute illness in the outbreak setting are scarce in existing literature. The main purpose of the present study was to investigate the clinical features of self-reported acute illness in gastroenteritis cases during a large waterborne Campylobacter outbreak in Askøy municipality, Norway, in 2019. Methods A web-based self-administered questionnaire, and invitation to participate was sent by the municipality of Askøy as text message to mobile phones using the municipality’s warning system to the inhabitants during the ongoing outbreak. Results Out of 3624 participants, 749 (20.7%) were defined as cases, of which 177 (23.6%) reported severe gastroenteritis. The most common symptoms were loose stools (90.7%), abdominal pain (89.3%) and diarrhea (88.9%), whereas 63.8% reported fever, 50.2% joint pain and 14.2% bloody stools. Tiredness, a symptom non-specific to gastroenteritis, was the overall most common symptom (91.2%). Conclusion About one in four of the cases reported symptoms consistent with severe gastroenteritis. We found more joint pain and less bloody stools than reported in published studies of laboratory confirmed campylobacteriosis cases. Tiredness was common in the current study, although rarely described in previous literature of acute illness in the outbreak setting.

scholarly journals CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways

2021 ◽  
Author(s):  
Dafné Moreno Lorenzana ◽  
María del Rocío Juárez Velázquez ◽  
Adriana Reyes León ◽  
Daniel Martínez Anaya ◽  
Adrián Hernández Monterde ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Signaling Pathways ◽  
Lymphoblastic Leukemia ◽  
Surrogate Markers ◽  
Gene Fusions ◽  
Mexican Children ◽  
Recurrent Gene Fusions

scholarly journals The influence of perceived parenting on substance initiation among Mexican children

2019 ◽  
Vol 97 ◽  
pp. 97-103 ◽  
Author(s):  
Alejandro L. Vázquez ◽  
Melanie M. Domenech Rodríguez ◽  
Nancy G. Amador Buenabad ◽  
Marycarmen N. Bustos Gamiño ◽  
María de Lourdes Gutierrez López ◽  
...  
Keyword(s):  
Perceived Parenting ◽  
Mexican Children
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