scholarly journals Viral Determinants of HIV-1 Macrophage Tropism

Viruses ◽  
2011 ◽  
Vol 3 (11) ◽  
pp. 2255-2279 ◽  
Author(s):  
Christopher J. A. Duncan ◽  
Quentin J. Sattentau
Keyword(s):  
Macrophage Tropism ◽  
Viral Determinants ◽  
Hiv 1

scholarly journals Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies

Retrovirology ◽  
2010 ◽  
Vol 7 (1) ◽  
pp. 48 ◽  
Author(s):  
Kathryn H Richards ◽  
Marlén MI Aasa-Chapman ◽  
Áine McKnight ◽  
Paul R Clapham
Keyword(s):  
Neutralizing Antibodies ◽  
Macrophage Tropism ◽  
Hiv 1

scholarly journals The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

Retrovirology ◽  
2008 ◽  
Vol 5 (1) ◽  
pp. 89 ◽  
Author(s):  
Fiorella Rossi ◽  
Bianca Querido ◽  
Manideepthi Nimmagadda ◽  
Simon Cocklin ◽  
Sonia Navas-Martín ◽  
...  
Keyword(s):  
Envelope Glycoprotein ◽  
Entry Inhibitors ◽  
Macrophage Tropism ◽  
Altered Sensitivity ◽  
V3 Region ◽  
Hiv 1

scholarly journals Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue

Retrovirology ◽  
2012 ◽  
Vol 9 (1) ◽  
pp. 20 ◽  
Author(s):  
Maria P Gonzalez-Perez ◽  
Olivia J O'Connell ◽  
Rongheng Lin ◽  
William M Sullivan ◽  
Jeanne Bell ◽  
...  
Keyword(s):  
Independent Evolution ◽  
Macrophage Tropism ◽  
Immune Tissue ◽  
Hiv 1

Cellular and viral determinants that regulate HIV-1 infection in macrophages

1994 ◽  
Vol 56 (3) ◽  
pp. 278-288 ◽  
Author(s):  
Mario Stevenson ◽  
Howard E. Gendelman
Keyword(s):  
Viral Determinants ◽  
Hiv 1

scholarly journals Macrophage Tropism in Pathogenic HIV-1 and SIV Infections

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1077
Author(s):  
Matthew Moeser ◽  
Joshua R. Nielsen ◽  
Sarah B. Joseph
Keyword(s):  
Macrophage Infection ◽  
Myeloid Lineage ◽  
Viral Loads ◽  
Disease States ◽  
Macrophage Tropism ◽  
Natural Hosts ◽  
Primary Driver ◽  
Primate Lentiviruses ◽  
Post Entry ◽  
Hiv 1

Most myeloid lineage cells express the receptor and coreceptors that make them susceptible to infection by primate lentiviruses (SIVs and HIVs). However, macrophages are the only myeloid lineage cell commonly infected by SIVs and/or HIVs. The frequency of infected macrophages varies greatly across specific host and virus combinations as well as disease states, with infection rates being greatest in pathogenic SIV infections of non-natural hosts (i.e., Asian nonhuman primates (Asian NHPs)) and late in untreated HIV-1 infection. In contrast, macrophages from natural SIV hosts (i.e., African NHPs) are largely resistant to infection due to entry and/or post-entry restriction mechanisms. These highly variable rates of macrophage infection may stem from differences in the host immune environment, entry and post-entry restriction mechanisms, the ability of a virus to adapt to efficiently infect macrophages, and the pleiotropic effects of macrophage-tropism including the ability to infect cells lacking CD4 and increased neutralization sensitivity. Questions remain about the relationship between rates of macrophage infection and viral pathogenesis, with some evidence suggesting that elevated levels of macrophage infection may contribute to greater pathogenesis in non-natural SIV hosts. Alternatively, extensive infection of macrophages may only emerge in the context of high viral loads and immunodeficiency, making it a symptom of highly pathogenic infections, not a primary driver of pathogenesis.

Viral determinants of HIV-1 sufficient to extend tropism to macrophages are distinct from the determinants that control the cytopathic phenotype in HL-60 cells

AIDS ◽  
1997 ◽  
Vol 11 (14) ◽  
pp. 1681-1688 ◽  
Author(s):  
Nancy L. DiFronzo ◽  
Cynthia A. Pise-Masison ◽  
Roberto Fernandez-Larsson ◽  
Christie A. Holland
Keyword(s):  
Viral Determinants ◽  
Hiv 1

scholarly journals Efficiency of Bridging-Sheet Recruitment Explains HIV-1 R5 Envelope Glycoprotein Sensitivity to Soluble CD4 and Macrophage Tropism

2012 ◽  
Vol 87 (1) ◽  
pp. 187-198 ◽  
Author(s):  
O. O'Connell ◽  
A. Repik ◽  
J. D. Reeves ◽  
M. P. Gonzalez-Perez ◽  
B. Quitadamo ◽  
...  
Keyword(s):  
Envelope Glycoprotein ◽  
Macrophage Tropism ◽  
Hiv 1 ◽  
Soluble Cd4

scholarly journals The efficiency of bridging sheet recruitment determines HIV-1 R5 envelope sensitivity to soluble CD4 and macrophage tropism

Retrovirology ◽  
2012 ◽  
Vol 9 (Suppl 2) ◽  
pp. P141
Author(s):  
O O'Connell ◽  
A Repik ◽  
JD Reeves ◽  
MP Gonzalez-Perez ◽  
B Quitadamo ◽  
...  
Keyword(s):  
Macrophage Tropism ◽  
Hiv 1 ◽  
Soluble Cd4

Macrophage Tropism of HIV-1

1990 ◽  
Vol 6 (8) ◽  
pp. 1017-1021 ◽  
Author(s):  
SUZANNE GARTNER ◽  
MIKULAS POPOVIC
Keyword(s):  
Macrophage Tropism ◽  
Hiv 1
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