scholarly journals 1984—Discovery of the First Anti-HIV Drug, Suramin

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1646
Author(s):  
Erik De Clercq
Keyword(s):  
Immune Deficiency ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
40Th Anniversary ◽  
First Time ◽  
Acquired Immune Deficiency ◽  
Anti Hiv

In 2021, we commemorate the 40th anniversary of the identification of the disease AIDS, the acquired immune deficiency syndrome, a name that for the first time in history was launched in 1981 [...]

scholarly journals Pengklonaan Plasmid Rekombinan gp125-gp36 Human Immunodeficiency Virus tipe 2 (HIV-2) untuk Pengembangan Sistem Diagnostik HIV-2

2019 ◽  
Vol 8 (1) ◽  
pp. 59-66
Author(s):  
Fathurrohim Fathurrohim ◽  
Silvia Tri Widyaningtyas ◽  
Budiman Bela
Keyword(s):  
Immune Deficiency ◽  
Human Immunodeficiency Virus ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Rapid Diagnostic Tests ◽  
Immunodeficiency Virus ◽  
Acquired Immune Deficiency ◽  
Anti Hiv ◽  
Hiv 1

AbstractFrom 36.9 million people infected by the Human Immunodeficiency Virus (HIV) at the end of 2018 in the whole world, 1-2 million are infected by HIV-2. Accurately diagnostic is required to ensure whether an individual has been infected HIV-1, HIV-2, or HIV-1 and HIV-2 co-infection. HIV-2 diagnostic error using rapid diagnostic tests (RDT) frequently occurs. Misdiagnostic of HIV-2 infection may cause treatment failure which leads to the development of Acquired Immune Deficiency Syndrome (AIDS). In this study, expression plasmid pQE80L-gp125-gp36 HIV-2 that can produce recombinant antigen gp125-gp36 HIV-2 was successfully constructed and verified properly. The antigen is based on multiepitope, immunodominant and sustainable properties obtained by bioinformatics study. Plasmid pQE80L-gp125-gp36 HIV-2 may be used to produce recombinant antigens that benefit to detect anti-HIV-2 antibodies in an individual. AbstrakDari 36,9 juta individu yang terinfeksi oleh Human Immunodeficiency Virus (HIV) pada akhir tahun 2018 di seluruh dunia, terdapat sekitar 1 – 2 juta individu yang terinfeksi dengan HIV-2. Diagnostik yang akurat diperlukan untuk menentukan apakah suatu individu telah terinfeksi HIV-1, HIV-2 atau koinfeksi HIV-1 dan HIV-2. Kesalahan diagnostik HIV-2 menggunakan rapid diagnostic tests (RDT) sering sekali terjadi. Misdiagnosis infeksi HIV-2 dapat menyebabkan kegagalan pengobatan yang berujung pada perkembangan Acquired Immune Deficiency Syndrome (AIDS). Pada penelitian ini plasmid pQE80L-gp125-gp36 HIV-2 pengekspresi antigen rekombinan gp125-gp36 HIV-2 telah berhasil dikonstruksi dan terverifikasi dengan baik. Antigen tersebut berbasis multiepitop, immunodominan dan bersifat lestari yang didapatkan dari studi bioinformatik. Plasmid pQE80L-gp125-gp36 HIV-2 dapat digunakan untuk memproduksi antigen rekombinan yang dapat dimanfaatkan untuk mendeteksi antibodi anti HIV-2 pada suatu individu.

Arteriopathy in Children with Acquired Immune Deficiency Syndrome

1987 ◽  
Vol 7 (3) ◽  
pp. 261-275 ◽  
Author(s):  
Vijay Joshi ◽  
Bruce Pawel ◽  
Edward Connor ◽  
Leroy Sharer ◽  
James Oleske ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Acquired Immune Deficiency
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