scholarly journals Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1362
Author(s):  
Elijane de Fátima Redivo ◽  
Camila Bôtto Menezes ◽  
Márcia da Costa Castilho ◽  
Marianna Brock ◽  
Evela da Silva Magno ◽  
...  
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Zika Virus ◽  
Descriptive Analysis ◽  
First Trimester ◽  
Adverse Outcomes ◽  
Rt Pcr ◽  
Zika Virus Infection ◽  
Adverse Pregnancy ◽  
In Pregnancy

The epidemic transmission of Zika virus (ZIKV) in Brazil has been identified as a cause of microcephaly and other neurological malformations in the babies of ZIKV-infected women. The frequency of adverse outcomes of Zika virus infection (ZIKVi) in pregnancy differs depending on the characteristics of exposure to infection, the time of recruitment of research participants, and the outcomes to be observed. This study provides a descriptive analysis—from the onset of symptoms to delivery—of a cohort registered as having maternal ZIKVi in pregnancy, from November 2015 to December 2016. Suspected cases were registered at a referral center for infectious and tropical diseases in Manaus, in the Amazonian region of Brazil. Of 834 women notified, 762 women with confirmed pregnancies were enrolled. Reverse-transcriptase polymerase chain reaction (RT-PCR) confirmed ZIKVi in 42.3% of the cohort. In 35.2% of the cohort, ZIKV was the sole infection identified. Severe adverse pregnancy outcomes (miscarriage, stillbirth, or microcephaly) were observed in both RT-PCR ZIKV-positive (5.0%) and ZIKV-negative (1.8%) cases (RR 3.1; 95% IC 1.4–7.3; p < 0.05), especially during the first trimester of pregnancy (RR 6.2, 95% IC 2.3–16.5; p < 0.001). Although other infectious rash diseases were observed in the pregnant women in the study, having confirmed maternal ZIKVi was the most important risk factor for serious adverse pregnancy events.

scholarly journals Zika Virus Infection in a Cohort of Pregnant Women with Exanthematic Disease in Manaus, Brazilian Amazon

2020 ◽  
Author(s):  
Elijane de Fátima Redivo ◽  
Camila Helena Bôtto Menezes ◽  
Márcia da Costa Castilho ◽  
Marianna Facchinetti Brock ◽  
Evela da Silva Magno ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcomes ◽  
Zika Virus ◽  
Descriptive Analysis ◽  
First Trimester ◽  
Adverse Pregnancy Outcomes ◽  
Rt Pcr ◽  
Zikv Infection ◽  
Adverse Pregnancy ◽  
In Pregnancy

The epidemic transmission of Zika virus (ZIKV) in Brazil has been identified as a cause of microcephaly and other neurological malformations in babies of ZIKV-infected women. This study provides a descriptive analysis, since the onset of symptoms to the delivery, of a cohort who were registered as having ZIKV infection in pregnancy, from November 2015 to December 2016. Suspected cases were registered at a referral center for infectious and tropical diseases in Manaus, in the Brazilian Amazonian region. A total of 834 women with suspected ZIKV in pregnancy were included, of whom 91.4% had confirmed pregnancy. Reverse-transcriptase polymerase chain reaction (RT-PCR) confirmed ZIKV infection in 42.2% of the cohort. In 35.2% of the cohort, ZIKV was the sole infection identified. Severe adverse pregnancy outcomes (abortion, stillbirth, or microcephaly) were observed in both RT-PCR ZIKV-positive (4.96%) and ZIKV-negative (2.15%) cases. Women with suspected ZIKV infection were much more likely to have adverse pregnancy outcomes if they were symptomatic during the first trimester of pregnancy (odds ratio 10.5; 95% confidence interval 4.0&ndash;27.0; p&lt;0.001). Among pregnant women with suspected ZIKV infection, the occurrence of symptoms in the first trimester is associated with an especially high risk of severe adverse pregnancy outcomes.

scholarly journals Zika virus infection in pregnancy: Establishing a case definition for clinical research on pregnant women with rash in an active transmission setting

2019 ◽  
Vol 13 (10) ◽  
pp. e0007763 ◽  
Author(s):  
Ricardo Arraes de Alencar Ximenes ◽  
Demócrito de Barros Miranda-Filho ◽  
Elizabeth B. Brickley ◽  
Ulisses Ramos Montarroyos ◽  
Celina Maria Turchi Martelli ◽  
...  
Keyword(s):  
Virus Infection ◽  
Clinical Research ◽  
Pregnant Women ◽  
Zika Virus ◽  
Case Definition ◽  
Transmission Setting ◽  
Zika Virus Infection ◽  
In Pregnancy

scholarly journals Pregnancy, Birth, Infant, and Early Childhood Neurodevelopmental Outcomes among a Cohort of Women with Symptoms of Zika Virus Disease during Pregnancy in Three Surveillance Sites, Project Vigilancia de Embarazadas con Zika (VEZ), Colombia, 2016–2018

2021 ◽  
Vol 6 (4) ◽  
pp. 183
Author(s):  
Marcela Mercado-Reyes ◽  
Suzanne M. Gilboa ◽  
Diana Valencia ◽  
Marcela Daza ◽  
Van T. Tong ◽  
...  
Keyword(s):  
Early Childhood ◽  
Virus Infection ◽  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Zika Virus ◽  
Virus Disease ◽  
Adverse Outcomes ◽  
National Surveillance ◽  
Neurodevelopmental Outcomes ◽  
Zika Virus Infection

Project Vigilancia de Embarazadas con Zika (VEZ), an intensified surveillance of pregnant women with symptoms of the Zika virus disease (ZVD) in Colombia, aimed to evaluate the relationship between symptoms of ZVD during pregnancy and adverse pregnancy, birth, and infant outcomes and early childhood neurodevelopmental outcomes. During May–November 2016, pregnant women in three Colombian cities who were reported with symptoms of ZVD to the national surveillance system, or with symptoms of ZVD visiting participating clinics, were enrolled in Project VEZ. Data from maternal and pediatric (up to two years of age) medical records were abstracted. Available maternal specimens were tested for the presence of the Zika virus ribonucleic acid and/or anti-Zika virus immunoglobulin antibodies. Of 1213 enrolled pregnant women with symptoms of ZVD, 1180 had a known pregnancy outcome. Results of the Zika virus laboratory testing were available for 569 (48.2%) pregnancies with a known pregnancy outcome though testing timing varied and was often distal to the timing of symptoms; 254 (21.5% of the whole cohort; 44.6% of those with testing results) were confirmed or presumptive positive for the Zika virus infection. Of pregnancies with a known outcome, 50 (4.2%) fetuses/infants had Zika-associated brain or eye defects, which included microcephaly at birth. Early childhood adverse neurodevelopmental outcomes were more common among those with Zika-associated birth defects than among those without and more common among those with laboratory evidence of a Zika virus infection compared with the full cohort. The proportion of fetuses/infants with any Zika-associated brain or eye defect was consistent with the proportion seen in other studies. Enhancements to Colombia’s existing national surveillance enabled the assessment of adverse outcomes associated with ZVD in pregnancy.

scholarly journals Defining Zika virus infection in pregnant women

2019 ◽  
Vol 113 (7) ◽  
pp. 290-290
Author(s):  
Carlo Ticconi ◽  
Giovanni Rezza
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Zika Virus ◽  
Zika Virus Infection

scholarly journals 694: Middle cerebral artery Dopplers and adverse neonatal outcomes among pregnant women with Zika virus infection

2020 ◽  
Vol 222 (1) ◽  
pp. S439
Author(s):  
Thalia Wong ◽  
Jose Paulo Pereira ◽  
Nasim Sobhani ◽  
Renan Fonseca Cardozo ◽  
Helena Abreu Valle ◽  
...  
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Zika Virus ◽  
Neonatal Outcomes ◽  
Zika Virus Infection ◽  
Adverse Neonatal Outcomes

scholarly journals Association of Prenatal Ultrasonographic Findings With Adverse Neonatal Outcomes Among Pregnant Women With Zika Virus Infection in Brazil

2018 ◽  
Vol 1 (8) ◽  
pp. e186529 ◽  
Author(s):  
Jose Paulo Pereira ◽  
Karin Nielsen-Saines ◽  
Jeffrey Sperling ◽  
Melanie M. Maykin ◽  
Luana Damasceno ◽  
...  
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Zika Virus ◽  
Neonatal Outcomes ◽  
Zika Virus Infection ◽  
Adverse Neonatal Outcomes

scholarly journals ISUOG Interim Guidance on ultrasound for Zika virus infection in pregnancy: information for healthcare professionals

2016 ◽  
Vol 47 (4) ◽  
pp. 530-532 ◽  
Author(s):  
A. T. Papageorghiou ◽  
B. Thilaganathan ◽  
C. M. Bilardo ◽  
A. Ngu ◽  
G. Malinger ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Healthcare Professionals ◽  
Zika Virus Infection ◽  
In Pregnancy

Diagnosis of Zika virus infection in pregnant women travelling to or residing in endemic areas

2016 ◽  
Vol 16 (7) ◽  
pp. 771-772 ◽  
Author(s):  
Emanuele Nicastri ◽  
Concetta Castilletti ◽  
Antonino Di Caro ◽  
Maria R Capobianchi ◽  
Giuseppe Ippolito
Keyword(s):  
Virus Infection ◽  
Pregnant Women ◽  
Zika Virus ◽  
Zika Virus Infection ◽  
Endemic Areas
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