scholarly journals Special Issue “Recent Advances in Morbillivirus Vaccine Development and Oncolytic Virotherapy”

Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 341
Author(s):  
Liang-Tzung Lin
Keyword(s):  
Vaccine Development ◽  
Rna Viruses ◽  
Oncolytic Virotherapy ◽  
Special Issue ◽  
Negative Strand ◽  
Recent Advances

Members of the Morbillivirus genus are enveloped, negative-strand RNA viruses that include a number of highly contagious pathogens important to humans and animals [...]

scholarly journals Investigating the Interaction between Negative Strand RNA Viruses and Their Hosts for Enhanced Vaccine Development and Production

Vaccines ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 59
Author(s):  
Kostlend Mara ◽  
Meiling Dai ◽  
Aaron M. Brice ◽  
Marina R. Alexander ◽  
Leon Tribolet ◽  
...  
Keyword(s):  
Immune Responses ◽  
Vaccine Development ◽  
Rna Viruses ◽  
Vaccine Design ◽  
Integrated Approach ◽  
Control Measures ◽  
Effective Control ◽  
Negative Strand ◽  
Zoonotic Pathogens ◽  
Host Pathogen

The current pandemic has highlighted the ever-increasing risk of human to human spread of zoonotic pathogens. A number of medically-relevant zoonotic pathogens are negative-strand RNA viruses (NSVs). NSVs are derived from different virus families. Examples like Ebola are known for causing severe symptoms and high mortality rates. Some, like influenza, are known for their ease of person-to-person transmission and lack of pre-existing immunity, enabling rapid spread across many countries around the globe. Containment of outbreaks of NSVs can be difficult owing to their unpredictability and the absence of effective control measures, such as vaccines and antiviral therapeutics. In addition, there remains a lack of essential knowledge of the host–pathogen response that are induced by NSVs, particularly of the immune responses that provide protection. Vaccines are the most effective method for preventing infectious diseases. In fact, in the event of a pandemic, appropriate vaccine design and speed of vaccine supply is the most critical factor in protecting the population, as vaccination is the only sustainable defense. Vaccines need to be safe, efficient, and cost-effective, which is influenced by our understanding of the host–pathogen interface. Additionally, some of the major challenges of vaccines are the establishment of a long-lasting immunity offering cross protection to emerging strains. Although many NSVs are controlled through immunisations, for some, vaccine design has failed or efficacy has proven unreliable. The key behind designing a successful vaccine is understanding the host–pathogen interaction and the host immune response towards NSVs. In this paper, we review the recent research in vaccine design against NSVs and explore the immune responses induced by these viruses. The generation of a robust and integrated approach to development capability and vaccine manufacture can collaboratively support the management of outbreaking NSV disease health risks.

scholarly journals Recent Advances in Kinase Drug Discovery Part I: The Editors’ Take

2021 ◽  
Vol 22 (14) ◽  
pp. 7560
Author(s):  
Julie A. Tucker ◽  
Mathew P. Martin
Keyword(s):  
Drug Discovery ◽  
Research Articles ◽  
Special Issue ◽  
Recent Advances ◽  
Enzyme Family ◽  
Selection Of

This special issue on Advances in Kinase Drug Discovery provides a selection of research articles and topical reviews covering all aspects of drug discovery targeting the phosphotransferase enzyme family [...]

scholarly journals Special Issue: Advances in Computational Electromagnetics

2021 ◽  
Vol 7 (6) ◽  
pp. 89
Author(s):  
Valerio De Santis
Keyword(s):  
Rare Earth ◽  
Magnetic Materials ◽  
Permanent Magnets ◽  
Computational Electromagnetics ◽  
Superconducting Materials ◽  
Special Issue ◽  
Full Characterization ◽  
Recent Advances

Recent advances in computational electromagnetics (CEMs) have made the full characterization of complex magnetic materials possible, such as superconducting materials, composite or nanomaterials, rare-earth free permanent magnets, etc [...]

scholarly journals Special Issue on “Recent Advances in Population Balance Modeling”

Processes ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 122
Author(s):  
Seyed Soheil Mansouri ◽  
Heiko Briesen ◽  
Krist V. Gernaey ◽  
Ingmar Nopens
Keyword(s):  
Population Balance ◽  
Special Issue ◽  
Modeling Framework ◽  
Population Balance Modeling ◽  
Recent Advances

Population Balance Modeling (PBM) is a powerful modeling framework that allows the prediction of the dynamics of distributed properties of a population of individuals at the mesoscale [...]

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