scholarly journals In Search of Covariates of HIV-1 Subtype B Spread in the United States—A Cautionary Tale of Large-Scale Bayesian Phylogeography

Viruses ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 182 ◽  
Author(s):  
Samuel L. Hong ◽  
Simon Dellicour ◽  
Bram Vrancken ◽  
Marc A. Suchard ◽  
Michael T. Pyne ◽  
...  

Infections with HIV-1 group M subtype B viruses account for the majority of the HIV epidemic in the Western world. Phylogeographic studies have placed the introduction of subtype B in the United States in New York around 1970, where it grew into a major source of spread. Currently, it is estimated that over one million people are living with HIV in the US and that most are infected with subtype B variants. Here, we aim to identify the drivers of HIV-1 subtype B dispersal in the United States by analyzing a collection of 23,588 pol sequences, collected for drug resistance testing from 45 states during 2004–2011. To this end, we introduce a workflow to reduce this large collection of data to more computationally-manageable sample sizes and apply the BEAST framework to test which covariates associate with the spread of HIV-1 across state borders. Our results show that we are able to consistently identify certain predictors of spread under reasonable run times across datasets of up to 10,000 sequences. However, the general lack of phylogenetic structure and the high uncertainty associated with HIV trees make it difficult to interpret the epidemiological relevance of the drivers of spread we are able to identify. While the workflow we present here could be applied to other virus datasets of a similar scale, the characteristic star-like shape of HIV-1 phylogenies poses a serious obstacle to reconstructing a detailed evolutionary and spatial history for HIV-1 subtype B in the US.

PEDIATRICS ◽  
1986 ◽  
Vol 77 (5) ◽  
pp. 781-782
Author(s):  
KATHERINE K. CHRISTOFFEL ◽  
TOM CHRISTOFFEL

THE ISSUE There are an estimated 40 to 50 million handguns in the United States, with approximately 2 million more being manufactured annually1 (The New York Times, July 9, 1985, p 16). The high prevalence of handgun injury in the United States is unique in all the world and is increasing. Children are among the growing legions of US citizens harmed by the handgun epidemic.2 The effort to control handguns is focussed on developing laws to control their manufacture, importation, purchase, possession, and use. Opponents of these legal approaches claim that gun control endangers constitutional freedoms. When asked, the US Supreme court has consistently rejected that position in favor of the view that the Second Amendment protects a collective, not a personal, right to bear arms.3,4


Author(s):  
Andrew Glazzard

‘You will be amused to hear that I am at work upon a Sherlock Holmes story. So the old dog returns to his vomit.’1 Arthur Conan Doyle to Herbert Greenhough Smith Sherlock Holmes, who died in Switzerland in May 1891, returned to the world on 23 October 1899. The location for his rebirth was, somewhat surprisingly, the Star Theatre in Buffalo, New York. Early the following month, Holmes moved to New York where he could be found in Manhattan’s Garrick Theatre on 236 separate occasions, before making his way across the United States. In September 1901, Holmes went back to Great Britain, arriving (like so many travellers from the US) at Liverpool, before reaching London on 9 September 1901. He was so much in demand that on 1 February 1902 he received an audience with King Edward VII and Queen Alexandra. In 1902 he was again in New York, was seen travelling across northern England in 1903, and for the next thirty years popped up repeatedly in various American towns and cities....


Author(s):  
Samuel F. B. Morse

New York City University, September 27, 1837. Dear Sir: In reply to the inquiries which you have done me the honor to make, in asking my opinion ‘of the propriety of establishing a system of telegraphs for the United States,’ I would say, in regard...


Author(s):  
Howard G. Wilshire ◽  
Richard W. Hazlett ◽  
Jane E. Nielson

Since 1900, United States troops have fought in more foreign conflicts than any other nation on Earth. Most Americans supported those actions, believing that they would keep the scourge of war far from our homes. But the strategy seems to have failed—it certainly did not prevent terror attacks against the U.S. mainland. The savage Oklahoma City bombing in 1995 and the 11 September 2001 (9/11) attacks on New York and Washington, D.C. were not the first to inflict war damage in America’s 48 contiguous states, however—nor were they the first warlike actions to harm innocent citizens since the Civil War. Paradoxically, making war abroad has always required practicing warfare in our own back yards. Today’s large, mechanized military training exercises have degraded U.S. soils, water supplies, and wildlife habitats in the same ways that the real wars affected war-torn lands far away. The saddest fact of all is that the deadly components of some weapons in the U.S. arsenal never found use in foreign wars but have attacked U.S. citizens in their own homes and communities. The relatively egalitarian universal service of World War II left a whole generation of Americans with nostalgia and reverence for military service. Many of us, perhaps the majority, might argue that human and environmental sacrifices are the price we must be willing to pay to protect our interests and future security. A current political philosophy proposes that the United States must even start foreign wars to protect Americans and their homes. But Americans are not fully aware of all the past sacrifices—and what we don’t know can hurt us. Even decades-old impacts from military training still degrade land and contaminate air and water, particularly in the arid western states, and will continue to do so far into the future. Exploded and unexploded bombs, mines, and shells (“ordnance,” in military terms) and haphazard disposal sites still litter former training lands in western states. And large portions of the western United States remain playgrounds for war games, subject to large-scale, highly mechanized military operations for maintaining combat readiness and projecting American power abroad.


2019 ◽  
pp. 1-15
Author(s):  
Charlie Laderman

This introductory chapter outlines why the American response to the destruction of the Ottoman Armenians offers such critical insights into the US rise to world power, its evolving relationship with Britain, and the development of ideas on humanitarian intervention and global order at the turn of the twentieth century. It introduces the Armenian question, setting it within the larger Eastern question, and explains why the Ottoman Empire became a target for outside intervention by the European great powers in the nineteenth century. It explains why the United States, which had traditionally avoided political entanglement in the Near East even while its missionaries established an exceptional role there, began to take a greater interest in the region as its emergence as a great power coincided with the first large-scale Armenian massacres.


2020 ◽  
Vol 35 (6) ◽  
pp. 599-603 ◽  
Author(s):  
Colton Margus ◽  
Ritu R. Sarin ◽  
Michael Molloy ◽  
Gregory R. Ciottone

AbstractIntroduction:In 2009, the Institute of Medicine published guidelines for implementation of Crisis Standards of Care (CSC) at the state level in the United States (US). Based in part on the then concern for H1N1 pandemic, there was a recognized need for additional planning at the state level to maintain health system preparedness and conventional care standards when available resources become scarce. Despite the availability of this framework, in the years since and despite repeated large-scale domestic events, implementation remains mixed.Problem:Coronavirus disease 2019 (COVID-19) rejuvenates concern for how health systems can maintain quality care when faced with unrelenting burden. This study seeks to outline which states in the US have developed CSC and which areas of care have thus far been addressed.Methods:An online search was conducted for all 50 states in 2015 and again in 2020. For states without CSC plans online, state officials were contacted by email and phone. Public protocols were reviewed to assess for operational implementation capabilities, specifically highlighting guidance on ventilator use, burn management, sequential organ failure assessment (SOFA) score, pediatric standards, and reliance on influenza planning.Results:Thirty-six states in the US were actively developing (17) or had already developed (19) official CSC guidance. Fourteen states had no publicly acknowledged effort. Eleven of the 17 public plans had updated within five years, with a majority addressing ventilator usage (16/17), influenza planning (14/17), and pediatric care (15/17), but substantially fewer addressing care for burn patients (9/17).Conclusion:Many states lacked publicly available guidance on maintaining standards of care during disasters, and many states with specific care guidelines had not sufficiently addressed the full spectrum of hazard to which their health care systems remain vulnerable.


Author(s):  
Robert Warren ◽  
Donald Kerwin

The Trump administration has made the construction of an “impregnable” 2,000-mile wall across the length of the US-Mexico border a centerpiece of its executive orders on immigration and its broader immigration enforcement strategy. This initiative has been broadly criticized based on: Escalating cost projections: an internal Department of Homeland Security (DHS) study recently set the cost at $21.6 billion over three and a half years; Its necessity given the many other enforcement tools — video surveillance, drones, ground sensors, and radar technologies — and Border Patrol personnel, that cover the US-Mexico border: former DHS Secretary Michael Chertoff and other experts have argued that a wall does not add enforcement value except in heavy crossing areas near towns, highways, or other “vanishing points” (Kerwin 2016); Its cost-effectiveness given diminished Border Patrol apprehensions (to roughly one-fourth the level of historic highs) and reduced illegal entries (to roughly one-tenth the 2005 level according to an internal DHS study) (Martinez 2016); Its efficacy as an enforcement tool: between FY 2010 and FY 2015, the current 654-mile pedestrian wall was breached 9,287 times (GAO 2017, 22); Its inability to meet the administration’s goal of securing “operational control” of the border, defined as “the prevention of all unlawful entries to the United States” (White House 2017); Its deleterious impact on bi-national border communities, the environment, and property rights (Heyman 2013); and Opportunity costs in the form of foregone investments in addressing the conditions that drive large-scale migration, as well as in more effective national security and immigration enforcement strategies. The Center for Migration Studies (CMS) has reported on the dramatic decline in the US undocumented population between 2008 and 2014 (Warren 2016). In addition, a growing percentage of border crossers in recent years have originated in the Northern Triangle states of Central America (CBP 2016). These migrants are fleeing pervasive violence, persecution, and poverty, and a large number do not seek to evade arrest, but present themselves to border officials and request political asylum. Many are de facto refugees, not illegal border crossers. This report speaks to another reason to question the necessity and value of a 2,000-mile wall: It does not reflect the reality of how the large majority of persons now become undocumented. It finds that two-thirds of those who arrived in 2014 did not illegally cross a border, but were admitted (after screening) on non-immigrant (temporary) visas, and then overstayed their period of admission or otherwise violated the terms of their visas. Moreover, this trend in increasing percentages of visa overstays will likely continue into the foreseeable future. The report presents information about the mode of arrival of the undocumented population that resided in the United States in 2014. To simplify the presentation, it divides the 2014 population into two groups: overstays and entries without inspection (EWIs). The term overstay, as used in this paper, refers to undocumented residents who entered the United States with valid temporary visas and subsequently established residence without authorization. The term EWI refers to undocumented residents who entered without proper immigration documents across the southern border. The estimates are based primarily on detailed estimates of the undocumented population in 2014 compiled by CMS and estimates of overstays for 2015 derived by DHS. Major findings include the following: In 2014, about 4.5 million US residents, or 42 percent of the total undocumented population, were overstays. Overstays accounted for about two-thirds (66 percent) of those who arrived (i.e., joined the undocumented population) in 2014. Overstays have exceeded EWIs every year since 2007, and 600,000 more overstays than EWIs have arrived since 2007. Mexico is the leading country for both overstays and EWIs; about one- third of undocumented arrivals from Mexico in 2014 were overstays. California has the largest number of overstays (890,000), followed by New York (520,000), Texas (475,000), and Florida (435,000). Two states had 47 percent of the 6.4 million EWIs in 2014: California (1.7 million) and Texas (1.3 million). The percentage of overstays varies widely by state: more than two-thirds of the undocumented who live in Hawaii, Massachusetts, Connecticut, and Pennsylvania are overstays. By contrast, the undocumented population in Kansas, Arkansas, and New Mexico consists of fewer than 25 percent overstays.  


PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0152327 ◽  
Author(s):  
Debra L. Hanson ◽  
Ruiguang Song ◽  
Silvina Masciotra ◽  
Angela Hernandez ◽  
Trudy L. Dobbs ◽  
...  

2006 ◽  
Vol 39 (2) ◽  
pp. 446-448
Author(s):  
Kim Speers

For Better or Worse: How Political Consultants are Changing Elections in the United States, David Dulio, Albany: State University of New York Press, 2004, pp. xvii, 289.During the 2004 federal election, the media shone light on the political consultants who were reportedly affiliated or somehow related to Paul Martin's election campaign. By their account, the traditional party machine, often viewed to be the primary, if not the only, actor in political campaigns in Canada, seemed to have taken a backseat to the expensive, polished and professional campaign machinery the private sector had to offer. Campaign management through consultancy was now publicly visible in Canada and reliance on the party machine, while still important, seemed to face competition in terms of expertise and proximity to power. However, the study of political campaigns and specifically, the role of political consultants within campaigns, has received sparse attention from the political science community outside of the United States. Yet even in the US, in spite of the prevalent and pervasive presence of political consultants in electoral politics, the study of this group is relatively new.


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