scholarly journals HBV Infection in HIV-Driven Immune Suppression

Viruses ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1077 ◽  
Author(s):  
Loredana Sarmati ◽  
Vincenzo Malagnino
Keyword(s):  
Hbv Infection ◽  
Hiv Positive ◽  
Occult Hbv Infection ◽  
Infected People ◽  
Occult Hbv ◽  
Increased Risk ◽  
B Virus ◽  
Immunodeficiency Virus ◽  
Coinfected Patient ◽  
End Stage

Worldwide, approximately 10% of all human immunodeficiency virus (HIV)-infected people are also chronically coinfected with hepatitis B virus (HBV). HBV infection has a poor prognosis in HIV-positive people and has been documented by an increased risk of developing chronic HBV infection (CHB), progression to liver fibrosis and end-stage liver disease (ESLD) and evolution of hepatocellular carcinoma (HCC). Furthermore, in HIV patients, HBV-resolved infection is often associated with the appearance of HBV-DNA, which configures occult HBV infection (OBI) as a condition to be explored in coinfected patients. In this narrative review we summarize the main aspects of HBV infection in HIV-positive patients, emphasizing the importance of carefully considering the coinfected patient in the context of therapeutic strategies of antiretroviral therapy.

scholarly journals Algorithms for the Testing of Tissue Donors for Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus

2020 ◽  
pp. 1-10
Author(s):  
Axel Pruß ◽  
Akila Chandrasekar ◽  
Jacinto Sánchez-Ibáñez ◽  
Sophie Lucas-Samuel ◽  
Ulrich Kalus ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Tissue Donors ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus ◽  
Immunodeficiency Virus

<b><i>Background:</i></b> Although transmission of pathogenic viruses through human tissue grafts is rare, it is still one of the most serious dreaded risks of transplantation. Therefore, in addition to the detailed medical and social history, a comprehensive serologic and molecular screening of the tissue donors for relevant viral markers for human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) is necessary. In the case of reactive results in particular, clear decisions regarding follow-up testing and the criteria for tissue release must be made. <b><i>Methods:</i></b> Based on the clinical relevance of the specific virus markers, the sensitivity of the serological and molecular biological methods used and the application of inactivation methods, algorithms for tissue release are suggested. <b><i>Results:</i></b> Compliance with the preanalytical requirements and assessment of a possible hemodilution are mandatory requirements before testing the blood samples. While HIV testing follows defined algorithms, the procedures for HBV and HCV diagnostics are under discussion. Screening and decisions for HBV are often not as simple, e.g., due to cases of occult HBV infection, false-positive anti-HBc results, or early window period positive HBV NAT results. In the case of HCV diagnostics, modern therapies with direct-acting antivirals, which are often associated with successful treatment of the infection, should be included in the decision. <b><i>Conclusion:</i></b> In HBV and HCV testing, a high-sensitivity virus genome test should play a central role in diagnostics, especially in the case of equivocal serology, and it should be the basis for the decision to release the tissue. The proposed test algorithms and decisions are also based on current European recommendations and standards for safety and quality assurance in tissue and cell banking.

A new method of concentrating hepatitis B virus (HBV) DNA and HBV surface antigen: an application of the method to the detection of occult HBV infection

Vox Sanguinis ◽  
2008 ◽  
Vol 95 (3) ◽  
pp. 174-180 ◽  
Author(s):  
K. Satoh ◽  
A. Iwata-Takakura ◽  
A. Yoshikawa ◽  
Y. Gotanda ◽  
T. Tanaka ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hbv Dna ◽  
Hbv Infection ◽  
New Method ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus

scholarly journals Hepatitis B virus genotype, HBsAg mutations and co-infection with HCV in occult HBV infection

2011 ◽  
Vol 35 (8-9) ◽  
pp. 554-559 ◽  
Author(s):  
M.K. Arababadi ◽  
A.A. Pourfathollah ◽  
A. Jafarzadeh ◽  
G. Hassanshahi ◽  
M. Salehi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
Virus Genotype ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus

scholarly journals Prevalence of Hepatitis B Virus Infection in Healthy Thai People after Implementation of the Expanded Program on Immunization

2016 ◽  
Vol 35 (2) ◽  
pp. 47
Author(s):  
Somying Ngamurulert ◽  
Isaya Janwithayanuchit ◽  
Sumonrat Chuwongwattana ◽  
Suda Louisirirotchanakul ◽  
Prasert Auewarakul
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
First Year ◽  
Nested Polymerase Chain Reaction ◽  
Occult Hbv Infection ◽  
First Year Students ◽  
Occult Hbv ◽  
B Virus ◽  
Expanded Program On Immunization

Objective: To investigate the prevalence of hepatitis B virus (HBV) infection and to diagnose an occult HBV infection in healthy Thai subjects after implementation of the expanded program on immunization (EPI) in newborns.Material and Method: The detection of HBsAg, anti-HBs and anti-HBc was done from serum samples of 5,886 healthy first year students from Huachiew Chalermprakiet University collected between 2009-2011 by immunochro-matography rapid assay (Alcon, USA). In case of only anti-HBc positive, the results were confirmed with chemiluminescence enzyme immunoassay (EIA) method and then they were investigated further for HBV occult infection by nested polymerase chain reaction technique.Results: A total of 78% (4,593/5,886) healthy first year students who had been vaccinated with HBV vaccine since birth were found to have no HBV markers, while 18.4% (1,083/5,886) had only anti-HBs. The prevalence of infection was 3.6% (210/5,886). Identification of patterns of HBV infection among the 210 infected subjects found that (1) Immuned due to past infection was 61.9% (130/210) (2) Infected with hepatitis B virus was 38.1% (80/120). The prevalence of both HBsAg and anti-HBc was 28.6% (60/210), while the prevalences of HBsAg and Anti-HBc alone were 3.8% (8/210) and 5.7% (12/210), respectively. Anti-HBc alone group was repeated with chemiluminescence EIA and HBV DNA was negative.Conclusion: The prevalence of HBV infection was 3.6% (210/5,886), however, seropositive rate of HBV infection was 1.4% (80/5,886). Most antibodies from vaccination had substantially declined to the point that it was undetectable. Therefore, the overall study showed an effective implementation of EPI in newborns. 

scholarly journals Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) Can Coinfect the Same Hepatocyte in the Liver of Patients with Chronic HCV and Occult HBV Infection

2005 ◽  
Vol 79 (24) ◽  
pp. 15578-15581 ◽  
Author(s):  
E. Rodríguez-Íñigo ◽  
J. Bartolomé ◽  
N. Ortiz-Movilla ◽  
C. Platero ◽  
J. M. López-Alcorocho ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus ◽  
Chronic Hcv ◽  
In Cells

ABSTRACT In this work, we have shown that hepatitis C virus (HCV) and hepatitis B virus (HBV) can coexist in the same hepatocyte using double fluorescent in situ hybridization in liver biopsy samples from patients with chronic HCV infection with occult HBV infection. Digital image analysis of hybridization signals showed that the HBV DNA levels in coinfected hepatocytes were lower than those in cells infected only with HBV. This finding supports the hypothesis of inhibition of HBV replication by HCV. Furthermore, HCV RNA levels were lower in coinfected cells than in cells infected only with HCV, suggesting that HBV may also inhibit HCV replication.

Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection

2004 ◽  
Vol 126 (1) ◽  
pp. 102-110 ◽  
Author(s):  
Teresa Pollicino ◽  
Giovanni Squadrito ◽  
Giovanni Cerenzia ◽  
Irene Cacciola ◽  
Giuseppina Raffa ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus

scholarly journals PP-110 Detecting hepatitis B virus large surface protein to filtrate the occult HBV infection

2009 ◽  
Vol 13 ◽  
pp. S78
Author(s):  
Zheng-lin Wu ◽  
Jian Liu ◽  
Xiao-qiang Zhong ◽  
Guang-cheng Lin ◽  
Xue-dong Lu
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Protein ◽  
Hbv Infection ◽  
Occult Hbv Infection ◽  
Occult Hbv ◽  
B Virus
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