scholarly journals Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines

Viruses ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 434
Author(s):  
Seyedeh Raheleh Niavarani ◽  
Christine Lawson ◽  
Lee-Hwa Tai
Keyword(s):  
Infected Cell ◽  
Natural Killer ◽  
Tumor Antigens ◽  
Critical Role ◽  
Killer Cell ◽  
Oncolytic Viruses ◽  
Cell Vaccine ◽  
Tumor Killing

Oncolytic viruses (OVs) are a form of immunotherapy that release tumor antigens in the context of highly immunogenic viral signals following tumor-targeted infection and destruction. Emerging preclinical and clinical evidence suggests that this in situ vaccine effect is critical for successful viro-immunotherapy. In this review, we discuss the application of OV as an infected cell vaccine (ICV) as one method of enhancing the potency and breadth of anti-tumoral immunity. We focus on understanding and manipulating the critical role of natural killer (NK) cells and their interactions with other immune cells to promote a clinical outcome. With a synergistic tumor killing and immune activating mechanism, ICVs represent a valuable new addition to the cancer fighting toolbox with the potential to treat malignant disease.

scholarly journals Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Cell Reports ◽  
2016 ◽  
Vol 15 (5) ◽  
pp. 1088-1099 ◽  
Author(s):  
Lisa L. Liu ◽  
Johannes Landskron ◽  
Eivind H. Ask ◽  
Monika Enqvist ◽  
Ebba Sohlberg ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Critical Role ◽  
Killer Cell ◽  
Cell Responses

scholarly journals The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity

2013 ◽  
Vol 4 ◽  
Author(s):  
Joanna Baginska ◽  
Elodie Viry ◽  
Jérôme Paggetti ◽  
Sandrine Medves ◽  
Guy Berchem ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Tumor Immunity ◽  
Critical Role ◽  
Killer Cell

Molecular modulation of calcium oxalate crystallization

2006 ◽  
Vol 291 (6) ◽  
pp. F1123-F1132 ◽  
Author(s):  
James J. De Yoreo ◽  
S. Roger Qiu ◽  
John R. Hoyer
Keyword(s):  
Molecular Modeling ◽  
Calcium Oxalate ◽  
Stone Formation ◽  
Energy Levels ◽  
Critical Role ◽  
Specific Interactions ◽  
Crystal Surfaces ◽  
Site Specific

Calcium oxalate monohydrate (COM) is the primary constituent of the majority of renal stones. Osteopontin (OPN), an aspartic acid-rich urinary protein, and citrate, a much smaller molecule, are potent inhibitors of COM crystallization at levels present in normal urine. Current concepts of the role of site-specific interactions in crystallization derived from studies of biomineralization are reviewed to provide a context for understanding modulation of COM growth at a molecular level. Results from in situ atomic force microscopy (AFM) analyses of the effects of citrate and OPN on growth verified the critical role of site-specific interactions between these growth modulators and individual steps on COM crystal surfaces. Molecular modeling investigations of interactions of citrate with steps and faces on COM crystal surfaces provided links between the stereochemistry of interaction and the binding energy levels that underlie mechanisms of growth modification and changes in overall crystal morphology. The combination of in situ AFM and molecular modeling provides new knowledge that will aid rationale design of therapeutic agents for inhibition of stone formation.

Role of Adhesion Molecules in Natural Killer Cell-Induced DNA Fragmentation of Cytomegalovirus-Infected Fibroblasts

1996 ◽  
Vol 9 (4) ◽  
pp. 219-224 ◽  
Author(s):  
MASAHIRO ITO ◽  
MASAHIRO WATANABE ◽  
HITOSHI KAMIYA ◽  
MINORU SAKURAI
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Adhesion Molecules ◽  
Dna Fragmentation ◽  
Killer Cell

Inhibition of Lung Natural Killer Cell Activity by Smoking: The Role of Alveolar Macrophages

Respiration ◽  
2001 ◽  
Vol 68 (3) ◽  
pp. 262-267 ◽  
Author(s):  
M. Takeuchi ◽  
S. Nagai ◽  
A. Nakajima ◽  
M. Shinya ◽  
C. Tsukano ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Alveolar Macrophages ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Killer Cell Activity

scholarly journals Role of HLA in Hematopoietic Stem Cell Transplantation

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Meerim Park ◽  
Jong Jin Seo
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Critical Role ◽  
Killer Cell ◽  
Human Leukocyte ◽  
Hematopoietic Stem

The selection of hematopoietic stem cell transplantation (HSCT) donors includes a rigorous assessment of the availability and human leukocyte antigen (HLA) match status of donors. HLA plays a critical role in HSCT, but its involvement in HSCT is constantly in flux because of changing technologies and variations in clinical transplantation results. The increased availability of HSCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of killer-cell immunoglobulin-like receptor (KIR) genes in HSCT. The influence of nongenetic factors on the tolerability of HLA mismatching has recently become evident, demonstrating a need for the integration of both genetic and nongenetic variables in donor selection.

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