scholarly journals Manipulation of Epithelial Differentiation by HPV Oncoproteins

Viruses ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 369 ◽  
Author(s):  
Elizabeth A. White
Keyword(s):  
Hpv Infection ◽  
Epithelial Differentiation ◽  
Inhibitory Mechanisms ◽  
Open Questions ◽  
Key Features ◽  
E6 And E7 Oncoproteins ◽  
E6 And E7 ◽  
Hpv Oncoproteins ◽  
The Relationship ◽  
Do So

Papillomaviruses replicate and cause disease in stratified squamous epithelia. Epithelial differentiation is essential for the progression of papillomavirus replication, but differentiation is also impaired by papillomavirus-encoded proteins. The papillomavirus E6 and E7 oncoproteins partially inhibit and/or delay epithelial differentiation and some of the mechanisms by which they do so are beginning to be defined. This review will outline the key features of the relationship between HPV infection and differentiation and will summarize the data indicating that papillomaviruses alter epithelial differentiation. It will describe what is known so far and will highlight open questions about the differentiation-inhibitory mechanisms employed by the papillomaviruses.

scholarly journals Novel Antigenic Targets of HPV Therapeutic Vaccines

Vaccines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1262
Author(s):  
Ditte Rahbæk Boilesen ◽  
Karen Nørgaard Nielsen ◽  
Peter Johannes Holst
Keyword(s):  
Cervical Cancer ◽  
Head And Neck ◽  
Cytotoxic T Cells ◽  
Expression Patterns ◽  
Hpv Infection ◽  
Therapeutic Vaccines ◽  
Screening Programs ◽  
Associated Lesions ◽  
E6 And E7 ◽  
Hpv Oncoproteins

Human papillomavirus (HPV) infection is the cause of the majority of cervical cancers and head and neck cancers worldwide. Although prophylactic vaccines and cervical cancer screening programs have shown efficacy in preventing HPV-associated cervical cancer, cervical cancer is still a major cause of morbidity and mortality, especially in third world countries. Furthermore, head and neck cancer cases caused by HPV infection and associated mortality are increasing. The need for better therapy is clear, and therapeutic vaccination generating cytotoxic T cells against HPV proteins is a promising strategy. This review covers the current scene of HPV therapeutic vaccines in clinical development and discusses relevant considerations for the design of future HPV therapeutic vaccines and clinical trials, such as HPV protein expression patterns, immunogenicity, and exhaustion in relation to the different stages and types of HPV-associated lesions and cancers. Ultimately, while the majority of the HPV therapeutic vaccines currently in clinical testing target the two HPV oncoproteins E6 and E7, we suggest that there is a need to include more HPV antigens in future HPV therapeutic vaccines to increase efficacy and find that especially E1 and E2 could be promising novel targets.

scholarly journals Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins

2019 ◽  
Vol 24 (10) ◽  
pp. 2044-2057 ◽  
Author(s):  
Ana M. Almeida ◽  
João A. Queiroz ◽  
Fani Sousa ◽  
Ângela Sousa
Keyword(s):  
Cervical Cancer ◽  
Hpv Infection ◽  
E6 And E7 Oncoproteins ◽  
E6 And E7 ◽  
Therapeutic Research

scholarly journals Dialogic Discourse Analysis: A methodology for dealing with the classroom as a text

2019 ◽  
Vol 7 ◽  
Author(s):  
Atle Skaftun
Keyword(s):  
Discourse Analysis ◽  
Educational Research ◽  
Main Part ◽  
Educational Settings ◽  
Dialogic Discourse ◽  
Ongoing Work ◽  
Key Features ◽  
The Relationship ◽  
Analytical Practice ◽  
Do So

Bakhtin is a source of theoretical inspiration for educational research. This article will be an attempt to activate also Bakhtin’s analytical practice and his methodology. I will explore and elaborate the typology of discursive relations which are suggested in Bakhtin’s book on Problems of Dostoevsky’ Poetics (Bakhtin ,1984), and the potential application of it in the study of discourse in the classroom. In order to do so properly it will be necessary to activate Bakhtin’s understanding of the utterance as a meaningful unity, and thus also the problem of authorship and the relationship between author and hero.Bakhtin’s analytical practice can be considered a consistent methodology for the study of literature in schools as well as in the scholarly study of literature (cf. Skaftun, 2009; 2010), and I have called it dialogic discourse analysis (DDA). The first main part of the article elaborates key features of DDA in dialogue with Bakhtin’s work. In the other main part, DDA is applied to educational settings in order to enter the educational dialogue on how to make sense of authorship and the adhering conception of the classroom as a text. My ambition here is primarily to elaborate DDA as a powerful and dynamic toolkit also for educational research. In doing so I also hope to contribute to the ongoing work of transferring Bakhtin’s dialogism as a whole from the study of literature to the study of education. Examples will in part be drawn from literature, but for the most part from educational settings.

scholarly journals HPV Oncoproteins and the Ubiquitin Proteasome System: A Signature of Malignancy?

Pathogens ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 133 ◽  
Author(s):  
Anamaria Đukić ◽  
Lucija Lulić ◽  
Miranda Thomas ◽  
Josipa Skelin ◽  
Nathaniel Edward Bennett Saidu ◽  
...  
Keyword(s):  
Ubiquitin Proteasome System ◽  
Cellular Functions ◽  
Hpv E6 ◽  
System A ◽  
Ubiquitin Proteasome ◽  
Cellular Pathways ◽  
E6 And E7 Oncoproteins ◽  
E6 And E7 ◽  
Hpv Oncoproteins ◽  
Regulation Of Cell Cycle

Human papillomavirus (HPV) E6 and E7 oncoproteins are critical for development and maintenance of the malignant phenotype in HPV-induced cancers. These two viral oncoproteins interfere with a plethora of cellular pathways, including the regulation of cell cycle and the control of apoptosis, which are critical in maintaining normal cellular functions. E6 and E7 bind directly with certain components of the Ubiquitin Proteasome System (UPS), enabling them to manipulate a number of important cellular pathways. These activities are the means by which HPV establishes an environment supporting the normal viral life cycle, however in some instances they can also lead to the development of malignancy. In this review, we have discussed how E6 and E7 oncoproteins from alpha and beta HPV types interact with the components of the UPS, and how this interplay contributes to the development of cancer.

A combined ultrastructural and gene molecular research for the relationship between human uterine cervical carcinoma and human papillomavirus

1990 ◽  
Vol 48 (3) ◽  
pp. 204-205
Author(s):  
Kun Lee ◽  
Jingyi Si ◽  
Ricai Han ◽  
Wei Zhang ◽  
Bingbing Tan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Dot Blot ◽  
Homologous Sequences ◽  
Normal Cervical Epithelium ◽  
The Relationship ◽  
Chronic Cervicitis

There are more supports for the view that human papillomavirus (HPV) infection might be an etiological factor in the development of cervical cancer when the association of persistent condylomata is considered. Biopsies from 318 cases with squamous cell carcinoma of uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 normal cervical epithelium were collected from 5 geographic regions of China with different cervical cancer mortalities. All specimens were prepared for Dot blot, Southern blot and in situ DNA-DNA hybridizations by using HPV-11, 16, 18 DNA labelled with 32P and 3H as probes to detect viral homologous sequences in samples. Among them, 32 cases with cervical cancer, 27 with condyloma and 10 normal cervical epitheliums were randomly chosen for comparative EM observation. The results showed that: 1), 192 out of 318 (60.4%) cases of cervical cancer were positive for HPV-16 DNA probe (Table I)

Home, Sweet Home: Negotiating Intimacy in Brazilian Elitist Closed Condominiums

2020 ◽  
Vol 9 (1) ◽  
pp. 374-395
Author(s):  
Rafael Ignacio Estrada Mejia ◽  
Carla Guerrón Guerron Montero
Keyword(s):  
Collective Mode ◽  
Living Arrangement ◽  
Public Life ◽  
Ethnographic Research ◽  
Social Distinction ◽  
History Of ◽  
Collective Production ◽  
The Relationship ◽  
Do So

This article aims to decrease the cultural invisibility of the wealthy by exploring the Brazilian emergent elites and their preferred living arrangement: elitist closed condominiums (BECCs) from a micropolitical perspective.  We answer the question: What is the relationship between intimacy and subjectivity that is produced in the collective mode of existence of BECCs? To do so, we trace the history of the elite home, from the master’s house (casa grande) to contemporary closed condominiums. Following, we discuss the features of closed condominiums as spaces of segregation, fragmentation and social distinction, characterized by minimal public life and an internalized sociability. Finally, based on ethnographic research conducted in the mid-size city of Londrina (state of Paraná) between 2015 and 2017, we concentrate on four members of the emergent elite who live in BECCs, addressing their collective production of subjectivity. 

E6 and E7 oncoproteins: Potential targets of cervical cancer

2020 ◽  
Vol 27 ◽  
Author(s):  
Ramarao Malla ◽  
Mohammad Amjad Kamal
Keyword(s):  
Cervical Cancer ◽  
Drug Resistance ◽  
Host Cell ◽  
Molecular Mechanisms ◽  
Immune Therapy ◽  
Cervical Lesions ◽  
Diagnostic Strategies ◽  
E6 And E7 Oncoproteins ◽  
E6 And E7

: Cervical cancer (CC) is the fourth leading cancer in women in the age group 15-44 globally. Experimental as well as epidemiological studies identified that type16 and 18 HPV cause 70% of precancerous cervical lesions as well as cervical cancer worldwide by bringing about genetic as well as epigenetic changes in the host genome. The insertion of the HPV genome triggers various defense mechanisms including the silencing of tumor suppressor genes as well as activation of oncogenes associated with cancer metastatic pathway. E6 and E7 are small oncoproteins consisting of 150 and 100 amino acids respectively. These oncoproteins affect the regulation of the host cell cycle by interfering with p53 and pRb. Further these oncoproteins adversely affect the normal functions of the host cell by binding to their signaling proteins. Recent studies demonstrated that E6 and E7 oncoproteins are potential targets for CC. Therefore, this review discusses the role of E6 and E7 oncoproteins in metastasis and drug resistance as well as their regulation, early oncogene mediated signaling pathways. This review also uncovers the recent updates on molecular mechanisms of E6 and E7 mediated phytotherapy, gene therapy, immune therapy, and vaccine strategies as well as diagnosis through precision testing. Therefore, understanding the potential role of E6/E7 in metastasis and drug resistance along with targeted treatment, vaccine, and precision diagnostic strategies could be useful for the prevention and treatment of cervical cancer.

Public Powers, Private Powers, and the Exploitation of Metals for Coinage

2018 ◽  
Author(s):  
Giovanna Bianchi
Keyword(s):  
Middle Ages ◽  
Field Research ◽  
Mineral Resources ◽  
Medieval Period ◽  
Early Medieval ◽  
Early Medieval Period ◽  
Italian Journal ◽  
Open Questions ◽  
And Control ◽  
The Relationship

In 1994, an article appeared in the Italian journal Archeologia Medievale, written by Chris Wickham and Riccardo Francovich, entitled ‘Uno scavo archeologico ed il problema dello sviluppo della signoria territoriale: Rocca San Silvestro e i rapporti di produzione minerari’. It marked a breakthrough in the study of the exploitation of mineral resources (especially silver) in relation to forms of power, and the associated economic structure, and control of production between the twelfth and thirteenth centuries. On the basis of the data available to archeological research at the time, the article ended with a series of open questions, especially relating to the early medieval period. The new campaign of field research, focused on the mining landscape of the Colline Metallifere in southern Tuscany, has made it possible to gather more information. While the data that has now been gathered are not yet sufficient to give definite and complete answers to those questions, they nevertheless allow us to now formulate some hypotheses which may serve as the foundations for broader considerations as regards the relationship between the exploitation of a fundamental resource for the economy of the time, and the main players and agents in that system of exploitation, within a landscape that was undergoing transformation in the period between the early medieval period and the middle centuries of the Middle Ages.

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