scholarly journals Hepatitis E virus (HEV)—The Future

Viruses ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 251 ◽  
Author(s):  
Joachim Denner
Keyword(s):  
De Novo ◽  
Hepatitis E ◽  
Pork Production ◽  
Counter Measures ◽  
Health Concept ◽  
Contaminated Food ◽  
The One ◽  
Vegetables And Fruits ◽  
Acute And Chronic Hepatitis ◽  
Sensitive Testing

Hepatitis (HEV) is widely distributed in pigs and is transmitted with increasing numbers to humans by contact with pigs, contaminated food and blood transfusion. The virus is mostly apathogenic in pigs but may enhance the pathogenicity of other pig viruses. In humans, infection can lead to acute and chronic hepatitis and extrahepatic manifestations. In order to stop the emerging infection, effective counter-measures are required. First of all, transmission by blood products can be prevented by screening all blood donations. Meat and sausages should be appropriately cooked. Elimination of the virus from the entire pork production can be achieved by sensitive testing and elimination programs including early weaning, colostrum deprivation, Caesarean delivery, embryo transfer, treatment with antivirals, protection from de novo infection, and possibly vaccination. In addition, contaminated water, shellfish, vegetables, and fruits by HEV-contaminated manure should be avoided. A special situation is given in xenotransplantation using pig cells, tissues or organs in order to alleviate the lack of human transplants. The elimination of HEV from pigs, other animals and humans is consistent with the One Health concept, preventing subclinical infections in the animals as well as preventing transmission to humans and disease.

The “one health”-concept and organic production of vegetables and fruits

2019 ◽  
pp. 1-14
Author(s):  
B.W. Alsanius ◽  
E. von Essen ◽  
R. Hartmann ◽  
I. Vågsholm ◽  
O. Doyle ◽  
...  
Keyword(s):  
One Health ◽  
Organic Production ◽  
Health Concept ◽  
The One ◽  
Vegetables And Fruits

scholarly journals Epidemiology of hepatitis E in South-East Europe in the "One Health" concept

2019 ◽  
Vol 25 (25) ◽  
pp. 3168-3182 ◽  
Author(s):  
Anna Mrzljak ◽  
Petra Dinjar-Kujundzic ◽  
Lorena Jemersic ◽  
Jelena Prpic ◽  
Ljubo Barbic ◽  
...  
Keyword(s):  
One Health ◽  
Hepatitis E ◽  
East Europe ◽  
South East Europe ◽  
Health Concept ◽  
The One

scholarly journals General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shay Laps ◽  
Fatima Atamleh ◽  
Guy Kamnesky ◽  
Hao Sun ◽  
Ashraf Brik
Keyword(s):  
Drug Discovery ◽  
Disulfide Bonds ◽  
Unsolved Problem ◽  
De Novo ◽  
Therapeutic Potential ◽  
Selective Activation ◽  
One Pot ◽  
Synthetic Strategy ◽  
The One ◽  
Game Changer

AbstractDespite six decades of efforts to synthesize peptides and proteins bearing multiple disulfide bonds, this synthetic challenge remains an unsolved problem in most targets (e.g., knotted mini proteins). Here we show a de novo general synthetic strategy for the ultrafast, high-yielding formation of two and three disulfide bonds in peptides and proteins. We develop an approach based on the combination of a small molecule, ultraviolet-light, and palladium for chemo- and regio-selective activation of cysteine, which enables the one-pot formation of multiple disulfide bonds in various peptides and proteins. We prepare bioactive targets of high therapeutic potential, including conotoxin, RANTES, EETI-II, and plectasin peptides and the linaclotide drug. We anticipate that this strategy will be a game-changer in preparing millions of inaccessible targets for drug discovery.

scholarly journals P037 DMARDs & hepatitis E: the hidden culprit

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Geraint A Brown ◽  
Louise Kearney ◽  
Elizabeth Warner ◽  
Spencer Ellis
Keyword(s):  
Rheumatoid Arthritis ◽  
Liver Function ◽  
Liver Function Tests ◽  
Hepatitis E ◽  
British Society ◽  
Good Effect ◽  
Solid Organ ◽  
Seropositive Rheumatoid Arthritis ◽  
Function Tests ◽  
Contaminated Food

Abstract Background/Aims  Disease-modifying anti-rheumatic drugs (DMARDs) require blood monitoring as recommended by the British Society for Rheumatology guidelines. Deranged liver function tests are a common abnormality, and when a significant transaminitis occurs further investigations are required. We wish to present three cases where a transaminitis was caused by acute hepatitis E. Hepatitis E rarely causes illness in the general population. Transmission can occur via sewage-contaminated food and water, undercooked or raw pig and game meat, or processed pork and shellfish. Blood transfusion and solid organ transplantation is very rare. There is an estimated 60,000 cases of Hepatitis E per year in England. Those who are immunosuppressed are more likely to develop chronic liver disease. Methods  . Results  Case 1 is 55 year old male with a seronegative inflammatory arthritis treated with methotrexate and sulfasalazine whose ALT rose to 2043 U/l. After a negative liver screen including autoantibodies, Hepatitis E IgM was detected. Case 2 is a 71 year old male with seropositive rheumatoid arthritis prescribed Methotrexate and Sulfasalazine who developed a transaminitis following a holiday to Spain. Hepatitis E serology was positive. Case 3 is a 65 year old male with seropositive rheumatoid arthritis on Abatacept and Methotrexate who also developed deranged liver function tests following a trip to Spain. Alcohol excess was initially suspected due to the consumption of > 20 units per week. However, on cessation of all medications the ALT continued to rise to 1087 U/l. He was found to be Hepatitis E IgM positive with viral PCR also detected. In all three cases contaminated food was likely to be the source of infection and DMARDs were successfully restarted in all patients following normalisation of liver function tests. Conclusion  This case series highlights an important differential for transaminitis with very little published literature. Hepatitis E is under reported and not routinely requested in practice as part of a liver screen. Failure to check Hepatitis E serology may lead to DMARDs being discontinued inappropriately. All patients should be educated about the risks of Hepatitis E from food products.We recommend that DMARDs are suspended once Hepatitis E infection has been diagnosed in order to allow the immune system combat the infection. Treatment is usually self limiting, though in severe cases Ribavirin has been used with good effect. DMARDs should be restarted once liver markers normalise, and two serum Hepatitis E RNA results and two stool samples are negative. The presence of persistent Hepatitis E RNA (viral shedding) is highly suspicious for chronic infection, which would warrant hepatology input. Disclosure  G.A. Brown: None. L. Kearney: None. E. Warner: None. S. Ellis: None.

scholarly journals Tick-borne zoonoses and commonly used diagnostic methods in human and veterinary medicine

2021 ◽  
Author(s):  
Andrea Springer ◽  
Antje Glass ◽  
Julia Probst ◽  
Christina Strube
Keyword(s):  
Veterinary Medicine ◽  
Diagnostic Tests ◽  
One Health ◽  
Animal Health ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Diagnostic Tools ◽  
Zoonotic Pathogens ◽  
Health Concept ◽  
The One

AbstractAround the world, human health and animal health are closely linked in terms of the One Health concept by ticks acting as vectors for zoonotic pathogens. Animals do not only maintain tick cycles but can either be clinically affected by the same tick-borne pathogens as humans and/or play a role as reservoirs or sentinel pathogen hosts. However, the relevance of different tick-borne diseases (TBDs) may vary in human vs. veterinary medicine, which is consequently reflected by the availability of human vs. veterinary diagnostic tests. Yet, as TBDs gain importance in both fields and rare zoonotic pathogens, such as Babesia spp., are increasingly identified as causes of human disease, a One Health approach regarding development of new diagnostic tools may lead to synergistic benefits. This review gives an overview on zoonotic protozoan, bacterial and viral tick-borne pathogens worldwide, discusses commonly used diagnostic techniques for TBDs, and compares commercial availability of diagnostic tests for humans vs. domestic animals, using Germany as an example, with the aim of highlighting existing gaps and opportunities for collaboration in a One Health framework.

scholarly journals Hepatitis E Virus in Croatia in the “One-Health” Context

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 699
Author(s):  
Anna Mrzljak ◽  
Lorena Jemersic ◽  
Vladimir Savic ◽  
Ivan Balen ◽  
Maja Ilic ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Current Knowledge ◽  
Hepatitis E ◽  
Human Case ◽  
Interspecies Transmission ◽  
Genotype 3 ◽  
Chronic Patients ◽  
Indirect Contact ◽  
The One ◽  
Foodborne Infection

Hepatitis E virus (HEV) is the most common cause of viral hepatitis globally. The first human case of autochthonous HEV infection in Croatia was reported in 2012, with the undefined zoonotic transmission of HEV genotype 3. This narrative review comprehensively addresses the current knowledge on the HEV epidemiology in humans and animals in Croatia. Published studies showed the presence of HEV antibodies in different population groups, such as chronic patients, healthcare professionals, voluntary blood donors and professionally exposed and pregnant women. The highest seroprevalence in humans was found in patients on hemodialysis in a study conducted in 2018 (27.9%). Apart from humans, different studies have confirmed the infection in pigs, wild boars and a mouse, indicating the interspecies transmission of HEV due to direct or indirect contact or as a foodborne infection. Continued periodical surveys in humans and animals are needed to identify the possible changes in the epidemiology of HEV infections.

One Health in South Asia and its challenges in implementation from stakeholder perspective

2017 ◽  
Vol 181 (23) ◽  
pp. 626-626 ◽  
Author(s):  
Rojan Dahal ◽  
Atul Upadhyay ◽  
Benjamin Ewald
Keyword(s):  
South Asia ◽  
One Health ◽  
Animal Health ◽  
Grey Literature ◽  
Government Support ◽  
Health Concept ◽  
The Government ◽  
The One ◽  
Considerable Work ◽  
Google Search

One Health is a concept which fosters collaborative relationships between human health, animal health and environmental health partners. Diseases are emerging and re-emerging in South Asia due to poor sanitation, close proximity of people to livestock, deforestation, porous borders, climate change, changes in human behaviour and unhygienic food preparation and consumption practices. This review was completed in two stages. First, we conducted a review of peer-reviewed literature and grey literature available in Google search engine related to One Health in four countries (Bangladesh, Bhutan, India and Nepal). Second, we used a structured questionnaire completed by the key stakeholders working on One Health for the collection of information related to the challenges in implementing One Health. Most of the One Health activities in South Asia are determined by donor preferences. Bangladesh and India did considerable work in advancing One Health with limited support from the government agencies. Weak surveillance mechanisms, uncertain cost-effectiveness of One Health compared with the existing approach, human resources and laboratory capacity are some of the factors hindering implementation of the One Health concept. Implementation of One Health is growing in the South Asia region with limited or no government acceptance. To institutionalise it, there is a need for leadership, government support and funding.

Divisional morphogenesis in the marine ciliate Holosticha warreni (Ciliophora: Hypotrichida)

2000 ◽  
Vol 80 (5) ◽  
pp. 785-788 ◽  
Author(s):  
Xiaozhong Hu ◽  
Weibo Song ◽  
Alan Warren
Keyword(s):  
Coastal Waters ◽  
De Novo ◽  
Cortical Development ◽  
Impregnation Method ◽  
Marine Ciliate ◽  
Group Type ◽  
Generation Mode ◽  
The One

The cortical development of the marine hypotrichous ciliate Holosticha warreni, found in coastal waters near Qingdao, China, was investigated using the protargol impregnation method. In the proter, disorganization of the parental adoral zone of membranelles and undulating membranes contributes to the formation of its oral primordia which replace the parental buccal apparatus completely. Cirral anlagen in both division parts derive from the breaking of primary primordia. Most midventral cirri join in the formation of these primordia which occurs de novo separately from the oral primordia. Each of the 11 to 13 oblique streaks divides into three segments (new cirri) while the last two anlagen produce four each. Two frontoterminal cirri derive from the posteriormost anlage. The marginal rows develop from the parental structure. The generation mode of dorsal kineties is of the ‘one group type’ without forming caudal cirri.

Multicentre Study of Endo-Ectoparasite Infection in Italian Cats

2021 ◽  
Author(s):  
Marco Genchi ◽  
ALICE VISMARRA ◽  
STEFANIA ZANET ◽  
SIMONE MORELLI ◽  
ROBERTA GALUPPI ◽  
...  
Keyword(s):  
Risk Factors ◽  
Geographic Area ◽  
Human Infection ◽  
Diagnostic Methods ◽  
Effective Control ◽  
Entire Study ◽  
Private Households ◽  
Health Concept ◽  
Study Population ◽  
The One

Abstract BackgroundParasites infecting cats include protozoa, helminths and arthropods. Many are also transmissible to humans. Effective control relies on knowledge of parasite distribution and risk factors for infection. The present study was aimed at evaluating prevalence of major feline parasites in Italy and risk factors associated with their occurrence.MethodsOver a 12-month study period, thirteen study centers across Italy analyzed feces, hair and ectoparasites from naturally infected cats coming from feral colonies, shelters and private households. Samples from cats (n=987) were analyzed by all centers using the same diagnostic methods. Prevalence values and risk factors were evaluated statistically for identification of predictors of risk. ResultsThe overall prevalence of gastro-intestinal (GI) and bronco-pulmonary (BP) nematodes was 35.9% (354/987). T. cati was the most prevalent species (253/987; 25.6%), followed by hookworms (98/987; 9.9%). Among BP nematodes, A. abstrusus was the most common (76/987; 7.7%). Approximately 35.7% (352/987) of the study population was infested by ectoparasites. The most common were fleas 29.4% (290/987), followed by ear mites O. cynotis 9.8% (97/987).Predictors of risk for parasite infection included age, a predominantly or exclusively outdoor lifestyle, geographic area and lack of anti-parasitic treatment.ConclusionBoth ecto- and endoparasites are still common in cats throughout Italy, many of them being of zoonotic concern and vectors of pathogens to humans. Given the presence of parasites throughout the entire study period, year-round treatment should be considered. Furthermore, data confirm the need to protect the human-animal bond using proper endo- and ecto-parasiticides to reduce the risk of human infection, in application of the One-Health concept.

Medical interns’ attitudes towards One Health approach

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ceren Varer Akpinar ◽  
Seyfi Durmaz
Keyword(s):  
One Health ◽  
Health And Safety ◽  
Cross Sectional Study ◽  
Study Data ◽  
Self Report ◽  
Related Factors ◽  
Cross Sectional ◽  
Health Concept ◽  
Medical Interns ◽  
The One

Abstract Objectives One Health approach to health considers human, animal, and ecosystem health as a whole and advocates cooperation across disciplines to reach the highest level of health. The aim of the study is to determine the attitudes of the medical interns’ toward the One Health approach and to evaluate related factors. Methods This cross-sectional study targeted all interns of the Faculty of Medicine of 2019–2020 academic year (n=356). Sociodemographic characteristics, health status, habits, and attitudes toward One Health were asked in the questionnaire, which was created by the researchers using the literature. The study data were collected based on self-report during occupational health and safety training, before the COVID-19 pandemic. Chi-square and logistic regression analyses were also performed. Results The study group included a fair gender distribution (47.8% female), and the average age was 23.6 ± 1.2. Out of the 316 participants, 40.2% had not heard the One Health concept before. In total, 85.4% of them declared a positive attitude toward the concept. The probability of high attitude was found to be 5.03 times (95% CI 1.10–23.12) higher in those with above-average success status and 4.08 times (95% CI 1.15–14.52) higher in those who had kept animals. In students’ responses to the attitude questionnaire items, the epidemic sub-dimension had the highest level as 86.1%, and the antibiotic resistance sub-dimension had the lowest level as 77.2%. Conclusions The current study revealed that the awareness on One Health concept among medical interns is limited, however, students’ attitudes are positive. Recent SARS-CoV 2 pandemic showed us the urgent need for proper implementation of’ One Health approach in the medical education curriculum. Meanwhile, One Health focused courses should be introduced into the curriculum of final year medicine and related programs.

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