scholarly journals Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus

Viruses ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 49 ◽  
Author(s):  
Mariana Batista ◽  
Ana Braga ◽  
Guilherme Campos ◽  
Marcos Souza ◽  
Renata Matos ◽  
...  
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Zika Virus ◽  
Hydrodynamic Radius ◽  
Health Conditions ◽  
Scattering Data ◽  
Pharmacological Properties ◽  
Zikv Infection ◽  
Virucidal Effect ◽  
Dynamic Light Scattering Data

Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus.

Universality of fractal aggregates as probed by light scattering

1989 ◽  
Vol 423 (1864) ◽  
pp. 71-87 ◽  
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Master Curve ◽  
Rotational Diffusion ◽  
Fractal Dimensions ◽  
Scattering Data ◽  
Diffusion Limited ◽  
Single Master Curve ◽  
Using Data ◽  
Dynamic Light Scattering Data

Fractal colloid aggregates are studied with both static and dynamic light scattering. The dynamic light scattering data are scaled onto a single master curve, whose shape is sensitive to the structure of the aggregates and their mass distribution. By using the structure factor determined from computer-simulated aggregates, and including the effects of rotational diffusion, we predict the shape of the master curve for different cluster distributions. Excellent agreement is found between our predictions and the data for the two limiting régimes, diffusion-limited and reaction-limited colloid aggregation. Furthermore, using data from several completely different colloids, we find that the shapes of the master curves are identical for each régime. In addition, the cluster fractal dimensions and the aggregation kinetics are identical in each régime. This provides convincing experimental evidence of the universality of these two régimes of colloid aggregation.

Distribution analyses of multi-modal dynamic light scattering data

Polymer ◽  
2006 ◽  
Vol 47 (18) ◽  
pp. 6446-6456 ◽  
Author(s):  
Mitsuhiro Shibayama ◽  
Takeshi Karino ◽  
Satoshi Okabe
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Scattering Data ◽  
Dynamic Light Scattering Data

Influence of Regularization Matrix on Inversion of Bimodal Dynamic Light Scattering Data

2015 ◽  
Vol 42 (9) ◽  
pp. 0908003
Author(s):  
刘伟 Liu Wei ◽  
王雅静 Wang Yajing ◽  
陈文钢 Chen Wengang ◽  
马立修 Ma Lixiu ◽  
申晋 Shen Jin
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Scattering Data ◽  
Regularization Matrix ◽  
Dynamic Light Scattering Data
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