scholarly journals Insight into Influenza: A Virus Cap-Snatching

Viruses ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 641 ◽  
Author(s):  
Corey De Vlugt ◽  
Dorota Sikora ◽  
Martin Pelchat
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Influenza A Virus ◽  
Influenza A ◽  
Current Knowledge ◽  
Viral Mrna ◽  
Mrna Transcription ◽  
Rna Dependent Rna Polymerase ◽  
Cellular Dna ◽  
Insight Into

The influenza A virus (IAV) genome consists of eight single-stranded RNA segments. Each segment is associated with a protein complex, with the 3′ and 5′ ends bound to the RNA-dependent RNA polymerase (RdRp) and the remainder associated with the viral nucleoprotein. During transcription of viral mRNA, this ribonucleoprotein complex steals short, 5′-capped transcripts produced by the cellular DNA dependent RNA polymerase II (RNAPII) and uses them to prime transcription of viral mRNA. Here, we review the current knowledge on the process of IAV cap-snatching and suggest a requirement for RNAPII promoter-proximal pausing for efficient IAV mRNA transcription.

scholarly journals Model Suggesting that Replication of Influenza Virus Is Regulated by Stabilization of Replicative Intermediates

2004 ◽  
Vol 78 (17) ◽  
pp. 9568-9572 ◽  
Author(s):  
Frank T. Vreede ◽  
Tanis E. Jung ◽  
George G. Brownlee
Keyword(s):  
Rna Polymerase ◽  
Influenza A Virus ◽  
Influenza A ◽  
Rna Synthesis ◽  
Viral Rna ◽  
Mrna Transcription ◽  
Rna Dependent Rna Polymerase ◽  
Replicative Intermediates ◽  
Negative Sense ◽  
Transcription And Replication

ABSTRACT The RNA-dependent RNA polymerase of influenza A virus is responsible for both transcription and replication of negative-sense viral RNA. It is thought that a “switching” mechanism regulates the transition between these activities. We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection. We suggest that there may be no switch regulating the initiation of RNA synthesis and present a model suggesting that nascent cRNA is degraded by host cell nucleases unless it is stabilized by newly synthesized viral RNA polymerase and NP.

scholarly journals Recruitment of RED-SMU1 Complex by Influenza A Virus RNA Polymerase to Control Viral mRNA Splicing

2014 ◽  
Vol 10 (6) ◽  
pp. e1004164 ◽  
Author(s):  
Guillaume Fournier ◽  
Chiayn Chiang ◽  
Sandie Munier ◽  
Andru Tomoiu ◽  
Caroline Demeret ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Influenza A Virus ◽  
Influenza A ◽  
Mrna Splicing ◽  
Viral Mrna ◽  
Virus Rna

scholarly journals Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein

2016 ◽  
Vol 12 (2) ◽  
pp. e1005427 ◽  
Author(s):  
Denys A. Khaperskyy ◽  
Summer Schmaling ◽  
Jonah Larkins-Ford ◽  
Craig McCormick ◽  
Marta M. Gaglia
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Influenza A Virus ◽  
Influenza A ◽  
Selective Degradation ◽  
Host Shutoff

scholarly journals Nuclear Export of Influenza A Virus mRNAs Requires Ongoing RNA Polymerase II Activity

Traffic ◽  
2006 ◽  
Vol 8 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Maria-Joao Amorim ◽  
Eliot K. Read ◽  
Rosa M. Dalton ◽  
Liz Medcalf ◽  
Paul Digard
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Influenza A Virus ◽  
Nuclear Export ◽  
Influenza A ◽  
Virus Mrnas
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