scholarly journals Molecular and Clinical Characterization of Chikungunya Virus Infections in Southeast Mexico

Viruses ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 248 ◽  
Author(s):  
Kame Galán-Huerta ◽  
Erik Martínez-Landeros ◽  
Juan Delgado-Gallegos ◽  
Sandra Caballero-Sosa ◽  
Iliana Malo-García ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Virus Infections ◽  
Southeast Mexico

scholarly journals Diagnosis and Molecular Characterization of Chikungunya Virus Infections

2019 ◽  
Author(s):  
Marta E. Álvarez-Argüelles ◽  
Susana Rojo Alba ◽  
Mercedes Rodríguez Pérez ◽  
Jose Antonio Boga Riveiro ◽  
Santiago Melón García
Keyword(s):  
Molecular Characterization ◽  
Chikungunya Virus ◽  
Virus Infections

scholarly journals Chikungunya Virus Infections Among Patients with Dengue-Like Illness at a Tertiary Care Hospital in the Philippines, 2012–2013

2015 ◽  
Vol 93 (6) ◽  
pp. 1318-1324 ◽  
Author(s):  
John Mark Velasco ◽  
Yongyuth Poolpanichupatam ◽  
Vito Roque ◽  
Kittinun Hussem ◽  
Rene Latog ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
The Philippines ◽  
Care Hospital ◽  
Virus Infections

scholarly journals Molecular Characterisation of Chikungunya Virus Infections in Trinidad and Comparison of Clinical and Laboratory Features with Dengue and Other Acute Febrile Cases

2015 ◽  
Vol 9 (11) ◽  
pp. e0004199 ◽  
Author(s):  
Nikita Sahadeo ◽  
Hamish Mohammed ◽  
Orchid M. Allicock ◽  
Albert J. Auguste ◽  
Steven G. Widen ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Molecular Characterisation ◽  
Virus Infections ◽  
Laboratory Features

scholarly journals Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues

2012 ◽  
Vol 445 (1) ◽  
pp. 113-123 ◽  
Author(s):  
Johan Vande Voorde ◽  
Federico Gago ◽  
Kristof Vrancken ◽  
Sandra Liekens ◽  
Jan Balzarini
Keyword(s):  
Nucleoside Analogues ◽  
Kinetic Properties ◽  
Virus Infections ◽  
Pyrimidine Nucleoside ◽  
Mycoplasma Hyorhinis ◽  
Nucleoside Phosphorylase ◽  
Secondary Infections ◽  
Pyrimidine Nucleoside Phosphorylase ◽  
In Silico Analyses

In the present paper we demonstrate that the cytostatic and antiviral activity of pyrimidine nucleoside analogues is markedly decreased by a Mycoplasma hyorhinis infection and show that the phosphorolytic activity of the mycoplasmas is responsible for this. Since mycoplasmas are (i) an important cause of secondary infections in immunocompromised (e.g. HIV infected) patients and (ii) known to preferentially colonize tumour tissue in cancer patients, catabolic mycoplasma enzymes may compromise efficient chemotherapy of virus infections and cancer. In the genome of M. hyorhinis, a TP (thymidine phosphorylase) gene has been annotated. This gene was cloned, expressed in Escherichia coli and kinetically characterized. Whereas the mycoplasma TP efficiently catalyses the phosphorolysis of thymidine (Km=473 μM) and deoxyuridine (Km=578 μM), it prefers uridine (Km=92 μM) as a substrate. Our kinetic data and sequence analysis revealed that the annotated M. hyorhinis TP belongs to the NP (nucleoside phosphorylase)-II class PyNPs (pyrimidine NPs), and is distinct from the NP-II class TP and NP-I class UPs (uridine phosphorylases). M. hyorhinis PyNP also markedly differs from TP and UP in its substrate specificity towards therapeutic nucleoside analogues and susceptibility to clinically relevant drugs. Several kinetic properties of mycoplasma PyNP were explained by in silico analyses.

Characterization of dengue virus infections in a sample of patients suggests unique clinical, immunological, and virological profiles that impact on the diagnosis of dengue and dengue hemorrhagic fever

2016 ◽  
Vol 88 (10) ◽  
pp. 1703-1710 ◽  
Author(s):  
Thamarasi Senaratne ◽  
Harith Wimalaratne ◽  
D. G. S. Alahakoon ◽  
Nirmali Gunawardane ◽  
Jillian Carr ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dengue Hemorrhagic Fever ◽  
Hemorrhagic Fever ◽  
Virus Infections
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