scholarly journals Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication

Viruses ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 191 ◽  
Author(s):  
Todd Bell ◽  
Virginia Espina ◽  
Lindsay Lundberg ◽  
Chelsea Pinkham ◽  
Ashwini Brahms ◽  
...  
Keyword(s):  
Virus Replication ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Kinase Inhibitor ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever ◽  
Inhibitor Treatment

scholarly journals Virion-associated spermidine transmits with Rift Valley fever virus particles to maintain infectivity

2020 ◽  
Author(s):  
Vincent Mastrodomenico ◽  
Jeremy J. Esin ◽  
Shefah Qazi ◽  
Oreoluwa S. Omoba ◽  
Brittany L. Fung ◽  
...  
Keyword(s):  
Virus Replication ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rna Virus ◽  
Rift Valley Fever Virus ◽  
Acid Synthesis ◽  
Fever Virus ◽  
Virus Infectivity ◽  
Cellular Functions ◽  
Valley Fever

AbstractViruses require host cell metabolites to productively infect, and the mechanisms by which viruses usurp these molecules is diverse. One group of cellular metabolites important in virus infection is the polyamines, small positively-charged molecules involved in cell cycle, translation, and nucleic acid synthesis, among other cellular functions. Polyamines also support replication of diverse viruses, and they are important for processes such as transcription, translation, and viral protein enzymatic activity. Rift Valley fever virus (RVFV) is a negative-sense RNA virus that requires polyamines to produce infectious particles. In polyamine depleted conditions, noninfectious particles are produced that interfere with virus replication and stimulate immune signaling. Here, we find that RVFV relies on virion-associated polyamines to maintain infectivity. We show that RVFV replication is facilitated by any of the three biogenic polyamines; however, we specifically find spermidine associated with purified virions. Using a panel of polyamine homologs, we observe that virions can also associate with (R)-3-methylspermidine and norspermidine, though not with other less homologous molecules. Using polyamine reporter cells, we demonstrate that virion-associated polyamines transmit from one infected cell to another. Finally, we find that virions devoid of polyamines are unstable and cannot be supplemented with exogenous polyamines to regain stability or infectivity. These data highlight a unique role for polyamines, and spermidine in particular, in maintaining virus infectivity, a function not previously appreciated. Further, these studies are the first to identify polyamines associated with RVFV virions. Targeting polyamines represents a promising antiviral strategy, and this work highlights a new mechanism by which we can inhibit virus replication through FDA-approved polyamine depleting pharmaceuticals.

scholarly journals Comparison of Rift Valley fever virus replication in North American livestock and wildlife cell lines

2015 ◽  
Vol 6 ◽  
Author(s):  
Natasha N. Gaudreault ◽  
Sabarish V. Indran ◽  
P. K. Bryant ◽  
Juergen A. Richt ◽  
William C. Wilson
Keyword(s):  
Cell Lines ◽  
Virus Replication ◽  
North American ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever

scholarly journals Curcumin Inhibits Rift Valley Fever Virus Replication in Human Cells

2012 ◽  
Vol 287 (40) ◽  
pp. 33198-33214 ◽  
Author(s):  
Aarthi Narayanan ◽  
Kylene Kehn-Hall ◽  
Svetlana Senina ◽  
Lindsay Lundberg ◽  
Rachel Van Duyne ◽  
...  
Keyword(s):  
Virus Replication ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Human Cells ◽  
Fever Virus ◽  
Valley Fever

scholarly journals Rift Valley Fever Virus NSs mRNA Is Transcribed from an Incoming Anti-Viral-Sense S RNA Segment

2005 ◽  
Vol 79 (18) ◽  
pp. 12106-12111 ◽  
Author(s):  
Tetsuro Ikegami ◽  
Sungyong Won ◽  
C. J. Peters ◽  
Shinji Makino
Keyword(s):  
Rift Valley ◽  
Mammalian Cells ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Viral Mrna ◽  
Mrna Synthesis ◽  
Valley Fever ◽  
Negative Sense ◽  
Inhibitor Treatment

ABSTRACT Analysis of purified Rift Valley fever virus (RVFV) particles demonstrated the presence of three negative-sense RNA genomes, plus three anti-viral-sense RNA segments. The virion-associated anti-viral-sense S segment served as a template for the synthesis of NSs mRNA immediately after infection. NSs protein synthesis also occurred early in infection, suggesting that NSs protein produced early in infection probably has biologically significant roles in virus replication and/or survival in the host. Translation inhibitor treatment of mammalian cells infected with viruses belonging to the Bunyaviridae family generally inhibits viral mRNA synthesis. However, RVFV NSs mRNA synthesis, but not N mRNA synthesis, was resistant to puromycin treatment during primary transcription, pointing to the uniqueness of RVFV NSs mRNA synthesis.

scholarly journals Protein Phosphatase-1 regulates Rift Valley fever virus replication

2016 ◽  
Vol 127 ◽  
pp. 79-89 ◽  
Author(s):  
Alan Baer ◽  
Nazly Shafagati ◽  
Ashwini Benedict ◽  
Tatiana Ammosova ◽  
Andrey Ivanov ◽  
...  
Keyword(s):  
Virus Replication ◽  
Protein Phosphatase ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Protein Phosphatase 1 ◽  
Valley Fever

scholarly journals Deletion of the NSm Virulence Gene of Rift Valley Fever Virus Inhibits Virus Replication in and Dissemination from the Midgut of Aedes aegypti Mosquitoes

2014 ◽  
Vol 8 (2) ◽  
pp. e2670 ◽  
Author(s):  
Rebekah C. Kading ◽  
Mary B. Crabtree ◽  
Brian H. Bird ◽  
Stuart T. Nichol ◽  
Bobbie Rae Erickson ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Virus Replication ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Virulence Gene ◽  
Fever Virus ◽  
Valley Fever

scholarly journals Curcumin inhibits Rift Valley fever virus replication in human cells.

2014 ◽  
Vol 289 (33) ◽  
pp. 22671-22671
Author(s):  
Aarthi Narayanan ◽  
Kylene Kehn-Hall ◽  
Svetlana Senina ◽  
Lindsay Lundberg ◽  
Rachel Van Duyne ◽  
...  
Keyword(s):  
Virus Replication ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Human Cells ◽  
Fever Virus ◽  
Valley Fever

Complement fixation reaction of Rift Valley fever virus

1950 ◽  
Vol 5 (5) ◽  
pp. 243-247
Author(s):  
Minoru MATSUMOTO ◽  
Saburo IWASA ◽  
Motosige ENDO
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Complement Fixation ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever ◽  
Fixation Reaction
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