scholarly journals Recent Advances in Handedness Genetics

Symmetry ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1792
Author(s):  
Silvia Paracchini
Keyword(s):  
Molecular Genetic ◽  
Genetic Associations ◽  
Genetic Studies ◽  
Genetic Analyses ◽  
Large Sample ◽  
Individual Level ◽  
Left Hand ◽  
Cerebral Asymmetries ◽  
The World ◽  
Fixed Proportion

Around the world, about 10% people prefer using their left-hand. What leads to this fixed proportion across populations and what determines left versus right preference at an individual level is far from being established. Genetic studies are a tool to answer these questions. Analysis in twins and family show that about 25% of handedness variance is due to genetics. In spite of very large cohorts, only a small fraction of this genetic component can be pinpoint to specific genes. Some of the genetic associations identified so far provide evidence for shared biology contributing to both handedness and cerebral asymmetries. In addition, they demonstrate that handedness is a highly polygenic trait. Typically, handedness is measured as the preferred hand for writing. This is a very convenient measure, especially to reach large sample sizes, but quantitative measures might capture different handedness dimensions and be better suited for genetic analyses. This paper reviews the latest findings from molecular genetic studies as well as the implications of using different ways of assessing handedness.

scholarly journals “Raptus Sabinae?” complemented: molecular genetic studies on a female calvarium of the Bandkeramik settlement of Rovantsi in Volhynia (UA)

2020 ◽  
Vol 72 (2) ◽  
Author(s):  
Janine Mazanec ◽  
Susanne Hummel ◽  
Thomas Saile
Keyword(s):  
Molecular Genetic ◽  
Skeletal Remains ◽  
Early Neolithic ◽  
Hair Colour ◽  
Genetic Studies ◽  
Genetic Analyses ◽  
Eye Colour

A fragmented human cranial calotte was discovered in a Bandkeramik (LBK) settlement context at Rovantsi in Volhynia (UA). The female calvarium of a mature woman with an age of about 45-50 years was uncovered in the deepest part of a settlement pit. It can be dated to round about 5,250 BC. PCR-based molecular genetic analyses were successfully performed on these extremely rare skeletal remains from the Early Neolithic of Ukraine. The female family line can be assigned to haplogroup T2, in which it represents the lineage T2c1d+152. The woman was lactose intolerant, like most LBK individuals. Her hair colour was brown, and her eye colour was found to be hazel.

scholarly journals Contribution of Russian zoologists to the collecting and first descriptions of the World avian fauna

2018 ◽  
Vol 322 (2) ◽  
pp. 144-159 ◽  
Author(s):  
V.A. Payevsky
Keyword(s):  
19Th Century ◽  
18Th Century ◽  
Molecular Genetic ◽  
Museum Collections ◽  
Genetic Studies ◽  
Geographical Society ◽  
The World ◽  
Academy Of Sciences ◽  
The 19Th Century ◽  
First Descriptions

A brief overview is given of the formation of museum collections of birds in Russia, collected as a result of academic expeditions around the world and across Russia. The imperishable value of zoological collections, concentrated in zoological museums and institutes, is underlined. The results of expeditions are described in chronology, beginning with 18th century (they were conducted under the auspices of the Russian Academy of Sciences and the Imperial Russian Geographical Society): the First Siberian expedition (D.G. Messershmidt), the First Kamchatka and the Great Northern expeditions (V.I. Bering, А.I. Chirikov, G.F. Müller, G.V. Stöller, I.G. Gmelin, S.P. Krasheninnikov), Great academic expeditions across Russia (P.S. Pallas, S.G. Gmelin, I.A. Güldenstädt, I.I. Lepyokhin, I.P. Falk, I.G. Georgi), round-the-world sea expeditions (I.F. Kruzenshtern and Yu.F. Lisyansky, F.F. Bellingshausen and M.P. Lazarev, F.G. Kittlitz and A.K. Mertens), as well as expeditions to Brazil (G. I. Langsdorf and E.P. Menetries) and expedition of I.G. Voznesensky in Russian America, the Commanders and Kamchatka. Reference is made to the importance of zoological expeditions of K.F. von Baer, A.F. Middendorf, G.I. Radde, N.A. Severtsov, M.N. Bogdanov, G.E. and M.E. Grumm-Grzhimailo. Particular attention is paid to the great Asian campaigns to Central Asia in the late XIX – early XX century of NM. Przevalsky, V.I. Roborovsky, P.K. Kozlov, G.N. Potanin, M.V. Pevtsov, B.L. Grombchevsky, M.A. Pyltsov and N.A. Zarudny. The contribution of the ornithologists of Russia M.N.Bogdanov, M.M. Berezovsky, M.A. Menzbir, V.L. Bianchi, F.D. Pleske, V.I. Dybowski, V.A. Godlewski, M.I. Jankowski, V.K. Taczanowski, P.P. Sushkin and S.A. Buturlin to the bird systematics at the end of the 19th century and the beginning of XX century is described. In conclusion, it is said about the unique value of zoological collections for the study of taxonomy and phylogeny, including on the basis of molecular genetic studies.

scholarly journals Phenotypic and genetic complexity of psychosis

2007 ◽  
Vol 190 (3) ◽  
pp. 200-203 ◽  
Author(s):  
Nick Craddock ◽  
Michael C. O'Donovan ◽  
Michael J. Owen
Keyword(s):  
Molecular Genetic ◽  
Clinical Heterogeneity ◽  
Genetic Studies ◽  
Dna Variation ◽  
Individual Level ◽  
Complex Disorders ◽  
Risk Variants ◽  
Genetic Complexity ◽  
The Common ◽  
The Individual

SummaryPsychosis, like other major psychiatric disorders, is both genetically and clinically complex. Increasingly powerful molecular genetic studies have the potential to identify DNA variation that influences susceptibility to genetically complex disorders. There is a need to use a range of genetic approaches appropriate to identifying a spectrum of risk variants from the common through to the rare. Some variants might have large effects at the level of the individual but most are likely to have modest or small effects at both population and individual level. Extensive clinical heterogeneity is likely to have a significant impact on the power of even the largest studies and, more importantly, will lead to extensive variability between studies and hamper attempts at replication. If we are to realise the potential of molecular genetics, we need to overcome the major limitations imposed by current psychiatric diagnostic classifications and identify clinical phenotypes that reflect the presence of underlying entities with biological validity.

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