scholarly journals Isolation and Structure Elucidation of a Novel Symmetrical Macrocyclic Phthalate Hexaester

Symmetry ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 361
Author(s):  
Michiya Kamio ◽  
Weina Jiang ◽  
Hiroki Osada ◽  
Masayuki Fukuoka ◽  
Hajime Uchida ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Antibacterial Activity ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Natural Product ◽  
Spectroscopic Data ◽  
Structure Elucidation ◽  
Mass Spectra ◽  
Activity Test ◽  
Resolution Mass

A novel symmetrical macrocyclic phthalate hexaester (1) and a known macrocyclic phthalate tetraester (2) were isolated during a natural product-exploring program on the cyanobacterium Moorea producens. Their structures were elucidated based on spectroscopic data, including nuclear magnetic resonance and high-resolution mass spectra. In the antibacterial activity test, compounds 1 and 2 showed no bioactivity at the concentrations tested.

scholarly journals Neo-Aplysiatoxin A Isolated from Okinawan Cyanobacterium Moorea Producens

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 457 ◽  
Author(s):  
Mioko Kawaguchi ◽  
Masayuki Satake ◽  
Bo-Tao Zhang ◽  
Yue-Yun Xiao ◽  
Masayuki Fukuoka ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Growth Inhibition ◽  
Spectroscopic Data ◽  
High Resolution Mass Spectrometry ◽  
High Resolution Mass ◽  
Resolution Mass ◽  
Nuclear Magnetic

A new aplysiatoxin derivative, neo-aplysiatoxin A (1), along with seven known compounds, neo-debromoaplysiatoxin A (2), dolastatin 3 (3), lyngbic acid (4), malyngamide M (5), hermitamide A (6), (−)-loliolide (7), and (+)-epiloliolide (8), was isolated from the Okinawan cyanobacterium Moorea producens. Their structures were elucidated on the basis of spectroscopic data, including high-resolution mass spectrometry and nuclear magnetic resonance. The compounds were evaluated for cytotoxic and diatom growth inhibition activities.

scholarly journals Synthesis of spiro[benzo[4,5]imidazo[2,1-b][1,3]thiazole-2,3-thiolane]s via sulfa-Michael/aldol cascade reactions

2019 ◽  
Vol 43 (1-2) ◽  
pp. 63-66 ◽  
Author(s):  
Jiaying Lei ◽  
Xinliang Fu ◽  
Yulin Huang ◽  
Xiaofang Li
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Cascade Reactions ◽  
Cascade Reaction ◽  
Crystallographic Analysis ◽  
X Ray ◽  
Resolution Mass

The sulfa-Michael/aldol cascade reaction of ( Z)-2-arylmethylidene-benzo[4,5]imidazo[2,1- b]thiazol-3(2H)-ones and 1,4-dithiane-2,5-diol afforded novel 2-aryl-4-hydroxy-spiro[benzo[4,5]imidazo[2,1- b][1,3]thiazole-2,3-thiolan]-3-ones in moderate yields. The structures of all the products were characterized thoroughly by nuclear magnetic resonance, infrared and high-resolution mass spectrometry together with X-ray crystallographic analysis.

scholarly journals Two New AChE Inhibitors Isolated from Li Folk Herb Heilaohu “Kadsura coccinea” Stems

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3628
Author(s):  
Sheng Zhuo Huang ◽  
Lin Ping Duan ◽  
Hao Wang ◽  
Wen Li Mei ◽  
Hao Fu Dai
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Spectroscopic Data ◽  
Positive Control ◽  
Ache Inhibitors ◽  
Activity Test ◽  
Ache Inhibitory Activity ◽  
Kadsura Coccinea ◽  
Ellman’S Method

Two new triterpenoids, named kadsuricoccins A and B, together with three known ones, were isolated from the Li folk herb Heilaohu, the stems of Kadsura coccinea (Lem.) A. C. Smith, which was used for food and as a healthy supplement. Their structures were elucidated by comprehensive analyses of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data. To search healthy components, an acetylcholinesterase (AChE) inhibitory activity test by Ellman’s Method was conducted, kadsuricoccins A and B showed activity with the AChE inhibit index (AII) up to 68.96% ± 0.19% and 57.8% ± 0.11% at 94 nM (compared with positive control tacrine AII 79.80% ± 0.20%, 9.4 nM), respectively.

scholarly journals Limonoids From Choerospondias axillaris

2020 ◽  
Vol 15 (8) ◽  
pp. 1934578X2094836
Author(s):  
Nguyen Huu Toan Phan ◽  
Nguyen Thi Dieu Thuan ◽  
Nguyen Thi Thu Hien ◽  
Pham Van Huyen ◽  
Tran Thi Hong Hanh ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Electrospray Ionization ◽  
Mass Spectra ◽  
Inhibitory Concentration ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Human Cancer Cell ◽  
Chromatographic Separations

Eight limonoids (1-8), including 1 new compound named as axillariol A (1), were isolated from the dichloromethane extract of Choerospondias axillaris branches and leaves using various chromatographic separations. Their structures were confirmed by detailed analysis of the 1-dimensional (1D), 2D nuclear magnetic resonance, and high-resolution electrospray ionization quadrupole time-of-flight mass spectra. In addition, toonaciliatins N (6) and toonaciliatins O (7) showed selective and significant cytotoxicity on the rhabdomyosarcoma human cancer cell line with half-maximal inhibitory concentration values of 9.12 and 7.79 µM, respectively.

Synthesis of 1,2,3-triazole-substituted 6,7-dihydroindolizin-8(5H)-one derivatives mediated by Selectfluor

2019 ◽  
Vol 43 (5-6) ◽  
pp. 179-183
Author(s):  
Yulin Huang ◽  
Jiaying Lei ◽  
Xinliang Fu ◽  
Wenlin Xie ◽  
Xiaofang Li
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Crystallographic Analysis ◽  
X Ray ◽  
High Resolution Mass ◽  
Moderate Yield ◽  
Resolution Mass

The 1,2,3-triazole and 1 H-1,2,3-benzotriazole-substituted 6,7-dihydroindolizin-8(5 H)-one derivatives were synthesized by the reaction of ( E)-7-(arylmethylidene)-6,7-dihydroindolizin-8(5 H)-ones with 1,2,3-triazole and 1 H-1,2,3-benzotriazole in the presence of Selectfluor in moderate yield. The structures of all the products were characterized thoroughly by nuclear magnetic resonance, infrared, and high-resolution mass spectrometry together with X-ray crystallographic analysis.

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