scholarly journals Blood Pressure Correlates Asymmetrically with Neuropeptidase Activities of the Left and Right Frontal Cortices

Symmetry ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 105
Author(s):  
Ana Belén Segarra ◽  
Isabel Prieto ◽  
Inmaculada Banegas ◽  
Magdalena Martínez-Cañamero ◽  
Marc de Gasparo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Frontal Cortex ◽  
Control Group ◽  
Physiological Processes ◽  
Propranolol Group ◽  
Membrane Bound ◽  
Left And Right ◽  
Positive Correlations ◽  
Cardio Vascular ◽  
The Right

It was suggested that the brain-heart connection is asymmetrically organized. However, evidence connecting neurochemical factors from each brain hemisphere with changes in cardio-vascular functions have not yet been reported. In order to analyze potential asymmetrical connections between brain neurochemical factors with cardio-vascular functions, we studied the level of correlations between the left and right frontal cortex (FC) soluble (Sol) and membrane-bound (MB) neuropeptide-degrading enzymes alanyl (AlaAP), cystinyl (CysAP), and glutamyl (GluAP) aminopeptidase activities, involved among others in the metabolism of angiotensins, with heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressure, in rats treated or not with hypotensive or hypertensive drugs such as captopril, propranolol or L-NAME. The present study suggests the existence of a bidirectional asymmetrical connection between these brain neuropeptidases and cardio-vascular functions. Specifically, depending on treatment, in control group, Sol AlaAP from the left FC correlates negatively with SBP and DBP. In captopril-treated animals, MB CysAP and MB GluAP from the right FC correlate negatively with HR. In L-NAME treated rats, Sol CysAP from the right FC correlates negatively with DBP. No significant correlations were observed in the propranolol group. Considering together all the values obtained from the left or the right cortex of the four groups regardless of drug treatment, the results demonstrated significant negative correlations between these neuropeptidase activities, mainly from the left frontal cortex, with the levels of systolic and diastolic blood pressure. Remarkably, these findings contrast drastically with previously reported results indicating significant positive correlations between the left frontal cortex with other peripheral functions such as water intake and diuresis. Both results represent noteworthy information that strongly supports the concept of a bidirectional asymmetric organization of neurovisceral integration involving left and right brain neurochemical processes with peripheral physiological functions, most probably mediated by the autonomic nervous system. Overall, the present results suggest that cognitive functions involving the frontal cortex may be asymmetrically connected with peripheral physiological processes, and vice versa.

scholarly journals The Brain-Heart Connection: Frontal Cortex and Left Ventricle Angiotensinase Activities in Control and Captopril-Treated Hypertensive Rats—A Bilateral Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ana B. Segarra ◽  
Isabel Prieto ◽  
Inmaculada Banegas ◽  
Ana B. Villarejo ◽  
Rosemary Wangensteen ◽  
...  
Keyword(s):  
Drinking Water ◽  
Left Ventricle ◽  
Frontal Cortex ◽  
Treated Group ◽  
The Other ◽  
Hypertensive Rats ◽  
Membrane Bound ◽  
Left And Right ◽  
The Right ◽  
The Brain

The model ofneurovisceral integrationsuggests that the frontal cortex (FC) and the cardiovascular function are reciprocally and asymmetrically connected. We analyzed several angiotensinase activities in the heart left ventricle (VT) of control and captopril-treated SHR, and we search for a relationship between these activities and those determined in the left and right FC. Captopril was administered in drinking water for 4 weeks. Samples from the left VT and from the left and right FC were obtained. Soluble and membrane-bound enzymatic activities were measured fluorometrically using arylamides as substrates. The weight of heart significantly decreased after treatment with captopril, mainly, due to the reduction of the left VT weight. In the VT, no differences for soluble activities were observed between control and treated SHR. In contrast, a generalized significant reduction was observed for membrane-bound activities. The most significant correlations between FC and VT were observed in the right FC of the captopril-treated group. The other correlations, right FC versus VT and left FC versus VT in controls and left FC versus VT in the captopril group, were few and low. These results confirm that the connection between FC and cardiovascular system is asymmetrically organized.

scholarly journals Effect of dental wear, stabilization appliance and anterior tooth reconstruction on mandibular movements during speech

2008 ◽  
Vol 19 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Priscila de Oliveira Serrano ◽  
Fernanda Faot ◽  
Altair Antoninha Del Bel Cury ◽  
Renata Cunha Matheus Rodrigues Garcia
Keyword(s):  
Tooth Wear ◽  
Anterior Tooth ◽  
Control Group ◽  
Dental Wear ◽  
Jaw Opening ◽  
Before And After ◽  
Left And Right ◽  
The Right ◽  
Tracking Device ◽  
Mandibular Movements

This study described changes in mandibular movements during pronunciation of /m/ and /s/ sounds in Portuguese, in patients presenting dental wear before and after appliance insertion and tooth reconstruction. Subjects were divided into a control group of dentate patients and an experimental group of patients with incisal tooth wear due to bruxism. A magnetic jaw tracking device measured the jaw opening, and translations to left and right sides of the mandible during pronunciation of phonemes. Evaluations were carried out 1 week and immediately before appliance insertion; 24 h, 7, 30 and 60 days after appliance insertion; and 1 week and 1 month after tooth reconstruction. Data were submitted to two-way ANOVA, Mann-Whitney and Friedman tests (p<0.05). Jaw opening was different (p<0.05) for both sounds in all periods. The anteroposterior amplitude for /s/ showed differences immediately before and 1 month after appliance insertion (p<0.05). Lateral amplitude for the right side showed differences between groups after appliance insertion for /s/, and 1 and 2 months after appliance insertion for the /m/ (p<0.05). Volunteers with anterior tooth wear had a wider opening movement, and the movements during speech of /m/ and /s/ sounds were not changed after appliance insertion and reconstruction of teeth.

scholarly journals Total Endoscopic Thyroidectomy with Intraoperative Laryngeal Nerve Monitoring

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Bin Lv ◽  
Bin Zhang ◽  
Qing-Dong Zeng
Keyword(s):  
Endoscopic Thyroidectomy ◽  
Risk Difference ◽  
Laryngeal Nerve ◽  
Control Group ◽  
Injury Rates ◽  
Nerve Monitoring ◽  
Hand Surgeon ◽  
Joint Application ◽  
Left And Right ◽  
The Right

Objective. To evaluate the clinical efficacy of laryngeal nerve (LN) monitoring (LNM) during total endoscopic thyroidectomy via breast approach, with emphasis on the identification rates for RLN and EBSLN and the incidence of RLN paralysis. Materials and Methods. This retrospective study included 280 patients who underwent endoscopic thyroidectomy with or without LNM. RLN and EBSLN were identified using endoscopic magnification in the control group, while they were localized additionally by LNM in the LNM group. Demographic parameters and surgical outcomes were analyzed by statistical methods. Patients in the control group were also stratified by the side of thyroidectomy to determine difference in left and right RLN injury rates. Results. All procedures were successfully conducted without permanent LN damage. The identification rates for RLN and EBSLN were high in the LNM group compared to those of the control group, and the risk difference (RD) of temporary RLN injury between two groups was 6.3%. The risk of damage was slightly higher for the left RLN than for the right RLN in the control group, which was performed by a right-hand surgeon. Conclusion. The joint application of LNM and endoscopic magnified view endows total endoscopic thyroidectomy with ease, safety, and efficiency.

Baroreflex modulation of heart rate and initiation of atrial activation in dogs

1988 ◽  
Vol 255 (3) ◽  
pp. H503-H513 ◽  
Author(s):  
R. B. Schuessler ◽  
T. E. Canavan ◽  
J. P. Boineau ◽  
J. L. Cox
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Right Atrial ◽  
Autonomic Blockade ◽  
Left And Right ◽  
Atrial Activation ◽  
The Right ◽  
A Site ◽  
Induced Changes ◽  
Cardiac Nerves

In open-chest dogs, blood pressure was regulated by titrating doses of phenylephrine and nitroprusside to determine its effect on heart rate and pacemaker location. Changes in blood pressure correlated with changes in heart rate (r = 0.86). Activation time mapping demonstrated multicentric atrial activation, with a site of origin-rate relationship. The fastest pacemakers were located in the most cranial regions and slowest in the most caudal areas. In this chloralose-morphine anesthetized model, autonomic blockade with atropine and propranolol suggests that acute baroreflex-induced changes in heart rate were mediated exclusively by either increased sympathetic or parasympathetic tone and were not associated with inhibition of the opposite system. Division of right and left thoracic cardiac nerves indicated the left sympathetics participated in the baroreflex in 50% of the animals and the left parasympathetics in 90% of the animals. Both the right sympathetics and parasympathetics were active in the baroreflex in all animals. The data demonstrate that physiological heart rate response is regulated through an extensive system of right atrial pacemakers modulated by both left and right efferent cardiac nerves.

ENDOTHELIAL DYSFUNCTION AND NEUROHUMORAL REGULATION OF BLOOD PRESSURE IN PATIENTS WITH SYSTEMIC SCLEROSIS

2019 ◽  
Vol 57 (4) ◽  
pp. 445-451
Author(s):  
N. P. Shilkina ◽  
I. E. Yunonin ◽  
S. A. Stolyarova ◽  
A. A. Vinogradov
Keyword(s):  
Blood Pressure ◽  
Systemic Sclerosis ◽  
Endothelial Dysfunction ◽  
Clinical Symptoms ◽  
Negative Impact ◽  
Endothelial Activation ◽  
Control Group ◽  
Neurohumoral Regulation ◽  
Positive Correlations

Objective: to investigate the effect of endothelial dysfunction, catecholamines, and renin on the diurnal blood pressure (BP) profile in patients with systemic sclerosis (SS).Subjects and methods. Twenty-five patients with SS underwent determination of the blood count of desquamated endotheliocytes by the method described by J. Hladovec (1978), the plasma levels of endothelin-1 (ET-1), adrenaline, norepinephrine, and renin by enzyme immunoassay. All the patients underwent 24-hour BP monitoring with calculating the time index, daily index, the magnitude and rate of a morning rise in BP, as well as its daily variability.Results and discussion. Hypertension was detected in 8 (32%) patients with SS. All the patients with SS showed signs of endothelial dysfunction, as evidenced by considerable differences in endothelial activation measures compared with the control group: the mean level of ET-1 was 5.8±2.3 and 0.48±0.21 fmol/ml (p<0.05); the number of desquamated endotheliocytes was 4.50 [3.00; 7.00] and 2.10 [1.00; 3.20] • 104/l, respectively (p<0.05). The levels of adrenaline and norepinephrine in SS were significantly higher than those in the control. There were positive correlations between endothelial dysfunction and the degree of an increase in BP. Endothelial dysfunction was found to have a negative impact on the diurnal BP profile in the presence of pathological types of night-peaker and non-dipper. Conclusion. Two mechanisms, such as endothelial dysfunction and sympathoadrenal activation, are responsible for the pathogenesis of clinical symptoms of SS, including hypertension.

Spectral Analysis of Heart Rate Variability during Trigger Point Acupuncture

2014 ◽  
Vol 32 (3) ◽  
pp. 273-278 ◽  
Author(s):  
Yoji Kitagawa ◽  
Kenichi Kimura ◽  
Sohei Yoshida
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Spectral Analysis ◽  
Tibialis Anterior ◽  
Trigger Point ◽  
Tibialis Anterior Muscle ◽  
Trigger Points ◽  
Control Group ◽  
The Right

Objectives To clarify changes in the cardiovascular autonomic nervous system function due to trigger point acupuncture, we evaluated differences in responses between acupuncture at trigger points and those at other sites using spectral analysis of heart rate variability. Methods Subjects were 35 healthy men. Before measurements began the subjects were assigned to a trigger point acupuncture or control group based on the presence/absence of referred pain on applying pressure to a taut band within the right tibialis anterior muscle. The measurements were conducted in a room with a temperature of 25°C, with subjects in a long sitting position after 10 min rest. Acupuncture needles were retained for 10 min at two sites on the right tibialis anterior muscle. ECG was performed simultaneously with measurements of blood pressure and the respiratory cycle. Based on the R–R interval on the ECG, frequency analysis was performed, low-frequency (LF) and high-frequency (HF) components were extracted and the ratio of LF to HF components (LF/HF) was evaluated. Results The trigger point acupuncture group showed a transient decrease in heart rate and an increase in the HF component but no significant changes in LF/HF. In the control group, no significant changes were observed in heart rate, the HF component or LF/HF. There were no consistent changes in systolic or diastolic blood pressure in either group. Conclusions These data suggest that acupuncture stimulation of trigger points of the tibialis anterior muscle transiently increases parasympathetic nerve activity.

scholarly journals Handedness and gender influence blood pressure in young healthy men and women: A pilot study

2016 ◽  
Vol 50 (1) ◽  
pp. 10-15 ◽  
Author(s):  
I Rueda ◽  
I Banegas ◽  
I Prieto ◽  
R Wangensteen ◽  
AB Segarra ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sex Hormones ◽  
Sex Steroids ◽  
Menstrual Phase ◽  
Men And Women ◽  
Left Handed ◽  
Gender Influence ◽  
Left And Right ◽  
And Gender ◽  
The Right

AbstractObjective. The type and level of sex steroids influence blood pressure (BP). It has been suggested that functional brain asymmetries may be influenced by sex hormones. In addition, there are inter-arm differences in BP not yet related with handedness. In this study, we hypothesize a possible association between sex hormones, handedness, and inter-arm differences in blood pressure.Methods. To analyze this hypothesis, we measured BP in the left and right arm of the left and right handed adult young men and women in menstrual and ovulatory phase and calculated their mean arterial pressure (MAP).Results. Significant differences depending on sex, arm, handedness or phase of the cycle were observed. MAP was mostly higher in men than in women. Remarkably, in women, the highest levels were observed in the left handed in menstrual phase. Interestingly, the level of handedness correlated negatively with MAP measured in the left arm of right-handed women in the ovulatory phase but positively with the MAP measured in the right arm of right-handed women in the menstrual phase.Conclusions. These results may reflect an asymmetrical modulatory influence of sex hormones in BP control.

scholarly journals Intima-Media Thickness Measurements of the Common Carotid Artery in Patients with Central Serous Chorioretinopathy: A Case-Control Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Kobra Nasrollahi ◽  
Amirhossein Farahi ◽  
Fatemeh Paknazar ◽  
Mohamadreza Akhlaghi ◽  
Farhad Fazel ◽  
...  
Keyword(s):  
Central Serous Chorioretinopathy ◽  
Case Control Study ◽  
Intima Media Thickness ◽  
Case Control ◽  
Control Group ◽  
Media Thickness ◽  
Left And Right ◽  
The Difference ◽  
The Right ◽  
Control Study

Purpose. To evaluate the intima-media thickness (IMT) of the left and right common carotid arteries (CCA) as an indicator of subclinical atherosclerosis in patients with central serous chorioretinopathy (CSCR). Methods. This was a case-control study involving patients with CSCR and a matched healthy control group. The mean and difference of the left and right CCA IMT were determined and compared between the two groups using carotid duplex high-resolution B-mode ultrasound equipment. Results. The study enrolled 32 CSCR patients (68.8% female, mean age 38.22 ± 5.42 years) and 32 controls (65.6% female, mean age 39.56 ± 5.33 years). The difference in common carotid IMT between the right and left sides was significantly greater in the CSCR group than in the control group ( p < 0.001 ). Additionally, according to logistic regression analysis, patients with CSCR had a greater chance of having differences in IMT between the two sides when compared to the control group (OR: 1.29, 95% CI: 1.09–1.52). Conclusion. Our findings indicated that in the CSCR group, the difference between the right and left sides of CCA IMT was significantly greater than in the control group.

scholarly journals Comparison of Intraocular Pressure among Individuals with Systemic Hypertension and those with Normal Blood Pressure

2021 ◽  
Vol 13 (2) ◽  
pp. 137-144
Author(s):  
Sanket Parajuli ◽  
Pooja Shrestha ◽  
Jeevan K Shrestha ◽  
Sadhana Sharma
Keyword(s):  
Blood Pressure ◽  
Intraocular Pressure ◽  
Normal Blood ◽  
Systemic Hypertension ◽  
Control Group ◽  
Case Group ◽  
Normal Blood Pressure ◽  
Hypertensive Group ◽  
Significant Difference ◽  
The Right

Introduction: Systemic blood pressure, by far, is one of the most important factors that can have an effect on intraocular pressure. We have compared the intraocular pressure (IOP) among patients with systemic hypertension and those with normal blood pressure. Materials and methods: A hospital based case control study was conducted from March 2017 to March 2018 in the Ophthalmology outpatient department at Dhulikhel Hospital. A total of 100 patients with hypertension were included in the case group (hypertensive group) and 100 cases with no systemic or ocular disease were included in the control group (normotensive group). Mean intraocular pressures were calculated and compared between the two groups. Results: Mean age of patients was 49.03 years in hypertensive group and 47.53 years in normotensive group. Mean IOP of the right eye in those with hypertension was 16.10 mmHg and in the left eye was 15.8 mmHg. Similarly mean IOP of the right eye in the normotensive group was 15.8 mmHg and the left eye was 16.2 mmHg. The difference between mean IOP of hypertensive and normotensive individuals was not statistically significant (p > 0.05). The prevalence of ocular hypertension was found to be 7.5%. Conclusion: There was no statistically significant difference in IOP between hypertensive and normotensive individuals. However, a statistically significant difference in IOP was noted between ‘hypertensive with controlled blood pressure’ and ‘hypertensive with uncontrolled BP’ indicating that high blood pressure may be associated with high IOP.

scholarly journals EFFECTS OF AEROBIC TRAINING ON THE CARDIOMYOCYTES OF THE RIGHT ATRIUM OF MICE

2016 ◽  
Vol 22 (5) ◽  
pp. 345-349
Author(s):  
Vanessa Gonçalves Coutinho de Oliveira ◽  
Laura Beatriz Mesiano Maifrino ◽  
Tania Cristina Pithon-Curi ◽  
Elias de França ◽  
Romeu Rodrigues de Souza
Keyword(s):  
Blood Pressure ◽  
Endoplasmic Reticulum ◽  
Golgi Complex ◽  
Natriuretic Peptides ◽  
Right Atrium ◽  
Aerobic Training ◽  
Relative Volume ◽  
Control Group ◽  
The Right ◽  
Secretory Apparatus

ABSTRACT Introduction: Polypeptide hormones (natriuretic peptides, NPs) are secreted by the cardiac atria and play an important role in the regulation of blood pressure. Objective: To evaluate the effects of aerobic training on the secretory apparatus of NPs in cardiomyocytes of the right atrium. Methods: Nine-month-old mice were divided in two groups (n=10): control group (CG) and trained group (TG). The training protocol was performed on a motor treadmill for 8 weeks. Systolic blood pressure was measured at the beginning of the experiment (9 months of age) and at moment of the sacrifice (11 months of age). Electron micrographs were used to quantify the following variables: the quantitative density and area of NP granules, the relative volumes of the mitochondria, endoplasmic reticulum, and Golgi complex and the relative volume of euchromatin in the nucleus and the number of pores per 10 µm of the nuclear membrane. The results were compared by Student's t test (p< 0.05). Results: The cardiomyocytes obtained from TG mice showed increased density and sectional area of secretory granules of NP, higher relative volume of endoplasmic reticulum, mitochondria, and Golgi complex compared with the CG mice. Furthermore, the quantitative density of nuclear pores and the relative volume of euchromatin in the nucleus were significantly higher compared with the CG mice. Conclusion: Aerobic training caused hypertrophy of the secretory apparatus in the cardiomyocytes of right atrium, which could explain the intense synthesis of natriuretic peptides in trained mice with respect to the untrained mice.

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