scholarly journals Easy Computation of the Various Topologies and Modes of Liquid–Liquid Partition Chromatography by the Theory of Random Walks

Separations ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 41
Author(s):  
Frédéric R. Dijoux ◽  
Tsvetelina Mandova
Keyword(s):  
Random Walks ◽  
Recurrence Relations ◽  
Concentration Profiles ◽  
Partition Chromatography ◽  
Centrifugal Partition Chromatography ◽  
Dual Mode ◽  
Stochastic Master Equation ◽  
Recurrence Method ◽  
Counter Current ◽  
Continuous Injection

The article revisits the discrete recurrence method to model the instruments of liquid–liquid partition chromatography as counter-current chromatography (CCC) and centrifugal partition chromatography (CPC). The purpose is to simplify the computation of the concentration profiles without supplementary approximations, rather by going back to the seminal model of binomial random walks, associated with the stochastic master equation that generates simple discrete recurrence relations. It fits the model of the prototype of liquid–liquid chromatography: the Craig’s apparatus. Three emblematic separation technique group cases are computed in batch injection, batch multiple dual mode (MDM), and continuous injection by the “True Moving Bed” (TMB) in CPC.

Effluent concentration profiles in centrifugal partition chromatography

AIChE Journal ◽  
1997 ◽  
Vol 43 (3) ◽  
pp. 693-702 ◽  
Author(s):  
M. J. van Buel ◽  
L. A. M. van der Wielen ◽  
K. Ch. A. M. Luyben
Keyword(s):  
Concentration Profiles ◽  
Partition Chromatography ◽  
Centrifugal Partition Chromatography ◽  
Effluent Concentration

Fast Counter Current Chromatography of n-Butanolic Fraction from Senecio giganteus (Asteraceae)

2009 ◽  
Vol 4 (10) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Nadjet Mezache ◽  
Séverine Derbré ◽  
Salah Akkal ◽  
Hocine Laouer ◽  
Denis Séraphin ◽  
...  
Keyword(s):  
Methyl Ester ◽  
2D Nmr ◽  
Spectrometric Analysis ◽  
Partition Chromatography ◽  
Centrifugal Partition Chromatography ◽  
Phytochemical Composition ◽  
Phenolic Derivatives ◽  
Counter Current ◽  
First Time ◽  
Fast Centrifugal Partition Chromatography

Phenolic derivatives such as quinones, acid-phenols and flavonoids were successfully isolated from a n-butanolic fraction of Senecio giganteus Desf. (Asteraceae) flowers, namely jacaranone (1), 3a-hydroxy-3,3a,7,7a-tetrahydrobenzofuran-2,6-dione (2), chlorogenic acid (3), hyperoside (4), quercetin 3-O-β-D-robinobioside (5), isorhamnetin-3-O-β-D-glucuronide (6), quercetin-3-O-β-D-glucuronide (7), and isorhamnetin-3-O-β-D-glucuronide-6″-methyl ester (8). These compounds were purified through either classical polyamide filtration followed by fractionation on Si gel, or through fast centrifugal partition chromatography (FCPC). Using FCPC, the major compounds could be readily isolated from the crude n-butanolic fraction. Compounds 1-8 were identified by means of spectroscopic and spectrometric analysis (UV, 1H, 13C and 2D NMR, and MS). This work described for the first time the phytochemical composition of this endemic Algerian plant.

Multiple dual-mode centrifugal partition chromatography, a semi-continuous development mode for routine laboratory-scale purifications

2006 ◽  
Vol 1127 (1-2) ◽  
pp. 45-51 ◽  
Author(s):  
Eldra Delannay ◽  
Alix Toribio ◽  
Leslie Boudesocque ◽  
Jean-Marc Nuzillard ◽  
Monique Zèches-Hanrot ◽  
...  
Keyword(s):  
Laboratory Scale ◽  
Routine Laboratory ◽  
Partition Chromatography ◽  
Centrifugal Partition Chromatography ◽  
Development Mode ◽  
Continuous Development ◽  
Dual Mode
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