scholarly journals Potential Role of Microfibrillar-Associated Protein 4, Fibrotic Indices and Oxidative Stress in Hepatocellular Carcinoma

2018 ◽  
Vol 86 (4) ◽  
pp. 44 ◽  
Author(s):  
Mohamed Salama ◽  
Manal Nomir ◽  
Maryan Fahmi ◽  
Amal El-Gayar ◽  
Mamdouh El-Shishtawy
Keyword(s):  
Oxidative Stress ◽  
Hepatocellular Carcinoma ◽  
Potential Role ◽  
Control Group ◽  
Significant Elevation ◽  
Cirrhotic Patients ◽  
Mechanisms Of Persistence ◽  
And Oxidative Stress ◽  
Related Mortality

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. In an attempt to understand some potential mechanisms of persistence and oncogenicity of Hepatitis C virus (HCV)-related HCC, microfibrillar-associated protein 4 (MFAP4), fibrotic indices and oxidative status biomarkers were assessed in the sera of 50 patients with HCV-associated HCC, 25 patients with HCV-related liver cirrhosis and 15 healthy individuals. Serum oxidized Coenzyme Q10 (CoQ10) and malondialdehyde showed significant elevation in HCC patients compared to the control group (p < 0.001), as well as cirrhotic patients (p < 0.05 and p < 0.001, respectively), while serum glutathione content and superoxide dismutase activity were significantly decreased in HCC patients compared to the control group (p < 0.001). Serum MFAP4, aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factors (FIB-4) and Forns index showed significant increase in HCC patients compared to the control group (p < 0.001), while only APRI and FIB-4 were significantly different between HCC and cirrhotic patients (p < 0.05), with a sensitivity of 86% and 92%, respectively, at cut off ≥0.7 for APRI and ≥1.57 for FIB-4. Therefore, increasing oxidative stress and fibrosis might mediate HCV induced cirrhosis and HCC. APRI and FIB-4 may be used as a simple non-expensive formula for the screening of HCC rather than MFAP4.

Potential role of pulses in the development of functional foods modulating inflammation and oxidative stress

2022 ◽  
pp. 287-309
Author(s):  
Helena Ferreira ◽  
Elisabete Pinto ◽  
Ana M. Gil ◽  
Marta W. Vasconcelos
Keyword(s):  
Oxidative Stress ◽  
Functional Foods ◽  
Potential Role ◽  
And Oxidative Stress

scholarly journals Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress

2018 ◽  
Vol 9 ◽  
Author(s):  
Maria Sole Chimenti ◽  
Flavia Sunzini ◽  
Laura Fiorucci ◽  
Elisabetta Botti ◽  
Giulia Lavinia Fonti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Psoriatic Arthritis ◽  
Cytochrome C ◽  
Potential Role ◽  
And Oxidative Stress

scholarly journals Urinary 1H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Maria Cristina Pintus ◽  
Milena Lussu ◽  
Angelica Dessì ◽  
Roberta Pintus ◽  
Antonio Noto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neonatal Intensive Care ◽  
Biological Fluids ◽  
Medical Knowledge ◽  
University Hospital ◽  
Control Group ◽  
Multivariate Statistical ◽  
H Nmr ◽  
And Oxidative Stress

Despite the advancements in medical knowledge and technology, the etiopathogenesis of bronchopulmonary dysplasia (BPD) is not yet fully understood although oxidative stress seems to play a role, leading to a very demanding management of these patients by the neonatologist. In this context, metabolomics can be useful in understanding, diagnosing, and treating this illness since it is one of the newest omics science that analyzes the metabolome of an individual through the investigation of biological fluids such as urine and blood. In this study, 18 patients admitted to the Neonatal Intensive Care Unit of the Cagliari University Hospital were enrolled. Among them, 11 patients represented the control group and 7 patients subsequently developed BPD. A sample of urine was collected from each patient at 7 days of life and analyzed through 1H-NMR coupled with multivariate statistical analysis. The discriminant metabolites between the 2 groups noted were alanine, betaine, trimethylamine-N-oxide, lactate, and glycine. Utilizing metabolomics, it was possible to detect the urinary metabolomics fingerprint of neonates in the first week of life who subsequently developed BPD. Future studies are needed to confirm these promising results suggesting a possible role of microbiota and oxidative stress, and to apply this technology in clinical practice.

scholarly journals Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elena C. Gross ◽  
Niveditha Putananickal ◽  
Anna-Lena Orsini ◽  
Deborah R. Vogt ◽  
Peter S. Sandor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Function ◽  
Lipid Peroxide ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Potential Biomarker ◽  
Plasma Antioxidant Capacity ◽  
And Oxidative Stress

AbstractIncreasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function/oxidative stress markers have not yet been examined. To this end, alpha-lipoic acid (ALA), total thiols, total plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c and lactate were determined in the serum of 32 higher frequency episodic migraineurs (5–14 migraine days/ months, 19 with aura, 28 females) in this cross-sectional study. The majority of patients had abnormally low ALA and lactate levels (87.5% and 78.1%, respectively). 46.9% of the patients had abnormally high PerOx values, while for thiols and TAC over one third of patients had abnormally low values (31.2% and 37.5%, respectively). 21.9% of patients had abnormally low HbA1c and none had an HbA1c level above 5.6%. oxLDL was normal in all but one patient. This study provides further evidence for a role of oxidative stress and altered metabolism in migraine pathophysiology, which might represent a suitable therapeutic target. ALA, being too low in almost 90% of patients, might represent a potential biomarker for migraine. Further research is needed to replicate these results, in particular a comparison with a control group.This study is part of the trial registration: ClinicalTrials.gov: NCT03132233, registered on 27.04.2017, https://clinicaltrials.gov/ct2/show/NCT03132233.

scholarly journals Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

2020 ◽  
Author(s):  
Elena C Gross ◽  
Niveditha Putananickal ◽  
Anna-Lena Orsini ◽  
Deborah R. Vogt ◽  
Peter S. Sandor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Function ◽  
Lipid Peroxide ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Potential Biomarker ◽  
Plasma Antioxidant Capacity ◽  
And Oxidative Stress

Abstract Introduction Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function / oxidative stress markers have not yet been examined. Methods To this end, alpha-lipoic acid (ALA), total thiols, total plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c and lactate were determined in the serum of 32 higher frequency episodic migraineurs (5-14 migraine days/ months, 19 with aura, 28 females) in this cross-sectional study. Results The majority of patients had abnormally low ALA and lactate levels (87.5% and 78.1%, respectively). 46.9% of the patients had abnormally high PerOx values, while for thiols and TAC over one third of patients had abnormally low values (31.2% and 37.5%, respectively). 21.9% of patients had abnormally low HbA1c and none had an HbA1c level above 5.6%. oxLDL was normal in all but one patient. Discussion This study provides further evidence for a role of oxidative stress and altered metabolism in migraine pathophysiology, which might represent a suitable therapeutic target. ALA, being too low in almost 90% of patients, might represent a potential biomarker for migraine. Further research is needed to replicate these results, in particular a comparison with a control group. This study is part of the trial registration: ClinicalTrials.gov: NCT03132233, registered on 27.04.2017, https://clinicaltrials.gov/ct2/show/NCT03132233

scholarly journals Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0163827 ◽  
Author(s):  
Sabina Ranjit ◽  
Narasimha M. Midde ◽  
Namita Sinha ◽  
Benjamin J. Patters ◽  
Mohammad A. Rahman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Potential Role ◽  
Cytochromes P450 ◽  
Monocytic Cells ◽  
And Oxidative Stress

scholarly journals Markers for Inflammation and Oxidative Stress in Patients with Coronary Artery Disease and Microvascular Disease – Is there a Difference?

2019 ◽  
Vol 46 (3) ◽  
pp. 34-36
Author(s):  
Z. Cherneva ◽  
R. Cherneva ◽  
E. Manov ◽  
N. Runev
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Microvascular Disease ◽  
Control Group ◽  
Atypical Chest Pain ◽  
Hs Crp ◽  
Artery Disease ◽  
And Oxidative Stress

Abstract Introduction: The clinical significance of inflammation (and markers such as resistin, hsCRP) and oxidative stress (e.g. 8-isoprostanes) for microvascular disease (MVD) and coronary artery disease (CAD) is still elusive. Aims: To determine the role of the markers for inflammation and oxidative stress as independent markers for MVD. Methods: Ninety consecutive patients were recruited: twenty-five of them had CAD; thirty – MVD and thirty-five were controls. The latter included patients with atypical chest pain, risk factors, lack of coronary artery disease and negative adenosine test. Coronary angiography was performed in all participants. The adenosine test was performed in those without CAD, hs CRP, resistin in plasma and urine 8-isoprostanes were measured. The correlation of all these indicators with CAD and MVD was analyzed. Results: The 8-isoprostanes showed significant differences between patients with MVD and CAD (0,055/0,52 pg/mmol Cre; p = 0,028). The same trend was found between CAD patients and the control group (0,055/0,003 pg/mmol Cre; p = 0,041); as well as between those with MVD and the control group (0,52/0,003 pg/mmol Cre; p = 0,001). The highest values of 8-isoprostanes were detected in patients with MVD – 0,52 pg/mmol Cre. Markers for inflammation were similar in patients with MVD and CAD (hsCRP- p = 0,091; resistin − p = 0,32). Conclusions: hs CRP, resistin and 8-isoprostanes are involved in the pathogenesis of both CAD and MVD. However, oxidative stress is probably more important for MVD, therefore 8-isoprostanes can be a part of panel of markers for its detection and analysis.

The potential role of Punica granatum treatment on murine malaria-induced hepatic injury and oxidative stress

2015 ◽  
Vol 115 (4) ◽  
pp. 1427-1433 ◽  
Author(s):  
Taghreed A. Hafiz ◽  
Murad A. Mubaraki ◽  
Saleh Al-Quraishy ◽  
Mohamed A. Dkhil
Keyword(s):  
Oxidative Stress ◽  
Hepatic Injury ◽  
Potential Role ◽  
Punica Granatum ◽  
And Oxidative Stress

scholarly journals Exploring Biologic Correlates of Cancer-Related Fatigue in Men With Prostate Cancer: Cell Damage Pathways and Oxidative Stress

2020 ◽  
Vol 22 (4) ◽  
pp. 514-519
Author(s):  
Kristin Dickinson ◽  
Adam J. Case ◽  
Kevin Kupzyk ◽  
Leorey Saligan
Keyword(s):  
Oxidative Stress ◽  
Prostate Cancer ◽  
Potential Role ◽  
Cell Damage ◽  
Cellular Responses ◽  
Preliminary Evidence ◽  
Cancer Related Fatigue ◽  
Targeted Treatments ◽  
And Oxidative Stress

The pathobiology of cancer-related fatigue (CRF) remains elusive, hindering the development of targeted treatments. Radiation therapy (RT), a common treatment for men with prostate cancer, induces cell damage through the generation of free radicals and oxidative stress. We hypothesized that disruption in cellular responses to this surge of nonphysiological oxidative stress might contribute to CRF in men with prostate cancer treated with RT. We evaluated the potential role of three cell damage pathways (apoptosis, autophagy, necrosis) and oxidative stress in CRF in men with prostate cancer receiving RT. Fatigue was measured by the Functional Assessment of Cancer Therapy-Fatigue (FACT-F) questionnaire. Gene expression was measured in whole blood using RT2 profiler™ PCR arrays. Data were collected at two time points: either baseline or Day 1 of treatment (T1) and completion of treatment (T2). Participants were grouped into either the fatigued or nonfatigued phenotype at T2 using the recommended FACT-F cut-off score for clinical significance. We observed significant upregulation of seven genes related to three cell damage pathways in the fatigued group from T1 to T2 and no significant changes in the nonfatigued group. We also observed significant downregulation of two genes related to oxidative stress in the fatigued group compared to the nonfatigued group at T2. These collective results provide preliminary evidence that cell damage might be upregulated in the CRF phenotype. Validation of these findings using a larger and more diverse sample is warranted.

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