scholarly journals Micro-Lensed Negative-Curvature Fibre Probe for Raman Spectroscopy

Sensors ◽  
2021 ◽  
Vol 21 (24) ◽  
pp. 8434
Author(s):  
Karolina Milenko ◽  
Stephanos Yerolatsitis ◽  
Astrid Aksnes ◽  
Dag Roar Hjelme ◽  
James M. Stone
Keyword(s):  
Raman Spectroscopy ◽  
Aqueous Solutions ◽  
Negative Curvature ◽  
Collection Efficiency ◽  
Fibre Probe

We developed a novel miniature micro-lensed fibre probe for Raman spectroscopy. The fibre probe consists of a single negative-curvature fibre (NCF) and a spliced, cleaved, micro-lensed fibre cap. Using a single NCF, we minimized the Raman background generated from the silica and maintained the diameter of the probe at less than 0.5 mm. In addition, the cap provided fibre closure by blocking the sample from entering the hollow parts of the fibre, enabling the use of the probe in in vivo applications. Moreover, the micro-lensed cap offered an improved collection efficiency (1.5-times increase) compared to a cleaved end-cap. The sensing capabilities of the micro-lensed probe were demonstrated by measuring different concentrations of glucose in aqueous solutions.

scholarly journals Applications of Vibrational Spectroscopy for Analysis of Connective Tissues

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 922
Author(s):  
William Querido ◽  
Shital Kandel ◽  
Nancy Pleshko
Keyword(s):  
Raman Spectroscopy ◽  
Vibrational Spectroscopy ◽  
Near Infrared ◽  
Ex Vivo ◽  
Biological Tissues ◽  
Label Free ◽  
Connective Tissues ◽  
Bone Properties ◽  
Composition And Structure

Advances in vibrational spectroscopy have propelled new insights into the molecular composition and structure of biological tissues. In this review, we discuss common modalities and techniques of vibrational spectroscopy, and present key examples to illustrate how they have been applied to enrich the assessment of connective tissues. In particular, we focus on applications of Fourier transform infrared (FTIR), near infrared (NIR) and Raman spectroscopy to assess cartilage and bone properties. We present strengths and limitations of each approach and discuss how the combination of spectrometers with microscopes (hyperspectral imaging) and fiber optic probes have greatly advanced their biomedical applications. We show how these modalities may be used to evaluate virtually any type of sample (ex vivo, in situ or in vivo) and how “spectral fingerprints” can be interpreted to quantify outcomes related to tissue composition and quality. We highlight the unparalleled advantage of vibrational spectroscopy as a label-free and often nondestructive approach to assess properties of the extracellular matrix (ECM) associated with normal, developing, aging, pathological and treated tissues. We believe this review will assist readers not only in better understanding applications of FTIR, NIR and Raman spectroscopy, but also in implementing these approaches for their own research projects.

In Vivo Bladder Cancer Diagnosis by High-Volume Raman Spectroscopy

2010 ◽  
Vol 82 (14) ◽  
pp. 5993-5999 ◽  
Author(s):  
Ronald O. P. Draga ◽  
Matthijs C. M. Grimbergen ◽  
Peter L. M. Vijverberg ◽  
Christiaan F. P. van Swol ◽  
Trudy G. N. Jonges ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bladder Cancer ◽  
Cancer Diagnosis ◽  
High Volume

scholarly journals Cooperative Raman Spectroscopy for Real-Time In Vivo Nano-Biosensing

2017 ◽  
Vol 16 (7) ◽  
pp. 571-584 ◽  
Author(s):  
Hongzhi Guo ◽  
Josep Miquel Jornet ◽  
Qiaoqiang Gan ◽  
Zhi Sun
Keyword(s):  
Raman Spectroscopy ◽  
Real Time

Non-invasive analysis of hormonal variations and effect of postmenopausal Vagifem treatment on women using in vivo high wavenumber confocal Raman spectroscopy

The Analyst ◽  
2013 ◽  
Vol 138 (14) ◽  
pp. 4120 ◽  
Author(s):  
Shiyamala Duraipandian ◽  
Wei Zheng ◽  
Joseph Ng ◽  
Jeffrey J. H. Low ◽  
A. Ilancheran ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

In vivo detection of cervical dysplasia with near-infrared Raman spectroscopy

2002 ◽  
Author(s):  
Amy Robichaux ◽  
Chad A. Lieber ◽  
Heidi Shappell ◽  
Beth Huff ◽  
Howard Jones III ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Near Infrared ◽  
Cervical Dysplasia

Multimodal endoscopic imaging and Raman spectroscopy for improving in vivo diagnosis of gastric malignancies during clinical gastroscopy

2010 ◽  
Author(s):  
Mads Sylvest Bergholt ◽  
Wei Zheng ◽  
Kan Lin ◽  
Khek Yu Ho ◽  
Khay Guan Yeoh ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Endoscopic Imaging ◽  
In Vivo Diagnosis

scholarly journals Real-time In vivo Diagnosis of Nasopharyngeal Carcinoma Using Rapid Fiber-Optic Raman Spectroscopy

Theranostics ◽  
2017 ◽  
Vol 7 (14) ◽  
pp. 3517-3526 ◽  
Author(s):  
Kan Lin ◽  
Wei Zheng ◽  
Chwee Ming Lim ◽  
Zhiwei Huang
Keyword(s):  
Raman Spectroscopy ◽  
Nasopharyngeal Carcinoma ◽  
Real Time ◽  
Fiber Optic ◽  
In Vivo Diagnosis

In vivo sensing of cutaneous edema: a comparative study of diffuse reflectance, Raman spectroscopy, and multispectral imaging

2021 ◽  
Author(s):  
Gleb S. Budylin ◽  
Denis A. Davydov ◽  
Nadezhda V. Zlobina ◽  
Alexey V. Baev ◽  
Vyacheslav G. Artyushenko ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Comparative Study ◽  
Diffuse Reflectance ◽  
Multispectral Imaging ◽  
In Vivo Sensing
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