scholarly journals Biomimetic Sensors to Detect Bioanalytes in Real-Life Samples Using Molecularly Imprinted Polymers: A Review

Sensors ◽  
2021 ◽  
Vol 21 (16) ◽  
pp. 5550 ◽  
Author(s):  
Birgit Bräuer ◽  
Christine Unger ◽  
Martin Werner ◽  
Peter A. Lieberzeit
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Large Body ◽  
Real Life ◽  
Biological Species ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Artificial Receptors ◽  
Main Emphasis ◽  
Research Stage ◽  
Transducer Type

Molecularly imprinted polymers (MIPs) come with the promise to be highly versatile, useful artificial receptors for sensing a wide variety of analytes. Despite a very large body of literature on imprinting, the number of papers addressing real-life biological samples and analytes is somewhat limited. Furthermore, the topic of MIP-based sensor design is still, rather, in the research stage and lacks wide-spread commercialization. This review summarizes recent advances of MIP-based sensors targeting biological species. It covers systems that are potentially interesting in medical applications/diagnostics, in detecting illicit substances, environmental analysis, and in the quality control of food. The main emphasis is placed on work that demonstrates application in real-life matrices, including those that are diluted in a reasonable manner. Hence, it does not restrict itself to the transducer type, but focusses on both materials and analytical tasks.

Application of molecularly imprinted polymers as artificial receptors for imaging

2020 ◽  
Vol 101 ◽  
pp. 444-458 ◽  
Author(s):  
Tereza Vaneckova ◽  
Jaroslava Bezdekova ◽  
Gang Han ◽  
Vojtech Adam ◽  
Marketa Vaculovicova
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Artificial Receptors

scholarly journals Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Sensors ◽  
2020 ◽  
Vol 20 (4) ◽  
pp. 996 ◽  
Author(s):  
Feiyun Cui ◽  
Zhiru Zhou ◽  
H. Susan Zhou
Keyword(s):  
Infectious Diseases ◽  
Molecularly Imprinted Polymers ◽  
Low Cost ◽  
Electrochemical Biosensors ◽  
Critical Element ◽  
Preparation Methods ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Artificial Receptors ◽  
Stability And Accuracy

Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.

scholarly journals Mass-Sensitive Sensing of Melamine in Dairy Products with Molecularly Imprinted Polymers: Matrix Challenges

Sensors ◽  
2019 ◽  
Vol 19 (10) ◽  
pp. 2366 ◽  
Author(s):  
Martin Zeilinger ◽  
Hermann Sussitz ◽  
Wim Cuypers ◽  
Christoph Jungmann ◽  
Peter Lieberzeit
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Real Life ◽  
Amino Acid Content ◽  
Sensor Response ◽  
Systematic Evaluation ◽  
Frequency Change ◽  
Serum Samples ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
High Amino Acid

Food standards and quality control are important means to ensure public health. In the last decade, melamine has become a rather notorious example of food adulteration: Spiking products with low-cost melamine in order to feign high amino acid content exploits the lack in specificity of the established Kjeldahl method for determining organic nitrogen. This work discusses the responses of a sensor based on quartz crystal microbalances (QCM) coated with molecularly imprinted polymers (MIP) to detect melamine in real life matrices both in a selective and a sensitive manner. Experiments in pure milk revealed no significant sensor responses. However, sensor response increased to a frequency change of −30Hz after diluting the matrix ten times. Systematic evaluation of this effect by experiments in melamine solutions containing bovine serum albumin (BSA) and casein revealed that proteins noticeably influence sensor results. The signal of melamine in water (1600 mg/L) decreases to half of its initial value, if either 1% BSA or casein are present. Higher protein concentrations decrease sensor responses even further. This suggests significant interaction between the analyte and proteins in general. Follow-up experiments revealed that centrifugation of tagged serum samples results in a significant loss of sensor response, thereby further confirming the suspected interaction between protein and melamine.

Sign in / Sign up

Export Citation Format

Share Document