scholarly journals A Review of the Use of Carbon Nanotubes and Graphene-Based Sensors for the Detection of Aflatoxin M1 Compounds in Milk

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3602
Author(s):  
Jingrong Gao ◽  
Shan He ◽  
Anindya Nag ◽  
Jonathan Woon Chung Wong

This paper presents a comprehensive review of the detection of aflatoxin compounds using carbon allotrope-based sensors. Although aflatoxin M1 and its derivative aflatoxin B1 compounds have been primarily found in milk and other food products, their presence above a threshold concentration causes disastrous health-related anomalies in human beings, such as growth impairment, underweight and even carcinogenic and immunosuppressive effects. Among the many sensors developed to detect the presence of these compounds, the employment of certain carbon allotropes, such as carbon nanotubes (CNTs) and graphene, has been highly preferred due to their enhanced electromechanical properties. These conductive nanomaterials have shown excellent quantitative performance in terms of sensitivity and selectivity for the chosen aflatoxin compounds. This paper elucidates some of the significant examples of the CNTs and graphene-based sensors measuring Aflatoxin M1 (ATM1) and Aflatoxin B1 (AFB1) compounds at low concentrations. The fabrication technique and performance of each of the sensors are shown here, as well as some of the challenges existing with the current sensors.

2020 ◽  
Author(s):  
Sicong Liu ◽  
Jonathan Folstein ◽  
Lawrence Gregory Appelbaum ◽  
Gershon Tenenbaum

Although the unwanted intrusive thoughts (UITs) exist widely in human beings and show similar characteristics between clinical and nonclinical forms, its control process remains unclear. Thoughts of choking under pressure, particularly among high-achieving athletes, represent a meaningful UIT type due to their psychological and performance-related impact. Taking a dynamic view of UIT control process, this study tested the effect of thought-control strategies among sub-elite to elite athletes, applied to individualized choking thoughts. Ninety athletes recollected recent athletic choking experiences prior to being randomized into one of three thought control interventions using strategies of either acceptance, passive monitoring (control), or suppression. To control for individual differences, athletes’ working memory capacity was measured and modeled as a covariate at baseline. The activation of choking thoughts during and after the intervention was gauged through multiple measurement approaches including conscious presence in mind, priming, and event-related potentials (P3b and N400 amplitudes). Results indicated that, relative to the control, suppression led to enhanced priming and reduced conscious presence of choking thoughts, whereas acceptance resulted in an opposite pattern of reduced priming and increased conscious presence of choking thoughts. In addition, thought-related stimuli elicited less negative-going N400 amplitudes and more positive-going P3b amplitudes than control stimuli. These findings advance understandings of the control mechanism underpinning UITs, and generate applied implications regarding UIT control in high-risk populations such as those with athletic expertise.


2020 ◽  
Vol 384 (2) ◽  
pp. 222-232
Author(s):  
P. V. Menshikov ◽  
G. K. Kassymova ◽  
R. R. Gasanova ◽  
Y. V. Zaichikov ◽  
V. A. Berezovskaya ◽  
...  

A special role in the development of a pianist as a musician, composer and performer, as shown by the examples of the well-known, included in the history of art, and the most ordinary pianists, their listeners and admirers, lovers of piano music and music in general, are played by moments associated with psychotherapeutic abilities and music features. The purpose of the study is to comprehend the psychotherapeutic aspects of performing activities (using pianists as an example). The research method is a theoretical analysis of the psychotherapeutic aspects of performing activities: the study of the possibilities and functions of musical psychotherapy in the life of a musician as a “(self) psychotherapist” and “patient”. For almost any person, music acts as a way of self-understanding and understanding of the world, a way of self-realization, rethinking and overcoming life's difficulties - internal and external "blockages" of development, a way of saturating life with universal meanings, including a person in the richness of his native culture and universal culture as a whole. Art and, above all, its metaphorical nature help to bring out and realize internal experiences, provide an opportunity to look at one’s own experiences, problems and injuries from another perspective, to see a different meaning in them. In essence, we are talking about art therapy, including the art of writing and performing music - musical psychotherapy. However, for a musician, music has a special meaning, special significance. Musician - produces music, and, therefore, is not only an “object”, but also the subject of musical psychotherapy. The musician’s training includes preparing him as an individual and as a professional to perform functions that can be called psychotherapeutic: in the works of the most famous performers, as well as in the work of ordinary teachers, psychotherapeutic moments sometimes become key. Piano music and performance practice sets a certain “viewing angle” of life, and, in the case of traumatic experiences, a new way of understanding a difficult, traumatic and continuing to excite a person event, changing his attitude towards him. It helps to see something that was hidden in the hustle and bustle of everyday life or in the patterns of relationships familiar to a given culture. At the same time, while playing music or learning to play music, a person teaches to see the hidden and understand the many secrets of the human soul, the relationships of people.


Aflatoxin M1 is one of mycotoxin derivatives, which is secreted in milk of dairy cattle fed on feed contaminated with Aflatoxin-B1 (AFB1). The current study was designed to prepare a vaccine against AFB1and to evaluate its efficacy in reducing or preventing secretion of AFM1 in milk. Aflatoxin-B1 was prepared, purified and transformed into oxime, then it was fixed on bovine serum albumins. The AFB1-BSA conjugate was adjuvanted with Gold Nano particles then Montanide ISA 206. The prepared vaccine was used for immunization of rabbits by S/c routes as 100 µg/dose and dairy cattle by I/M routes as 500 µg/dose. The vaccinated animals were boosted at 3 weeks post primary immunization. Serum samples were collected and examined for the anti-AFB1 using AGPT. A mean titer of 15.2 AGPU/ml was detected at 2 weeks post primary vaccination then significantly increased till reached to 76.8 AGPU/ml at 6 weeks post Booster vaccination. All vaccinated rabbits were challenged with dose of 0.3 mg AFB1 toxin/Kg. The vaccinated rabbit showed 100% protection and no AFB1 toxin residue was detected in their livers. Milk samples were collected from non-vaccinated and AFB1-immunized dairy cattle then examined with ELISA for quantitation of AFM1 residues before and after vaccination. The results showed that the prepared AFB1 vaccine was safe, potent and able to reduce AFM1 release in milk of vaccinated heifers by 70%. So the vaccination of lactating animals with the AFB1vaccine might represent a valid tool for the prevention of AFM1 contamination of milk and dairy products.


Magnanimity is a virtue that has led many lives. Foregrounded early on by Plato as the philosophical virtue par excellence, it became one of the crown jewels in Aristotle’s account of human excellence and was accorded an equally salient place by other ancient thinkers. One of the most distinctive elements of the ancient tradition to filter into the medieval Islamic and Christian worlds, it sparked important intellectual engagements there and went on to carve deep tracks through several later philosophies that inherited from this tradition. Under changing names, under reworked forms, it continued to breathe in the thought of Descartes and Hume, Kant and Nietzsche, and their successors. Its many lives have been joined by important continuities. Yet they have also been fragmented by discontinuities—discontinuities reflecting larger shifts in ethical perspectives and competing answers to questions about the nature of the good life, the moral nature of human beings, and their relationship to the social and natural world they inhabit. They have also been punctuated by moments of controversy in which the greatness of this vision of human greatness has itself been called into doubt. This volume provides a window to the complex trajectory of a virtue whose glitter has at times been as heady as it has been divisive. By exploring the many lives it has lived, we will be in a better position to decide whether and why this is a virtue we might still want to make central to our own ethical lives.


ChemInform ◽  
2015 ◽  
Vol 46 (37) ◽  
pp. no-no
Author(s):  
M. Melchionna ◽  
S. Marchesan ◽  
M. Prato ◽  
P. Fornasiero
Keyword(s):  

2021 ◽  
Vol 26 (4) ◽  
pp. 2759-2764
Author(s):  
DRAGAN GLAMOČIĆ ◽  
MIROSLAVA POLOVINSKI HORVATOVIĆ ◽  
IGOR JAJIĆ ◽  
SAŠA KRSTOVIĆ ◽  
MIRKO IVKOVIĆ ◽  
...  

Nutrition of dairy cattle is based on two components, concentrates and forages. The main forages in Vojvodina, north province of Serbia is silage made from the whole plant of corn. After the outbreak of aflatoxin B1 in corn in 2012, the occurrence of aflatoxin B1 in corn as a source of contamination of aflatoxin M1 in milk was very broadly investigated. There is no data regarding the occurrence of aflatoxin B1 in silage and how much silage can contribute to the overall intake of aflatoxin B1 in this region. This work is an attempt to estimate how much silage, in condition and practice used in Vojvodina, contributes to the intake of aflatoxin B1, and consequently aflatoxin M1 in milk. In total, 82 samples of corn grain and 72 samples of corn silage were analyzed on the occurrence of aflatoxin B1 during 2017-2018 period. Aflatoxin B1 was found in 13.41% of corn samples in the range from 6.82 to 187.5 ppb (average 63.5 ppb). All positive samples were from 2017, while no positive samples were found during 2018. Incidence of aflatoxin B1 in silage was 54.17% in the range of 3.5-58.0 ppb (12% moisture content) or 0.95-16.1 ppb in the fresh matter. Results suggest that silage can be a significant factor to overall intake of aflatoxin B1 and that further research is needed.


Membranes ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 106 ◽  
Author(s):  
Yehia M. Manawi ◽  
Kui Wang ◽  
Viktor Kochkodan ◽  
Daniel J. Johnson ◽  
Muataz A. Atieh ◽  
...  

In this work, novel polysulphone (PS) porous membranes for water desalination, incorporated with commercial and produced carbon nanotubes (CNT), were fabricated and analyzed. It was demonstrated that changing the main characteristics of CNT (e.g., loading in the dope solutions, aspect ratio, and functionality) significantly affected the membrane properties and performance including porosity, water flux, and mechanical and surface properties. The water flux of the fabricated membranes increased considerably (up to 20 times) along with the increase in CNT loading. Conversely, yield stress and Young’s modulus of the membranes dropped with the increase in the CNT loading mainly due to porosity increase. It was shown that the elongation at fracture for PS/0.25 wt. % CNT membrane was much higher than for pristine PS membrane due to enhanced compatibility of commercial CNTs with PS matrix. More pronounced effect on membrane’s mechanical properties was observed due to compatibility of CNTs with PS matrix when compared to other factors (i.e., changes in the CNT aspect ratio). The water contact angle for PS membranes incorporated with commercial CNT sharply decreased from 73° to 53° (membrane hydrophilization) for membranes with 0.1 and 1.0 wt. % of CNTs, while for the same loading of produced CNTs the water contact angles for the membrane samples increased from 66° to 72°. The obtained results show that complex interplay of various factors such as: loading of CNT in the dope solutions, aspect ratio, and functionality of CNT. These features can be used to engineer membranes with desired properties and performance.


2000 ◽  
Vol 27 ◽  
pp. 325-337 ◽  
Author(s):  
Jay Spaulding

Modern nationalisms first arose during the later eighteenth century around the wide periphery of the ancient heartland of western culture and gnawed their way inward during the course of the nineteenth century to the core, culminating in World War I, Each new nationalism generated an original “imagined community” of human beings, part of whose ideological cohesion derived from a sense of shared historical experience. Since the actual historical record would not necessarily satisfy this hunger, it was often found expedient to amend the past through acts of imagination aptly termed the “invention of tradition.”One of the many new “imagined communities” of the long nineteenth century took shape in the northern Nile-valley Sudan between the final disintegration of the old kingdom of Sinnar (irredeemable after the death of the strongman Muhammad Abu Likaylik in 1775) and the publication of Harold MacMichael's A History of the Arabs in the Sudan in 1922. The new national community born of the collapse of Sinnar, strongly committed to Arabic speech and Islamic faith, was tested by fire through foreign conquest and revolution, by profound socio-economic transformation, and by the challenges attendant on participation in an extended sub-imperialism that earned it hegemony—first cultural, and ultimately political—over all the diverse peoples of the modern Sudan.One important response of the nascent community to the trials of this difficult age was the invention of a new national historical tradition, according to which its members were descended via comparatively recent immigrants to the Sudan from eminent Arabs of Islamic antiquity.


2012 ◽  
Vol 6 (3) ◽  
pp. 767-774 ◽  
Author(s):  
Wenxiao Jiang ◽  
Zhanhui Wang ◽  
Greta Nölke ◽  
Jing Zhang ◽  
Lanlan Niu ◽  
...  

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